Determine the Best and the Worst Solutions of Multi - Objective Linear Fractional Programming Problems with Interval Coefficients

فى هذا البحث درسنا مشاكل البرمجة الكسرية الخطية متعددة الاهداف بمعاملات ذات فترات . الهدف من هذا البحث هو لنبين العملية التكرارية الذى يتم استخدامه لحل هذه المشاكل. استنتاجات حول كيفية تصنيف (أفضل ،أسوأ) قيمة للاهداف، يتم تحويل المشكلات غير الخطية الى مشكلة برمجة خطية، مع وجود قيدين أو أكثر من نوع واحد بواسطة خوارزميتين(1) طرح الفاصل الزمني لبسط كسري من فاصل المقام و (2) المقام ليكون احد القيود، اخيرا بعد حل كل هدف دون فترات على حدة بطريقة السمبلكس المعدلة، نستخدم تقنية جديدة لتحويل مشاكل البرمجة الخطية متعددة الاهداف الى دالة احادية مع نفس القيود.تم توضيح بمثال عددي لإظهار كفاءة هذه الخوارزميات والتقنية الجديدة ثم مقارنة النتائج التي تم الحصول عليها للخوارزميتين بالجدول.                                                                                           In this paper, the Multi-objective linear fractional programming problems with interval coefficients (MOLFPPIC) is considered. The aim of this paper is to show an iterative procedure that can be utilized to solve such problems. Questions of how to select the (best, worst) value for the objective functions, the nonlinear problem is changed into a linear programming problem (LPP), with two or more constraints and more than one varieties by two algorithms (1) subtracting the interval of numerator of the fractional from the interval of denominator and (2) the denominator to be one of the constraints. Finally, after we solve each objective function without intervals individually by modified simplex method, we use a new technique via transforming it to single-objective function with the same constraints. Numerical examples are illustrated to show the efficiency of these algorithms and new technique

Diabetes mellitus and bell's palsy in Iranian population

During last decades many researchers have focused on the conditions associated with Bell's palsy including diabetes mellitus, hypertension, and viral infections. This study was performed to evaluate correlation of diabetes mellitus and Bell's palsy and some relevant features not discussed in the literature in an Iranian population. The presence of diabetes mellitus was evaluated in a total number of 275 subjects (75 patients with Bell's palsy and 200 control subjects). Diabetes mellitus was noted in 10 (13.3) patients with Bell's palsy among which 6 case were diagnosed as new cases of diabetes. Previous history of Bell's palsy was present in 10.67 of the subjects with Bell's palsy. This study confirms the correlation of diabetes mellitus and Bell's palsy for the first time in an Iranian population. We suggest screening tests for diabetes mellitus to be a routine part in the management of patients with Bell's palsy, especially in developing countries. © 2008 Tehran University of Medical Sciences. All rights reserved

The value of spreader grafts in rhinoplasty: a critical review

The value of spreader grafts in rhinoplasty cannot be underestimated. Various studies have demonstrated that they play a valuable role in the restoration of nasal dorsum aesthetics, provide support for the nasal valve and maintain the straightened position of the corrected deviated cartilaginous septal dorsum. However, there is still controversy on the extent of its value in nasal patency. This study reviews the literature and describes the values and limitations of spreader grafts in rhinoplasty and the alternatives to classic spreader grafts

Cervical lymphadenopathy as the only manifestation of Sarcoidosis

Sarcoidosis is a chronic multisystem disorder of unknown etiology. All parts of the body can be affected but the organ most frequently affected is the lung. Otolaryngologic manifestations occur in 20% to 40% of cases of Sarcoidosis and the spectrum of lesions that may come under the purview of Otolaryngologist is broad. In this case report a patient is presented with large cervical lymphadenopathy and without other manifestation of disorder

Folic acid supplementation

A 26-year-old woman is taking valproic acid for her stable Juvenile Myoclonic Epilepsy. There has been no other seizure medication which controlled her convulsive seizures except for valproic acid. She is taking prenatal vitamins since she is sexually active. Would you recommend higher dose of folic acid to her? How would you counsel her regarding the evidence for the dose you are recommending? Would it change your management if she was taking lamotrigine, topiramate, or levetiracetam

Comparison of GAS5 Long non-coding RNA Expression and NEAT1 in Breast Cancer Patients and Healthy People

Background & aim: Breast cancer entails 10% of all cancers in the world.  Among all types of cancers, 30 percent of women are infected with breast cancer. Non-coding of long RNA (lncRNA) is a new group of known genes in the human genome transcribed from large parts of the genome of eukaryotes and play an important role in the regulation of different biological processes. The aim of the present study was to compare the expression level of GAS5 lncRNA and NEAT1  in normal and neoplastic samples from breast cancer patients by RT-qPCR. Methods: In the present case-control study, 40 samples from patients with breast cancer tumor and 40 patients from non-tumor under the direct supervision of a pathologist specialist due to clinical presentation and laboratory findings were collected. After extracting DNA from normal and tumor tissues, cDNA synthesis method according to the protocol and RT-qPCR was performed by SYBR®Premix Ex TaqTM II kit.  LncRNA expression levels of genes GAS5 and NEAT1 was calculated using ΔΔCT. Data were analyzed using t-test. Results: The results of Real Time Reverse transcription-PCR indicated that partial expression levels of GAS5 lncRNA gene in tumor samples compared to normal GAS5 lncRNA of the gene, decreasing the expression, and the mean relative expression levels of lncRNA and NEAT1 gene in tumor samples compared to normal was overexpressed. These variation gene expression of LncRNA related to GAS5 about 1.5 times and 2 times to  lncRNA from  NEAT1 gene was observed respectively. Conclusion: Due to the previous reports, these lncRNAs act as tumor suppressor in breast cancer and had differential expression in tumor and normal tissues, which could be used as biomarker for cancer diagnosis. Moreover, expression of these lncRNAs in different breast cancer subtypes and patient with other blood raises the importance of this molecules as a biomarker for cancer diagnosis and prognosis