A-type Ce2NCl3

Cerium(III) nitride chloride, Ce2NCl3, contains trans-edge connected [NCe4]9+ tetra­hedra (222 symmetry) forming chains parallel to the c axis that are separated by Cl− anions. The Ce3+ cations (..m symmetry) are each surrounded by two N3− and six Cl− anions in a bicapped trigonal prismatic coordination geometry (CN = 8)

Processing counterfactual and hypothetical conditionals: An fMRI investigation

Counterfactual thinking is ubiquitous in everyday life and an important aspect of cognition and emotion. Although counterfactual thought has been argued to differ from processing factual or hypothetical information, imaging data which elucidate these differences on a neural level are still scarce. We investigated the neural correlates of processing counterfactual sentences under visual and aural presentation. We compared conditionals in subjunctive mood which explicitly contradicted previously presented facts (i.e. counterfactuals) to conditionals framed in indicative mood which did not contradict factual world knowledge and thus conveyed a hypothetical supposition. Our results show activation in right occipital cortex (cuneus) and right basal ganglia (caudate nucleus) during counterfactual sentence processing. Importantly the occipital activation is not only present under visual presentation but also with purely auditory stimulus presentation, precluding a visual processing artifact. Thus our results can be interpreted as reflecting the fact that counterfactual conditionals pragmatically imply the relevance of keeping in mind both factual and supposed information whereas the hypothetical conditionals imply that real world information is irrelevant for processing the conditional and can be omitted. The need to sustain representations of factual and suppositional events during counterfactual sentence processing requires increased mental imagery and integration efforts. Our findings are compatible with predictions based on mental model theory

Cs3Sm7Se12

The title compound, tricaesium hepta­samarium(III) dodeca­selenide, is setting a new starting point for realization of the channel structure of the Cs3 M 7Se12 series, now with M = Sm, Gd–Er. This Cs3Y7Se12-type arrangement is structurally based on the Z-type sesquiselenides M 2Se3 adopting the Sc2S3 structure. Thus, the structural set-up of Cs3Sm7Se12 consists of edge- and vertex-connected [SmSe6]9− octa­hedra [d Ø(Sm3+ – Se2−) = 2.931 Å], forming a rock-salt-related network [Sm7Se12]3− with channels along [001] that are apt to take up monovalent cations (here Cs+) with coordination numbers of 7 + 1 for one and of 6 for the second cation. The latter cation has a trigonal–prismatic coordination and shows half-occupancy, resulting in an impossible short distance [2.394 (4) Å] between symmetrically coupled Cs+ cations of the same kind. While one Sm atom occupies Wyckoff position 2b with site symmetry ..2/m, all other 11 crystallographically different atoms (namely 2 × Cs, 3 × Sm and 6 × Se) are located at Wyckoff positions 4g with site symmetry ..m

Impairment-based assessments for patients with lateral ankle sprain: A systematic review of measurement properties

Study design Systematic review. Background and objective The International Ankle Consortium developed a core outcome set for the assessment of impairments in patients with lateral ankle sprain (LAS) without consideration of measurement properties (MP). Therefore, the aim of this study is to investigate MPs of assessments for the evaluation of individuals with a history of LAS. Methods This systematic review of measurement properties follows PRISMA and COSMIN guidelines. Databases Pubmed, CINAHL, Embase, Web of Science, Cochrane Library and SPORTDiscus were searched for eligible studies (last search: July 2022). Studies on MP of specific tests and patient-reported outcome measurements (PROMs) in patients with acute and history of LAS (>4 weeks post injury) were deemed eligible. Results Ten studies of acute LAS and 39 studies of history of LAS patients with a total of 3313 participants met the inclusion criteria. Anterior Drawer Test (ADT) in supine position five days post injury and Reverse Anterolateral Drawer Test are recommended in acute settings in single studies. In the history of LAS patients, Cumberland Ankle Instability Tool (CAIT) (4 studies) as a PROM, Multiple Hop (3 studies) and Star Excursion Balance Tests (SEBT) (3 studies) for dynamic postural balance testing showed good MPs. No studies investigated pain, physical activity level and gait. Only single studies reported on swelling, range of motion, strength, arthrokinematics, and static postural balance. Limited data existed on responsiveness of the tests in both subgroups. Conclusion There was good evidence to support the use of CAIT as PROM, Multiple Hop, and SEBT for dynamic postural balance testing. Insufficient evidence exists in relation to test responsiveness, especially in the acute situation. Future research should assess MPs of assessments of other impairments associated with LAS

