Cosmic ray drift, shock wave acceleration and the anomalous component of cosmic rays

A model of the anomalous component of the quiet-time cosmic ray flux is presented in which ex-interstellar neutral particles are accelerated continuously in the polar regions of the solar-wind termination shock, and then drift into the equatorial regions of the inner heliosphere. The observed solar-cycle variations, radial gradient, and apparent latitude gradient of the anomalous component are a natural consequence of this model

On the acceleration of ions by interplanetary shock waves. 1: Single encounter considerations

The acceleration of energetic ions in interplanetary magnetosonic fast-mode shock waves was studied via analytical modeling and numerical simulations. An analytical model that combines both the shock drift and compressional acceleration mechanisms is presented. The analytical predictions of the model are shown to be in good agreement with numerical simulation results

On the acceleration of ions by interplanetary shock waves. 3: High time resolution observations of CIR proton events

Observations within + or - 3 hours of corotating interaction region (CIR) shock waves of proton intensities, pitch angle distribution and crude differential energy spectra of the range of 0.6 E sub p 3.4 MeV are presented. The principle result is the evidence for the persistent flow of particles away from the shock. The observations are found to be in good agreement with the hypothesis of local interplanetary shock acceleration by the shock drift and compression mechanisms. The same set of observations strongly suggest that transit time damping does not play an important role in the acceleration of protons to 1 MeV in the immediate vicinity of CIR shocks

The outer source of pickup ions and anomalous cosmic rays

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95527/1/grl16222.pd

The Structure of a Rigorously Conserved RNA Element within the SARS Virus Genome

We have solved the three-dimensional crystal structure of the stem-loop II motif (s2m) RNA element of the SARS virus genome to 2.7-Å resolution. SARS and related coronaviruses and astroviruses all possess a motif at the 3′ end of their RNA genomes, called the s2m, whose pathogenic importance is inferred from its rigorous sequence conservation in an otherwise rapidly mutable RNA genome. We find that this extreme conservation is clearly explained by the requirement to form a highly structured RNA whose unique tertiary structure includes a sharp 90° kink of the helix axis and several novel longer-range tertiary interactions. The tertiary base interactions create a tunnel that runs perpendicular to the main helical axis whose interior is negatively charged and binds two magnesium ions. These unusual features likely form interaction surfaces with conserved host cell components or other reactive sites required for virus function. Based on its conservation in viral pathogen genomes and its absence in the human genome, we suggest that these unusual structural features in the s2m RNA element are attractive targets for the design of anti-viral therapeutic agents. Structural genomics has sought to deduce protein function based on three-dimensional homology. Here we have extended this approach to RNA by proposing potential functions for a rigorously conserved set of RNA tertiary structural interactions that occur within the SARS RNA genome itself. Based on tertiary structural comparisons, we propose the s2m RNA binds one or more proteins possessing an oligomer-binding-like fold, and we suggest a possible mechanism for SARS viral RNA hijacking of host protein synthesis, both based upon observed s2m RNA macromolecular mimicry of a relevant ribosomal RNA fold

A device for recording automatic audio tape recording1

Adaptation of a commercially available timer for use as a means of operating an audio tape recorder several times during the day is described. Data on a mother's rates of commanding her children were collected via both physically present observer and recorder methods in order to compare the usefulness of the recordings with direct observation. There was a high positive relationship between observer-recorder command rates, with the observer rates being consistently higher, when data were collected via both methods simultaneously as well as at different points in time