Evaluation of the anisotropic mechanical properties of reinforced polyurethane foams

The mechanical impact of adding milled glass fibers and nanoparticles at different mass fractions to low-density (relative density < 0.2) polyurethane (PU) foams is investigated. Tensile, compressive, and shear stress–strain curves are measured in the plane parallel to the foam-rise direction and the in-plane components of the elastic modulus are determined in order to assess the mechanical anisotropy of the foams. Power-law relationships between the moduli and apparent density are established for pure PU foams and used as a baseline to which the properties of composite foams are compared. Cellular mechanics models based on both rectangular and Kelvin unit-cell geometries are employed to estimate changes in the cell shape based on the mechanical anisotropy of composite foams, and the model results are compared with direct observations of the cellular structure from microscopy. A single measure of foam stiffness reinforcement is defined that excludes the effects of the apparent foam density and cell shape. The analysis reveals the large impact of cell shape on the moduli of the glass-fiber and nanocomposite foams. Nanocomposite foams exhibit up to an 11.1% degree of reinforcement, and glass-fiber foams up to 18.7% using this method for quantifying foam reinforcement, whereas a simple normalization to the in-plane modulus components of the pure PU foam would indicate from ?40.5% to 25.9% reinforcement in nanocomposite foams, and ?7.5 to 20.2% in glass-fiber foams

Clinical and arrhythmic outcomes after implantation of a defibrillator for primary prevention of sudden death in patients with post-myocardial infarction cardiomyopathy: The Survey to Evaluate Arrhythmia Rate in High-risk MI patients (SEARCH-MI)

To evaluate clinical and arrhythmic outcomes in post-infarction cardiomyopathy patients implanted with a defibrillator (ICD) for primary prevention of sudden death

Lipidomics, atrial conduction, and body mass index: evidence from association, mediation, and Mendelian randomization models

BACKGROUND: Lipids are increasingly involved in cardiovascular risk prediction as potential proarrhythmic influencers. However, knowledge is limited about the specific mechanisms connecting lipid alterations with atrial conduction. METHODS: To shed light on this issue, we conducted a broad assessment of 151 sphingo- and phospholipids, measured using mass spectrometry, for association with atrial conduction, measured by P wave duration (PWD) from standard electrocardiograms, in the MICROS study (Microisolates in South Tyrol) (n=839). Causal pathways involving lipidomics, body mass index (BMI), and PWD were assessed using 2-sample Mendelian randomization analyses based on published genome-wide association studies of lipidomics (n=4034) and BMI (n=734 481), and genetic association analysis of PWD in 5 population-based studies (n=24 236). RESULTS: We identified an association with relative phosphatidylcholine 38:3 (%PC 38:3) concentration, which was replicated in the ORCADES (Orkney Complex Disease Study; n=951), with a pooled association across studies of 2.59 (95% CI, 1.3-3.9; P=1.1×10-4) ms PWD per mol% increase. While being independent of cholesterol, triglycerides, and glucose levels, the %PC 38:3-PWD association was mediated by BMI. Results supported a causal effect of BMI on both PWD ( P=8.3×10-5) and %PC 38:3 ( P=0.014). CONCLUSIONS: Increased %PC 38:3 levels are consistently associated with longer PWD, partly because of the confounding effect of BMI. The causal effect of BMI on PWD reinforces evidence of BMI's involvement into atrial electrical activity

A New Horned Crocodile from the Plio-Pleistocene Hominid Sites at Olduvai Gorge, Tanzania

BACKGROUND: The fossil record reveals surprising crocodile diversity in the Neogene of Africa, but relationships with their living relatives and the biogeographic origins of the modern African crocodylian fauna are poorly understood. A Plio-Pleistocene crocodile from Olduvai Gorge, Tanzania, represents a new extinct species and shows that high crocodylian diversity in Africa persisted after the Miocene. It had prominent triangular "horns" over the ears and a relatively deep snout, these resemble those of the recently extinct Malagasy crocodile Voay robustus, but the new species lacks features found among osteolaemines and shares derived similarities with living species of Crocodylus. METHODOLOGY/PRINCIPAL FINDINGS: The holotype consists of a partial skull and skeleton and was collected on the surface between two tuffs dated to approximately 1.84 million years (Ma), in the same interval near the type localities for the hominids Homo habilis and Australopithecus boisei. It was compared with previously-collected material from Olduvai Gorge referable to the same species. Phylogenetic analysis places the new form within or adjacent to crown Crocodylus. CONCLUSIONS/SIGNIFICANCE: The new crocodile species was the largest predator encountered by our ancestors at Olduvai Gorge, as indicated by hominid specimens preserving crocodile bite marks from these sites. The new species also reinforces the emerging view of high crocodylian diversity throughout the Neogene, and it represents one of the few extinct species referable to crown genus Crocodylus

Worst-case and Amortised Optimality in Union-Find (Extended Abstract)

We study the interplay between worst-case and amortised time bounds for the classic Disjoint Set Union problem (Union-Find). We ask whether it is possible to achieve optimal worst-case and amortised bounds simultaneously. Furthermore we would like to allow a tradeoff between the worst-case time for a query and for an update. We answer this question by first providing lower bounds for the possible worst-case time tradeoffs, as well as lower bounds which show where in this tradeoff range optimal amortised time is achievable. We then give an algorithm which tightly matches both lower bounds simultaneously. The lower bounds are provided in the cell-probe model as well as in the algebraic real-number RAM, and the upper bounds hold for a RAM with logarithmic word size and a modest instruction set. Our lower bounds show that for worst-case query and update time t q and t u respectively, one must have t q = 780 n= log t u ), and only for t q (m; n) can this tradeoff be achieved simultaneou..