Abstract Images Have Different Levels of Retrievability Per Reverse Image Search Engine

Much computer vision research has focused on natural images, but technical documents typically consist of abstract images, such as charts, drawings, diagrams, and schematics. How well do general web search engines discover abstract images? Recent advancements in computer vision and machine learning have led to the rise of reverse image search engines. Where conventional search engines accept a text query and return a set of document results, including images, a reverse image search accepts an image as a query and returns a set of images as results. This paper evaluates how well common reverse image search engines discover abstract images. We conducted an experiment leveraging images from Wikimedia Commons, a website known to be well indexed by Baidu, Bing, Google, and Yandex. We measure how difficult an image is to find again (retrievability), what percentage of images returned are relevant (precision), and the average number of results a visitor must review before finding the submitted image (mean reciprocal rank). When trying to discover the same image again among similar images, Yandex performs best. When searching for pages containing a specific image, Google and Yandex outperform the others when discovering photographs with precision scores ranging from 0.8191 to 0.8297, respectively. In both of these cases, Google and Yandex perform better with natural images than with abstract ones achieving a difference in retrievability as high as 54\% between images in these categories. These results affect anyone applying common web search engines to search for technical documents that use abstract images.Comment: 20 pages; 7 figures; to be published in the proceedings of the Drawings and abstract Imagery: Representation and Analysis (DIRA) Workshop from ECCV 202

Discovering Image Usage Online: A Case Study With "Flatten the Curve''

Understanding the spread of images across the web helps us understand the reuse of scientific visualizations and their relationship with the public. The "Flatten the Curve" graphic was heavily used during the COVID-19 pandemic to convey a complex concept in a simple form. It displays two curves comparing the impact on case loads for medical facilities if the populace either adopts or fails to adopt protective measures during a pandemic. We use five variants of the "Flatten the Curve" image as a case study for viewing the spread of an image online. To evaluate its spread, we leverage three information channels: reverse image search engines, social media, and web archives. Reverse image searches give us a current view into image reuse. Social media helps us understand a variant's popularity over time. Web archives help us see when it was preserved, highlighting a view of popularity for future researchers. Our case study leverages document URLs can be used as a proxy for images when studying the spread of images online.Comment: 6 pages, 5 figures, Presented as poster at JCDL 202

Fracture Toughness of Fibrous Membranes

Random fibrous networks exist in both natural biological and engineering materials. While the nonlinear deformation of fibrous networks has been extensively studied, the understanding of their fracture behaviour is still incomplete. To study the fracture toughness of fibrous materials, the near-tip region is crucial because failure mechanisms such as fibril rupture occur in this region. The consideration of this region in fracture studies is, however, a difficult task because it involves microscopic mechanical responses at a small length scale. This paper extends our previous finite element analysis by incorporating the microscopic responses into a macroscopic domain by using a submodeling technique. The detailed study of microstructures at crack tips show a stochastic toughness of membranes due to the random nature of fibrous networks. Further, the sizes of crack tip region, which are sufficient to provide a reasonable prediction of fracture behaviour in a specific type of fibrous network, were presented. Future work includes improving the current linear assumption in the macroscopic models to become nonlinear

Radiopharmaceuticals in the elderly cancer patient: Practical considerations, with a focus on prostate cancer therapy: A position paper from the International Society of Geriatric Oncology Task Force.

Molecular imaging using radiopharmaceuticals has a clear role in visualising the presence and extent of tumour at diagnosis and monitoring response to therapy. Such imaging provides prognostic and predictive information relevant to management, e.g. by quantifying active tumour mass using positron emission tomography/computed tomography (PET/CT). As these techniques require only pharmacologically inactive doses, age and potential frailty are generally not important. However, this may be different for therapy involving radionuclides because the radiation can impact normal bodily function (e.g. myelosuppression). Since the introduction of Iodine-131 as a targeted therapy in thyroid cancer, several radiopharmaceuticals have been widely used. These include antibodies and peptides targeting specific epitopes on cancer cells. Among therapeutic bone seeking agents, radium-223 ((223)Ra) stands out as it results in survival gains in patients with castration-resistant prostate cancer and symptomatic bone metastases. The therapeutic use of radiopharmaceuticals in elderly cancer patients specifically has received little attention. In elderly prostate cancer patients, there may be advantages in radionuclides' ease of use and relative lack of toxicity compared with cytotoxic and cytostatic drugs. When using radionuclide therapies, close coordination between oncology and nuclear medicine is needed to ensure safe and effective use. Bone marrow reserve has to be considered. As most radiopharmaceuticals are cleared renally, dose adjustment may be required in the elderly. However, compared with younger patients there is less, if any, concern about adverse long-term radiation effects such as radiation-induced second cancers. Issues regarding the safety of medical staff, care givers and the wider environment can be managed by current precautions

