4,753 research outputs found
Lighting as a Circadian Rhythm-Entraining and Alertness-Enhancing Stimulus in the Submarine Environment
The human brain can only accommodate a circadian rhythm that closely follows 24 hours. Thus, for a work schedule to meet the brainâs hard-wired requirement, it must employ a 24 hour-based program. However, the 6 hours on, 12 hours off (6/12) submarine watchstanding schedule creates an 18-hour âdayâ that Submariners must follow. Clearly, the 6/12 schedule categorically fails to meet the brainâs operational design, and no schedule other than one tuned to the brainâs 24 hour rhythm can optimize performance. Providing Submariners with a 24 hour-based watchstanding scheduleâcombined with effective circadian entrainment techniques using carefully-timed exposure to lightâwould allow crewmembers to work at the peak of their daily performance cycle and acquire more restorative sleep. In the submarine environment, where access to natural light is absent, electric lighting can play an important role in actively entrainingâand closely maintainingâcircadian regulation. Another area that is likely to have particular importance in the submarine environment is the potential effect of light to help restore or maintain alertness
Magnetars' Giant Flares: the case of SGR 1806-20
We first review on the peculiar characteristics of the bursting and flaring
activity of the Soft Gamma-ray Repeaters and Anomalous X-ray Pulsars. We then
report on the properties of the SGR 1806-20's Giant Flare occurred on 2004
December 27th, with particular interest on the pre and post flare
intensity/hardness correlated variability. We show that these findings are
consistent with the picture of a twisted internal magnetic field which stresses
the star solid crust that finally cracks causing the giant flare (and the
observed torsional oscillations). This crustal fracturing is accompanied by a
simplification of the external magnetic field with a (partial) untwisting of
the magnetosphere.Comment: 6 pages, 2 figures; accepted for publication in the Chinese Journal
for Astronomy and Astrophysics (Vulcano conference - 2005
Peculiar Spin Frequency and Radio Profile Evolution of PSR J11196127 Following Magnetar-like X-ray Bursts
We present the spin frequency and profile evolution of the radio pulsar
J11196127 following magnetar-like X-ray bursts from the system in 2016 July.
Using data from the Parkes radio telescope, we observe a smooth and fast
spin-down process subsequent to the X-ray bursts resulting in a net change in
the pulsar rotational frequency of \,Hz.
During the transition, a net spin-down rate increase of
\,Hz\,s is observed, followed by a
return of to its original value. In addition, the radio pulsations
disappeared after the X-ray bursts and reappeared about two weeks later with
the flux density at 1.4\,GHz increased by a factor of five. The flux density
then decreased and undershot the normal flux density followed by a slow
recovery back to normal. The pulsar's integrated profile underwent dramatic and
short-term changes in total intensity, polarization and position angle. Despite
the complex evolution, we observe correlations between the spin-down rate,
pulse profile shape and radio flux density. Strong single pulses have been
detected after the X-ray bursts with their energy distributions evolving with
time. The peculiar but smooth spin frequency evolution of PSR~J11196127
accompanied by systematic pulse profile and flux density changes are most
likely to be a result of either reconfiguration of the surface magnetic fields
or particle winds triggered by the X-ray bursts. The recovery of spin-down rate
and pulse profile to normal provides us the best case to study the connection
between high magnetic-field pulsars and magnetars.Comment: Accepted for publication in MNRAS on 2018 July 2
"Hiccup" accretion in the swinging pulsar IGR J18245-2452
IGR J18245-2452 is the fifteenth discovered accreting millisecond X-ray
pulsar and the first source of this class showing direct evidence for
transition between accretion and rotational powered emission states. These
swing provided the strongest confirmation of the pulsar recycling scenario
available so far. During the two XMM-Newton observations that were carried out
while the source was in outburst in April 2013, IGR J18245-2452 displayed a
unique and peculiar variability of its X-ray emission. In this work, we report
on a detailed analysis of the XMM- Newton data and focus in particular on the
timing and spectral variability of the source. IGR J18245-2452 continuously
switches between lower and higher intensity states, with typical variations in
flux up to a factor of about 500 in time scales as short as few seconds. These
variations in the source intensity are sometimes associated to a dramatic
spectral hardening, during which the power-law photon index of the source
changes from Gamma=1.7 to Gamma=0.9. The pulse profiles extracted at different
count rates and energies show a complex variability. These phenomena are not
usually observed in accreting millisecond X-ray pulsars, at least not on such a
short time scale. Fast variability was also found in the ATCA radio
observations carried out for about 6 hours during the outburst at a frequency
of 5.5 and 9 GHz. We interpret the variability observed from IGR J18245-2452 in
terms of a "hiccup" accretion phase, during which the accretion of material
from the inner boundary of the Keplerian disk is reduced by the onset of
centrifugal inhibition of accretion, possibly causing the launch of strong
outflows. Changes across accretion and propeller regimes have been long
predicted and reproduced by MHD simulations of accreting millisecond X-ray
