Multicyclic treelike reflexive graphs

AbstractA simple graph is reflexive if its second largest eigenvalue does not exceed 2. A graph is treelike (sometimes also called a cactus) if all its cycles (circuits) are mutually edge-disjoint. In a lot of cases one can establish whether a given graph is reflexive by identifying and removing a single cut-vertex (Theorem 1). In this paper we prove that, if this theorem cannot be applied to a connected treelike reflexive graph G and if all its cycles do not have a common vertex (do not form a bundle), such a graph has at most five cycles (Theorem 2). On the same conditions, in Theorem 3 we find all maximal treelike reflexive graphs with four and five cycles

Geometric De-noising of Protein-Protein Interaction Networks

Understanding complex networks of protein-protein interactions (PPIs) is one of the foremost challenges of the post-genomic era. Due to the recent advances in experimental bio-technology, including yeast-2-hybrid (Y2H), tandem affinity purification (TAP) and other high-throughput methods for protein-protein interaction (PPI) detection, huge amounts of PPI network data are becoming available. Of major concern, however, are the levels of noise and incompleteness. For example, for Y2H screens, it is thought that the false positive rate could be as high as 64%, and the false negative rate may range from 43% to 71%. TAP experiments are believed to have comparable levels of noise