366 research outputs found
Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B
Background: HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials. We aimed to evaluate the predictive value of serum hyaluronate for the presence of extensive liver fibrosis and inflammation.
Methods: 28 healthy volunteers and 65 patients with HBeAg negative chronic hepatitis B were enrolled. Liver biopsies scored according to Ishak system. Association of serum hyaloronate with liver fibrosis and inflammation were assessed, and cut off points for serum hyaluronate levels were identified by receiver operating characteristics (ROC) curves and their values for prediction of fibrosis and inflammation were assessed.
Results: In patients with CHB serum hyaluronate had the most significant correlation and predictive values for the liver fibrosis and inflammation comparing to the other variables. At the cut off point of 126.4 ngm/ml it could discriminate extensive fibrosis from milder ones with sensitivity of 90.9% and specificity of 98.1%. With the same value it could discriminate extensive inflammation from their milder counterparts with sensitivity of 63.6% and specificity of 92.6%.
Conclusion: Serum hyaluronate was the best predictor of extensive liver fibrosis and inflammation and it could discriminate subgroups of patients with chronic hepatitis B. It could be used as a non-invasive test to monitor these patients more closely with developing anti viral agents in clinical trials
Reproductive biology of Indian squid, Uroteuthis duvauceli (Orbigny, 1835), in the northern Gulf of Oman
Some aspects of the reproductive biology of the Indian squid, Uroteuthis duvauceli, were studied from June 2006 to May 2007. A total of 1200 specimens were collected from approximately 30-80m depths by trawling in 50 stations, of which 360 samples were studied for sex determination and fecundity. The minimum and maximum total and mantle length, and body weight were recorded in December and June, respectively. The highest range of total length (410-420mm), mantle length (150-160mm) and body weight (90-100g) were encountered in September. The specimens were composed of 34% male and 66% female (M:F=1:2). This species was found to be more abundant in summer. The minimum and maximum ovary weights were 2.1g and 7.9g with an average of 4.9g, respectively. These values for nidamental gland weight were 0.70 and 2.61g with an average of 1.6g. The minimum and maximum absolute fecundity were 25510 (in August) and 375600 (in April), respectively. These values for relative fecundity were 5207 (in April) and 867 (in August), respectively. The highest gonadosomatic index (GSI) was in April (14.38) and the lowest was in July (8.63). This squid is, therefore, assumed to be a spring spawner. Minimum and maximum egg diameter were 0.72mm (in August) and 2.5mm (in April), respectively
Developing of Ethylene Glycol as a New Reducing Agent for Preparation of Pd-Ag/PSS Composite Membrane for Hydrogen Separation
In the present work, for the first time, a palladium-silver membrane has been prepared by electroless plating on the surface of a porous stainless steel disk by using ethylene glycol as a new reducing agent and polyol process. The reducing action of ethylene-glycol in the presence of PVP as a protecting surface agent produces a membrane with finely divided powder and nano-sized pores. Furthermore, the hydrogen separation ability of the membrane confirmed that the membrane with Pd77Ag23 is highly selective towards hydrogen compared to other prepared membranes. This is mainly related to the formation of dense and homogenous microstructure of the coating. Moreover, according to Grahamβs law, the tests showed that hydrogen purity rises by increasing the applying temperature
Kinematic 3D Retro-Deformation of Fault Blocks Picked from 3D Seismics
Movement on fault planes causes a large
amount of smaller-scale deformation,
ductile or brittle, in the area surrounding
the fault. Much of this deformation
is below the resolution of reflection
seismics (i.e. sub-seismic, <10m
displacement), but it is important to determine
this deformation, since it can
make up a large portion of the total bulk strain, for instance in a developing
sedimentary basin. Calculation of
the amount of sub-seismic strain around
a fault by 3-D geometrical kinematic
retro-deformation can also be used to
predict the orientation and magnitude
of these smaller-scale structures.
