Changes in forward light scatter parameters as a function of refractive error in young adults

Background/aims Some aspects of visual performance worsen with increasing myopia. Whilst the underlying causes are not always clear, reduction in retinal image quality is often attributed to structural changes in the posterior myopic eye. Forward light scatter, originating principally from the cornea and lens, is known to produce veiling glare which subsequently reduces retinal image contrast. It is therefore of interest to investigate whether forward light scatter varies with refractive error. Methods Thirteen young-adult subjects (18–25 years), with mean spherical errors (MSE ± sd, D) RE, − 1.69 ± 2.02 (range 0.38 to − 4.75); LE, − 1.91 ± 1.94 (range 0.50 to − 4.63) underwent binocular assessment of forward light scatter using the AVOT light scatter test. Five glare annuli, with effective eccentricities ranging from 2 to 10°, were used to estimate parameters, k and n, which define the light scatter function of the eye. These were then used to calculate the area under the light scatter function (k′) and the total volume of light scatter (k″). Results Significant correlation was found between increasing myopia and k′ values (RE, p  0.05 for both eyes). Axial length was also not correlated with any of the light scatter parameters measured. Conclusion The preliminary data from this study provide evidence that some light scatter parameters may be correlated with refractive error. Further studies are needed to characterize how changes in the anterior media of the eye, and inclusion of a wider range of refractive errors, may affect forward light scatter

Web-based information systems development and dynamic organisational change: the need for emergent development tools

This paper considers contextual issues relating to the problem of developing web-based information systems in and for emergent organisations. It postulates that the methods available suffer because of sudden and unexpected changing characteristics within the organisation. The Theory of Deferred Action is used as the basis for the development of an emergent development tool. Many tools for managing change in a continuously changing organisation are susceptible to inadequacy. The insights proposed are believed to assist designers in developing functional and relevant approaches within dynamic organisational contexts

Sterile Neutrino Hot, Warm, and Cold Dark Matter

We calculate the incoherent resonant and non-resonant scattering production of sterile neutrinos in the early universe. We find ranges of sterile neutrino masses, vacuum mixing angles, and initial lepton numbers which allow these species to constitute viable hot, warm, and cold dark matter (HDM, WDM, CDM) candidates which meet observational constraints. The constraints considered here include energy loss in core collapse supernovae, energy density limits at big bang nucleosynthesis, and those stemming from sterile neutrino decay: limits from observed cosmic microwave background anisotropies, diffuse extragalactic background radiation, and Li-6/D overproduction. Our calculations explicitly include matter effects, both effective mixing angle suppression and enhancement (MSW resonance), as well as quantum damping. We for the first time properly include all finite temperature effects, dilution resulting from the annihilation or disappearance of relativistic degrees of freedom, and the scattering-rate-enhancing effects of particle-antiparticle pairs (muons, tauons, quarks) at high temperature in the early universe.Comment: 24 pages, including 8 figures. v3: to match version in PRD, added references and numerous minor changes. High resolution color figures available at http://superbeast.ucsd.edu/~kev/nucd

Discrete symmetries for electroweak natural type-I seesaw mechanism

The naturalness of electroweak scale in the models of type-I seesaw mechanism with ${\cal O}(1)$ Yukawa couplings requires TeV scale masses for the fermion singlets. In this case, the tiny neutrino masses have to arise from the cancellations within the seesaw formula which are arranged by fine-tuned correlations between the Yukawa couplings and the masses of fermion singlets. We motivate such correlations through the framework of discrete symmetries. In the case of three Majorana fermion singlets, it is shown that the exact cancellation arranged by the discrete symmetries in seesaw formula necessarily leads to two mass degenerate fermion singlets. The remaining fermion singlet decouples completely from the standard model. We provide two candidate models based on the groups $A_4$ and $\Sigma(81)$ and discuss the generic perturbations to this approach which can lead to the viable neutrino masses.Comment: 26 pages, 4 figures; references added, matches published versio

Interpreting 750 GeV diphoton excess in SU(5) grand unified theory

The ATLAS and CMS experiments at the LHC have found significant excess in the diphoton invariant mass distribution near 750 GeV. We interpret this excess in a predictive nonsupersymmetric SU(5) grand unified framework with a singlet scalar and light adjoint fermions. The 750 GeV resonance is identified as a gauge singlet scalar. Both its production and decays are induced by 24 dimensional adjoint fermions predicted within SU(5). The adjoint fermions are assumed to be odd under $Z_2$ symmetry which forbids their direct coupling to the standard model fermions. We show that the observed diphoton excess can be explained with sub-TeV adjoint fermions and with perturbative Yukawa coupling. A narrow width scenario is more preferred while a simultaneous explanation of observed cross section and large total decay width requires some of the adjoint fermions lighter than 375 GeV. The model also provides a singlet fermion as a candidate of cold dark matter. The gauge coupling unification is achieved in the framework by introducing color sextet scalars while being consistent with the proton decay constraint.Comment: Discussion added, conclusion unchanged; Matches published version in Physics Letters