GRBs from unstable Poynting dominated outflows

Poynting flux driven outflows from magnetized rotators are a plausible explanation for gamma-ray burst engines. We suggest a new possibility for how such outflows might transfer energy into radiating particles. We argue that the Poynting flux drives non-linearly unstable large amplitude electromagnetic waves (LAEMW) which ``break'' at radii $r_t \sim 10^{14}$ cm where the MHD approximation becomes inapplicable. In the ``foaming'' (relativisticly reconnecting) regions formed during the wave breaks the random electric fields stochastically accelerate particles to ultrarelativistic energies which then radiate in turbulent electromagnetic fields. The typical energy of the emitted photons is a fraction of the fundamental Compton energy $\epsilon \sim f \hbar c/r_e$ with $f \sim 10^{-3}$ plus additional boosting due to the bulk motion of the medium. The emission properties are similar to synchrotron radiation, with a typical cooling time $\sim 10^{-4}$ sec. During the wave break, the plasma is also bulk accelerated in the outward radial direction and at larger radii can produce afterglows due to the interactions with external medium. The near equipartition fields required by afterglow models maybe due to magnetic field regeneration in the outflowing plasma (similarly to the field generation by LAEMW of laser-plasma interactions) and mixing with the upstream plasma.Comment: 15 pages, 1 figur

Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer

Generation of myeloid and lymphoid cells from progenitors involves dynamic changes in transcription factor expression and use, and disruption of hematopoietic transcription factor function and expression can contribute to leukemic transformation. PU.1 and Ikaros are pivotal factors whose expression and utilization are dynamically altered during hematopoietic development. Here, we demonstrate that expression of PU.1, encoded by the Sfpi1 gene, is divergently regulated by Ikaros in distinct cell type-specific contexts. Chromatin immune precipitation analysis and functional perturbations revealed that Ikaros can directly repress or activate Sfpi1 transcription via different PU.1 cis-elements, with PU.1 and Ikaros collaborating at myeloid-specific elements but not at other elements. Our results thus shed light on how PU.1 and Ikaros can act as lineage competency factors to facilitate both myeloid and lymphoid developmental programs

Asymmetric glottal jet deflection: differences of two- and three-dimensional models

Flow is studied through a channel with an oscillating orifice mimicking the motion of the glottal-gap during phonation. Simulations with prescribed flow and wall-motion are carried out for different orifice geometries, a 2D slit-like and a 3D lens-like one. Although the jet emerges from a symmetric orifice a significant deflection occurs in case of the slit-like geometry, contrary to the 3D lens-like one. The results demonstrate the dependency of jet entrainment and vortex dynamics on the orifice geometry and the interpretation of asymmetric jet deflection with regard to the relevance of the Coanda effect in the process of human phonation

Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

AbstractThe establishment of relative size of organs and structures is paramount for attaining final form and function of an organism. Importantly, variation in the proportions of structures frequently underlies adaptive change in morphology in evolution and maybe a common mechanism underlying selection. However, the mechanism by which growth is integrated within tissues during development to achieve proper proportionality is poorly understood. We have shown that signaling by potassium channels mediates coordinated size regulation in zebrafish fins. Recently, calcineurin inhibitors were shown to elicit changes in zebrafish fin allometry as well. Here, we identify the potassium channelkcnk5bas a key player in integrating calcineurin’s growth effects, in part through regulation of the cytoplasmic C-terminus of the channel. We propose that the interaction between Kcnk5b and calcineurin acts as a signaling node to regulate allometric growth. Importantly, we find that this regulation is epistatic to inherent mechanisms instructing overall size as inhibition of calcineurin is able to bypass genetic instruction of size as seen insofand wild-type fins, however, it is not sufficient to re-specify positional memory of size of the fin. These findings integrate classic signaling mediators such as calcineurin with ion channel function in the regulation of size and proportion during growth.</jats:p

Modeling Trajectories of Adolescent-Perceived Family Conflict: Effects of Marital Dissatisfaction and Parental Alcoholism

