64 research outputs found
Decreased Na + /K + -ATPase activity and altered susceptibility to peroxidation and lipid composition in the erythrocytes of metabolic syndrome patients with coronary artery disease
Background: The increased generation of reactive oxygen species that occurs in the case of a metabolic syndrome (MetS) may be responsible for the increased oxidative injury to erythrocyte membranes in coronary artery disease (CAD). Therefore, we studied the effects of MetS on both indexes of oxidative damage and biochemical properties of erythrocyte membranes in CAD patients. Methods: We analyzed the markers of oxidative stress, Na + /K + -ATPase activity, total cholesterol content of erythrocyte membranes (CEM), and fatty acid compositions of the erythrocyte membrane in 82 patients with stable CAD and 39 non-CAD subjects. Results: The CAD patients had higher levels of CEM, membrane lipid peroxidation, erythrocyte superoxide dismutase (SOD) activity, and Na + /K + -ATPase activity compared with non-CAD subjects. The Na + /K + -ATPase activity was correlated negatively with membrane lipid peroxidation, and positively with the CEM. In CAD patients with MetS compared with those without MetS, we found that the membrane lipid peroxidation and CEM were increased, whereas the n-3 fatty acids content, SOD activity, Na + /K + -ATPase activity were decreased. Conclusion: These findings suggest an impairment of erythrocyte membrane biochemical properties in stable CAD patients as a consequence of oxidative injury that may contribute to the development of CAD. In addition, MetS may be related to increased oxidative injury to erythrocyte membranes. © 2019 S. Karger AG, Basel
New literacy challenge for the twenty-first century: genetic knowledge is poor even among well educated
We live in an age of rapidly advancing genetic research. This research is generating new knowledge that has implications for personal health and well-being. The present study assessed the level of genetic knowledge and personal engagement with genetics in a large sample (N = 5404) of participants. Participants received secondary education in 78 countries, with the largest samples from Russia, the UK and the USA. The results showed significant group differences in genetic knowledge between different countries, professions, education levels and religious affiliations. Overall, genetic knowledge was poor. The questions were designed to assess basic genetic literacy. However, only 1.2% of participants answered all 18 questions correctly, and the average score was 65.5%. Genetic knowledge was related to peoples’ attitudes towards genetics. For example, those with greater genetic knowledge were on average more willing to use genetic knowledge for their personal health management. Based on the results, the paper proposes a number of immediate steps that societies can implement to empower the public to benefit from everadvancing
genetic knowledge
The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results
#beta#-oxidation of dicarboxylates
Available from British Library Document Supply Centre-DSC:DXN026593 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
Normal acylcarnitines in maternal urine during a pregnancy affected by glutaric aciduria type II
Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle
Recent developments in the detection of inherited disorders of mitochondrial β-oxidation
Early diagnosis of neurometabolic diseases by tandem mass spectrometry. Acylcarnitine profile from cord blood
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