Ad Hoc Hypotheses and the Monsters within

Science is increasingly becoming automated. Tasks yet to be fully automated include the conjecturing, modifying, extending and testing of hypotheses. At present scientists have an array of methods to help them carry out those tasks. These range from the well-articulated, formal and unexceptional rules to the semi-articulated and variously understood rules-of-thumb and intuitive hunches. If we are to hand over at least some of the aforementioned tasks to machines, we need to clarify, refine and make formal, not to mention computable, even the more obscure of the methods scientists successfully employ in their inquiries. The focus of this essay is one such less-than-transparent methodological rule. I am here referring to the rule that ad hoc hypotheses ought to be spurned. This essay begins with a brief examination of some notable conceptions of ad hoc-ness in the philosophical literature. It is pointed out that there is a general problem afflicting most such conceptions, namely the intuitive judgments that are supposed to motivate them are not universally shared. Instead of getting bogged down in what ad hoc-ness exactly means, I shift the focus of the analysis to one undesirable feature often present in alleged cases of ad hoc-ness. I call this feature the ‘monstrousness’ of a hypothesis. A fully articulated formal account of this feature is presented by specifying what it is about the internal constitution of a hypothesis that makes it monstrous. Using this account, a monstrousness measure is then proposed and somewhat sketchily compared with the minimum description length approach

K2LaCl5

The ternary title compound, dipotassium lanthanum penta­chloride, K2LaCl5, is isotypic with Y2HfS5 and various ternary rare-earth metal(III) halides with the general formula A 2 MX 5 (A = NH4, InI, Na–Cs; M = La–Dy; X = Cl–I). The La3+ cations and three of the four symmetry-independent chloride anions are located on a crystallographic mirror plane. The La3+ cations are surrounded by seven chloride anions, each in the shape of a monocapped trigonal prism, whereas the coordination spheres of the K+ cations exhibit one more cap. Three of the four independent chloride anions reside in a fivefold cationic coordination, leading to distorted square pyramids. The fourth chloride anion has only four cationic neighbours, forming no specific polyhedron

Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines

An inverse relationship between protein kinase C (PKC) activity and oestrogen receptor (ER) expression in human breast cell lines and tumours has been firmly established over the past 10 years. To determine whether specific alterations in PKC expression accompany hormone-independence, we examined the expression of PKC isozymes in the hormone-independent human breast cancer cell clones MCF-7 5C and T47D:C42 compared with their hormone-dependent counterparts, MCF-7 A4, MCF-7 WS8 and T47D:A18 respectively. Both hormone-independent cell clones exhibit elevated PKCα expression and increased basal AP-1 activity compared with the hormone-dependent cell clones. To determine whether PKCα overexpression is sufficient to mediate the hormone-independent phenotype, we stably transfected an expression plasmid containing PKCα cDNA to the T47D:A18 and MCF-7 A4 cell lines. This is the first report of PKCα transfection in T47D cells. In contrast to MCF-7 cells, T47D has the propensity to lose the ER and more readily forms tamoxifen-stimulated tumours in athymic mice. We find that in T47D:A18/PKCα clones, there is concomitant up-regulation of PKC βI and δ, whereas in the MCF-7 A4/PKCα transfectants PKC ɛ is up-regulated. In T47D:A18, but not in MCF-7 A4, PKCα stable transfection is accompanied by down-regulation of ER function whilst basal AP-1 activity is elevated. Our results suggest PKCα overexpression may play a role in growth signalling during the shift from hormone dependent to hormone-independent breast cancers. © 2000 Cancer Research Campaig

Numerical schemes for continuum models of reaction-diffusion systems subject to internal noise

We present new numerical schemes to integrate stochastic partial differential equations which describe the spatio-temporal dynamics of reaction-diffusion (RD) problems under the effect of internal fluctuations. The schemes conserve the nonnegativity of the solutions and incorporate the Poissonian nature of internal fluctuations at small densities, their performance being limited by the level of approximation of density fluctuations at small scales. We apply the new schemes to two different aspects of the Reggeon model namely, the study of its non-equilibrium phase transition and the dynamics of fluctuating pulled fronts. In the latter case, our approach allows to reproduce quantitatively for the first time microscopic properties within the continuum model.Comment: 5 pages, 3 figures, Accepted for publication in Physical Review E as a Rapid Communicatio