However, firstly a 3-D model of the fault
and its faulted horizons must be constructed
at a high enough resolution
to be able to preserve fault and horizon
morphology with a grid spacing of
less than 10 m. Secondly, the kinematics
of the fault need to be determined,
and thirdly a suitable deformation algorithm
chosen to fit the deformation
style. Then by restoring the faulted
horizons to their pre-deformation state
(a βregionalβ), the moved horizons can
be interrogated as to the strain they
underwent. Since strain is commutative,
the deformation demonstrated during
this retro-deformation is equivalent
to that during the natural, forward deformation...conferenc
The Study of Abnormal Liver Ultrasound Findings in Candidate Patients Undergoing Renal Transplantation from Brain Dead Donors
BACKGROUND AND OBJECTIVE: Chronic kidney disease in addition to kidney involvement may cause abnormalities in various systems of the body, in which liver disorders are one of the most commonly encountered disorders. Failure to identify some of these disorders can cause a serious problem in transolant patient. This study was performed to determine the frequency and type of abnormal liver ultrasound findings in renal transplant patients.
METHODS: In this cross-sectional study, recorded data of 480 kidney failure patients who had received kidney transplant from brain death donors during the last 6 years in three Mashhad hospitals were investigated. Ultrasonography was considered before the transplant and abnormal liver findings were recorded in a checklist and were assesed.
FINDINGS: The mean age was 39.07Β±12.67 years of which 52.70% were male and 42.30% were female. Liver disorders were observed in 13.12% of patients. The highest prevalence was related to fatty liver grade I (2.5%), grade II (1.46%), gallstone (1.25%) and liver cysts (1.25%).
CONCLUSION: The results of the study showed that liver asymptomatic disorders in renal transplant patients have significant prevalence and because some of these disorders require treatment before transplantation, enough attention to screening before transplantation can help to prevent post-transplant complications
Comparison the Effect of Placenta Membrane Using Alone or With Silver Sulfadiazine in Treatment of Burns in Rats
Aims: Silver sulfadiazine is widely used for burning wound. Studies have shown that, dressing wounds with placental membrane can accelerate their healing. Our objective was to evaluate the recovery of second-degree burns in male rats that treated with topical Silver sulfadiazine-impregnated placental amniotic membrane.
Materials & Methods: In this experimental study, 64 male rats were divided into 4 similar groups. In all rats, the second degree burn was induced under general anesthesia. Wound dressing in the first group (control) included simple dressing, but amniotic membrane in second group, and Silver sulfadiazine in third group and in the fourth group it was Silver sulfadiazine impregnated amniotic membrane. At the end of the 7th, 14th, 21st and 28th day, under the general anesthesia, the tissue biopsies were taken from burns and microscopic evaluation was done. Data were analyzed statistically using ANOVA and P less than 0.05 was considered as significant.
Findings: In treated groups, the PMN leukocyte count was significantly lower than control (p<0.001), also the amount of granular formation and its organization, the number of fibroblasts, and the rate of wound healing were greater than control (p<0.001). There was no significant difference in measured parameters between the 3 treatment groups.
Conclusion: Considering the biological effects of the ammonium membrane, it is recommended to use it as an effective dressing method to accelerate burn wound healing
ΠΠΎΡΠΈΠ²Π°ΡΠΈΡ ΡΠ΅Π»Π΅Π²ΡΡ Π³ΡΡΠΏΠΏ ΠΏΡΠΈ Π²ΡΠ²ΠΎΠ΄Π΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π½Π° ΡΡΠ½ΠΎΠΊ
Π‘Π΄Π΅Π»Π°Π½ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΠΏΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΠΈ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΡ ΠΊΠ»ΠΈΠ΅Π½ΡΠΎΠ² ΠΈ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»Π° ΠΏΠΎ Π³ΡΡΠΏΠΏΠ°ΠΌ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ
ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠ΅ΠΉ, ΠΊΠ°ΠΊ ΡΡΠΎ Π΄Π΅Π»Π°Π΅ΡΡΡ Ρ ΡΡΠ½ΠΊΠ°ΠΌΠΈ Π² ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³Π΅. Π ΡΠ°ΠΊΠΆΠ΅ Π²ΡΠ΄Π΅Π»Π΅Π½Ρ ΡΠ΅Π»Π΅Π²ΡΠ΅ Π³ΡΡΠΏΠΏΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° ΠΏΡΠΎΡΠ΅ΡΡ Π²ΡΠ²ΠΎΠ΄Π° Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠΎΠ΄ΡΠΊΡΠ° Π½Π° ΡΡΠ½ΠΎΠΊ, ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΡ
ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΠΈ
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