We evaluated the effects of marital dissatisfaction on adolescent-perceived conflict in 435 families with and without a parental history of alcoholism. On average, family conflict decreased linearly as adolescents aged. Families with an alcoholic parent demonstrated higher adolescent-reported family conflict and this effect was partially mediated by higher mother- and father-reported marital dissatisfaction. Families with higher marital dissatisfaction had greater conflict when adolescents were young (based on fathers' marital dissatisfaction) and as they aged (based on mother's marital dissatisfaction). Years in which mothers reported higher marital dissatisfaction than usual coincided with years in which adolescents reported greater family conflict. Results indicate that marital dissatisfaction has both within and between-family effects on adolescent perceptions of conflict

Preliminary Investigation of Performance and Starting Characteristics of Liquid Fluorine : Liquid Oxygen Mixtures with Jet Fuel

The performance of jet fuel with an oxidant mixture containing 70 percent liquid fluorine and 30 percent liquid oxygen by weight was investigated in a 500-pound-thrust engine operating at a chamber pressure of 300 pounds per square inch absolute. A one-oxidant-on-one-fuel skewed-hole impinging-jet injector was evaluated in a chamber of characteristic length equal to 50 inches. A maximum experimental specific impulse of 268 pound-seconds per pound was obtained at 25 percent fuel, which corresponds to 96 percent of the maximum theoretical specific impulse based on frozen composition expansion. The maximum characteristic velocity obtained was 6050 feet per second at 23 percent fuel, or 94 percent of the theoretical maximum. The average thrust coefficient was 1.38 for the 500-pound thrust combustion-chamber nozzle used, which was 99 percent of the theoretical (frozen) maximum. Mixtures of fluorine and oxygen were found to be self-igniting with jet fuel with fluorine concentrations as low as 4 percent, when low starting propellant flow rated were used

Intergenerational continuity in high-conflict family environments

Abstract In the current study, we examined continuity in conflict across generations and explored potential mediators and moderators that could explain this continuity. We followed 246 targets from adolescence to adulthood and examined family conflict as reported by multiple reporters in targets' family of origin and current families. Results showed that conflict in the current family was strongly correlated with that of the family of origin in women but not in men. Continuity in family conflict across generations was mediated by patterns of elevated adolescent externalizing behavior in members of the second generation (G2). In addition, analyses revealed an interaction between both G2 partners' externalizing behavior such that if one partner in the G2 family demonstrated high levels of externalizing behavior, elevated levels of family conflict resulted. Potential explanations and implications of these findings are considered

Buprenorphine added on brief cognitive behavioral therapy for treatment of methamphetamine use disorder

Background: Methamphetamine (MA) use remains a major public health concern around the world. Recent findings suggest that buprenorphine may be helpful for cocaine use reduction. Moreover, animal studies described reduced dopamine peak effect following MA use, due to the administration of low dose buprenorphine. Objectives: This study examined the effectiveness of buprenorphine with brief cognitive behavioral therapy on MA use disorder. Methods: The study was conducted in an outpatient substance abuse treatment center in Qazvin, Iran. Nineteen MA users received buprenorphine for 24 weeks combined with brief cognitive behavioral therapy in an outpatient substance abuse treatment program, three times per week, as a before and after non - randomization study. Clinical outcomes included treatment retention, MA use, degree of MA dependency and craving, quality of life, cognitive abilities questionnaire, addiction severity and also adverse events. Data was analyzed by performing repeated measures analysis and the Friedman test for nonparametric variables. Results: Fifteen participants completed the study during six months and frequency of MA use was significantly decreased at 24 weeks (P &lt; 0.001). There were also significant reductions in craving (P &lt; 0.001), degree of MA dependence (P &lt; 0.001), and improvements in quality of life, cognitive ability, and some subscales of addiction severity. Conclusions: The results of this preliminary clinical study demonstrated that buprenorphine could potentially attenuate MA craving and alternate rewarding effects of MA and had promising effects on cognitive impairment. Furthermore, buprenorphine can be considered as a harm reduction intervention in some communities, in which the people, as a result of cultural beliefs, do not accept a therapy, which only consists of counseling and no medications