The Effect of Sintering Additive on Grain Growth in UO2 Nuclear Fuel Pellet

In this work, a powder with specific chemical and physical characteristics was used and the effect of different additives on grain growth and densification of UO2 pellets were studied. The mixture of powder and additives was pressed and then sintered under hydrogen atmosphere for 6 hours at 1700֩C. The Cr2O3 additive not only increased densification but also severely increased the grain size. Other additives had little effect on grain growth of the nuclear fuel pellets. Sintering behavior and Coarse-grained microstructure formation are discussed in terms of the reduction of Cr2O3 to Cr, the dissolution of Cr2O3 in UO2 and sintering

The Hybrid Power Flow Controller A New Concept for Flexible AC Transmission

Abstract-Two novel power flow controller topologies are proposed for flexible AC transmission systems (FACTS). The first one consists of a shunt connected source of reactive power, and two series connected voltage-sourced converters -one on each side of the shunt device. The second topology is a dual of the first; it is based on two shunt connected current-sourced converters around a series connected reactive element. In both cases the converters can exchange active power through a common DC circuit. Both topologies make combined use of passive components and converters and can therefore be regarded as hybrid. Employing hybrid topologies enables use of converters to enhance the functionality of existing equipment in a power system. The paper demonstrates that, by using appropriate converter additions and control, the functionality of switched shunt or series capacitors can be enhanced to generalized power flow control -a functionality commonly associated with the UPFC. Since existing equipment is fully utilized, the hybrid topology requires considerably lower total converter ratings compared to the UPFC

Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [18F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors version 1.0

PURPOSE: The goal of this guideline/procedure standard is to assist nuclear medicine physicians, other nuclear medicine professionals, oncologists or other medical specialists for recommended use of [ METHODS: In a cooperative effort between the EANM, the SNMMI and the ANZSNM, clinical indications, recommended imaging procedures and reporting standards have been agreed upon and summarized in this joint guideline/procedure standard. CONCLUSIONS: The field of immuno-oncology is rapidly evolving, and this guideline/procedure standard should not be seen as definitive, but rather as a guidance document standardizing the use and interpretation of [ PREAMBLE: The European Association of Nuclear Medicine (EANM) is a professional non-profit medical association founded in 1985 to facilitate worldwide communication among individuals pursuing clinical and academic excellence in nuclear medicine. The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote science, technology and practical application of nuclear medicine. The Australian and New Zealand Society of Nuclear Medicine (ANZSNM), founded in 1969, represents the major professional society fostering the technical and professional development of nuclear medicine practice across Australia and New Zealand. It promotes excellence in the nuclear medicine profession through education, research and a commitment to the highest professional standards. EANM, SNMMI and ANZSNM members are physicians, technologists, physicists and scientists specialized in the research and clinical practice of nuclear medicine. All three societies will periodically put forth new standards/guidelines for nuclear medicine practice to help advance the science of nuclear medicine and improve service to patients. Existing standards/guidelines will be reviewed for revision or renewal, as appropriate, on their fifth anniversary or sooner, if indicated. Each standard/guideline, representing a policy statement by the EANM/SNMMI/ANZSNM, has undergone a thorough consensus process, entailing extensive review. These societies recognize that the safe and effective use of diagnostic nuclear medicine imaging requires particular training and skills, as described in each document. These standards/guidelines are educational tools designed to assist practitioners in providing appropriate and effective nuclear medicine care for patients. These guidelines are consensus documents based on current knowledge. They are not intended to be inflexible rules or requirements of practice, nor should they be used to establish a legal standard of care. For these reasons and those set forth below, the EANM, SNMMI and ANZSNM caution against the use of these standards/guidelines in litigation in which the clinical decisions of a practitioner are called into question. The ultimate judgment regarding the propriety of any specific procedure or course of action must be made by medical professionals considering the unique circumstances of each case. Thus, there is no implication that an action differing from what is laid out in the guidelines/procedure standards, standing alone, is below standard of care. To the contrary, a conscientious practitioner may responsibly adopt a course of action different from that set forth in the standards/guidelines when, in the reasonable judgment of the practitioner, such course of action is indicated by the condition of the patient, limitations of available resources or advances in knowledge or technology subsequent to publication of the guidelines/procedure standards. The practice of medicine involves not only the science, but also the art of dealing with the prevention, diagnosis, alleviation and treatment of disease. The variety and complexity of human conditions make it impossible for general guidelines to consistently allow for an accurate diagnosis to be reached or a particular treatment response to be predicted. Therefore, it should be recognized that adherence to these standards/ guidelines will not ensure a successful outcome. All that should be expected is that practitioners follow a reasonable course of action, based on their level of training, current knowledge, clinical practice guidelines, available resources and the needs/context of the patient being treated. The sole purpose of these guidelines is to assist practitioners in achieving this objective. The present guideline/procedure standard was developed collaboratively by the EANM, the SNMMI and the ANZSNM, with the support of international experts in the field. They summarize also the views of the Oncology and Theranostics and the Inflammation and Infection Committees of the EANM, as well as the procedure standards committee of the SNMMI, and reflect recommendations for which the EANM and SNMMI cannot be held responsible. The recommendations should be taken into the context of good practice of nuclear medicine and do not substitute for national and international legal or regulatory provisions