pulsars but never observed to produce an extreme variability as that shown by
IGR J18245-2452.Comment: A&A in press. Revised versio
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Teaching schools evaluation. Research Brief
This Research Brief reports the findings from a two-year study (2013-15) in to the work of teaching schools and their alliances commissioned by the National College for Teaching and Leadership (NCTL). The broad aim of the study was to investigate the effectiveness and impact of teaching schools on improvement, and identify the quality and scope of external support that are required to enhance these . This was achieved through combining qualitative and quantitative data collection and analysis derived from three research activities: case studies of 26 teaching schools alliances (TSAs), a national survey of the first three cohorts of 345 TSAs, and secondary research and analysis of national performance and inspection results
Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility. The most powerful AGE precursor is methylglyoxal (MG), a byproduct of glycolysis, that is detoxified by the glyoxalase system. By using a PCOS mouse model induced by administration of dehydroepiandrosterone (DHEA), we investigated whether MG-dependent glycative stress contributes to ovarian PCOS phenotype and explored changes in the Sirtuin 1 (SIRT1) functional network regulating mitochondrial functions and cell survival. In addition to anovulation and reduced oocyte quality, DHEA ovaries revealed altered collagen deposition, increased vascularization, lipid droplets accumulation and altered steroidogenesis. Here we observed increased intraovarian MG-AGE levels in association with enhanced expression of receptor for AGEs (RAGEs) and deregulation of the glyoxalase system, hallmarks of glycative stress. Moreover, DHEA mice exhibited enhanced ovarian expression of SIRT1 along with increased protein levels of SIRT3 and superoxide dismutase 2 (SOD2), and decreased peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1 alpha), mitochondrial transcriptional factor A (mtTFA) and translocase of outer mitochondrial membrane 20 (TOMM20). Finally, the presence of autophagy protein markers and increased AMP-activated protein kinase (AMPK) suggested the involvement of SIRT1/AMPK axis in autophagy activation. Overall, present findings demonstrate that MG-dependent glycative stress is involved in ovarian dysfunctions associated to PCOS and support the hypothesis of a SIRT1-dependent adaptive response
Small-area deprivation index does not improve the capability of multisource comorbidity score in mortality prediction
BackgroundThe stratification of the general population according to health needs allows to provide better-tailored services. A simple score called Multisource Comorbidity Score (MCS) has been developed and validated for predicting several outcomes. The aim of this study was to evaluate whether the ability of MCS in predicting 1-year mortality improves by incorporating socioeconomic data (as measured by a deprivation index). MethodsBeneficiaries of the Italian National Health Service who in the index year (2018) were aged 50-85 years and were resident in the Sicily region for at least 2 years were identified. For each individual, the MCS was calculated according to his/her clinical profile, and the deprivation index of the census unit level of the individual's residence was collected. Frailty models were fitted to assess the relationship between the indexes (MCS and deprivation index) and 1-year mortality. Akaike information criterion and Bayesian information criterion statistics were used to compare the goodness of fit of the model that included only MCS and the model that also contained the deprivation index. The models were further compared by means of the area under the receiver operating characteristic curve (AUC). ResultsThe final cohort included 1,062,221 individuals, with a mortality rate of 15.6 deaths per 1,000 person-years. Both MCS and deprivation index were positively associated with mortality.The goodness of fit statistics of the two models were very similar. For MCS only and MCS plus deprivation index models, Akaike information criterion were 17,013 and 17,038, respectively, whereas Bayesian information criterion were 16,997 and 17,000, respectively. The AUC values were 0.78 for both models. ConclusionThe present study shows that socioeconomic features as measured by the deprivation index did not improve the capability of MCS in predicting 1-year risk of death. Future studies are needed to investigate other sources of data to enhance the risk stratification of populations
Our distorted view of magnetars: application of the Resonant Cyclotron Scattering model
The X-ray spectra of the magnetar candidates are customarily fitted with an
empirical, two component model: an absorbed blackbody and a power-law. However,
the physical interpretation of these two spectral components is rarely
discussed. It has been recently proposed that the presence of a hot plasma in
the magnetosphere of highly magnetized neutron stars might distort, through
efficient resonant cyclotron scattering, the thermal emission from the neutron
star surface, resulting in the production of non-thermal spectra. Here we
discuss the Resonant Cyclotron Scattering (RCS) model, and present its XSPEC
implementation, as well as preliminary results of its application to Anomalous
X-ray Pulsars and Soft Gamma-ray Repeaters.Comment: 5 pages, 5 color figures; Astrophysics & Space Science, in press
("Isolated Neutron Stars"; London, UK
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