Revisiting hydro-ecological impacts of climate change on a restored floodplain wetland via hydrological/hydraulic modelling and the UK Climate Projections 2018 scenarios

The hydro-ecological impacts of 40 UK Climate Projections 2018 scenarios on a restored lowland England river floodplain are assessed using a MIKE SHE / MIKE 11 model. Annual precipitation declines for 60% of scenarios (range: -26%–21%, with small, <5%, declines for the central probability level). Potential evapotranspiration increases for all probability levels except the most extreme, very unlikely, 10% level (range: -4%–43%, central probability 9%–20%) Mean, peak and low river discharges are reduced for all but the extreme 90% probability level. Reduced frequency of bankfull discharge dominates (at least halved for the central probability level). Floodplain inundation declines for over 97% of 320 scenario-events. Winter water table levels still intercept the surface, while mean and summer low levels are reduced. Declines in mean summer floodplain water table levels for the central probability level (0.22 m and 0.28 m for the 2050s and 2080s, respectively) are twice as large as those in the more dynamic riparian area. Declines reach 0.39 m for some 10% probability level scenarios. Simulated hydrological changes differ subtly from a previous assessment using earlier UK climate projections. A soil aeration stress index demonstrates that, under baseline conditions, prolonged high winter floodplain water tables drive long periods of low root-zone oxygen, in turn favouring vegetation communities adapted to waterlogged conditions. Climate change reduces aeration stress and the extent of appropriate conditions for these plant communities in favour of communities less tolerant of wet conditions

Joint EANM/SNMMI procedure guideline for the use of 177Lu-labeled PSMA-targeted radioligand-therapy (177Lu-PSMA-RLT)

Prostate-specific membrane antigen (PSMA) is expressed by the majority of clinically significant prostate adenocarcinomas, and patients with target-positive disease can easily be identified by PSMA PET imaging. Promising results with PSMA-targeted radiopharmaceutical therapy have already been obtained in early-phase studies using various combinations of targeting molecules and radiolabels. Definitive evidence of the safety and efficacy of [177Lu]Lu-PSMA-617 in combination with standard-of-care has been demonstrated in patients with metastatic castration-resistant prostate cancer, whose disease had progressed after or during at least one taxane regimen and at least one novel androgen-axis drug. Preliminary data suggest that 177Lu-PSMA-radioligand therapy (RLT) also has high potential in additional clinical situations. Hence, the radiopharmaceuticals [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMA-I&amp;T are currently being evaluated in ongoing phase 3 trials. The purpose of this guideline is to assist nuclear medicine personnel, to select patients with highest potential to benefit from 177Lu-PSMA-RLT, to perform the procedure in accordance with current best practice, and to prepare for possible side effects and their clinical management. We also provide expert advice, to identify those clinical situations which may justify the off-label use of [177Lu]Lu-PSMA-617 or other emerging ligands on an individual patient basis

Bio-nanotechnology application in wastewater treatment

The nanoparticles have received high interest in the field of medicine and water purification, however, the nanomaterials produced by chemical and physical methods are considered hazardous, expensive, and leave behind harmful substances to the environment. This chapter aimed to focus on green-synthesized nanoparticles and their medical applications. Moreover, the chapter highlighted the applicability of the metallic nanoparticles (MNPs) in the inactivation of microbial cells due to their high surface and small particle size. Modifying nanomaterials produced by green-methods is safe, inexpensive, and easy. Therefore, the control and modification of nanoparticles and their properties were also discussed