Spherical indentation of a finite poroelastic coating

Indentation testing of a finite poroelastic layer is considered. Finite element modeling was used to investigate spherical contact creep tests, with emphasis on the influence of layer thickness and of finite rise time on the time-dependent deformation. Thin layers are stiffened by the substrate constraint even at very small relative indenter penetrations and reach steady state more quickly than thick layers. The degree of consolidation following loading is affected by the interaction of layer thickness and rise time and cannot be predicted from either alone. These results provide guidance for micro- and nanoindentation testings of hydrogel coatings for biomedical applications

Collagen type IV at the fetal-maternal interface.

INTRODUCTION: Extracellular matrix proteins play a crucial role in influencing the invasion of trophoblast cells. However the role of collagens and collagen type IV (col-IV) in particular at the implantation site is not clear. METHODS: Immunohistochemistry was used to determine the distribution of collagen types I, III, IV and VI in endometrium and decidua during the menstrual cycle and the first trimester of pregnancy. Expression of col-IV alpha chains during the reproductive cycle was determined by qPCR and protein localisation by immunohistochemistry. The structure of col-IV in placenta was examined using transmission electron microscopy. Finally, the expression of col-IV alpha chain NC1 domains and collagen receptors was localised by immunohistochemistry. RESULTS: Col-IV alpha chains were selectively up-regulated during the menstrual cycle and decidualisation. Primary extravillous trophoblast cells express collagen receptors and secrete col-IV in vitro and in vivo, resulting in the increased levels found in decidua basalis compared to decidua parietalis. A novel expression pattern of col-IV in the mesenchyme of placental villi, as a three-dimensional network, was found. NC1 domains of col-IV alpha chains are known to regulate tumour cell migration and the selective expression of these domains in decidua basalis compared to decidua parietalis was determined. DISCUSSION: Col-IV is expressed as novel forms in the placenta. These findings suggest that col-IV not only represents a structural protein providing tissue integrity but also influences the invasive behaviour of trophoblast cells at the implantation site.This work was supported by funding from the Wellcome Trust [090108/Z/09/Z], [085992/Z/08/Z] and the British Heart Foundation [PG/09/077/27964]. C.M. Oefner was in receipt of a German National Academic Foundation PhD studentship. The authors also thank the Centre for Trophoblast Research for generous support.This is the final published version of the article. It first appeared at http://www.sciencedirect.com/science/article/pii/S0143400414008248#

Supply Chain Disruption Costs Study in International Containerised Maritime Transportation

The global economy relies highly on international trade, and the international maritime transport system acts as the lifeblood carrying and transporting materials and goods globally, realizing the economy globalization in an effective and efficient way. However, globalization increases the interdependence and complexity of global supply chains and drives it to be more vulnerable to disruptions. Meanwhile, the international marine transport system is a complex and intertwined system exposed to high risks and decreased safety due to its very accessibility and operational flexibility. Thereby, global supply chains integrated with international maritime transportation systems are inherently vulnerable to various disruptions. Studies of supply chain disruptions particularly quantifying transport related disruption costs are becoming increasingly important. However, research on maritime transport related supply chain disruptions, in particular, quantifying its disruption costs is under-represented in the transport literature, due largely to the features of supply chain disruptions, but also because of the complexity of maritime related supply chains. Current research in transportation has tended to concentrate on shippers’ transport mode choice and port selection. In the context of a global market, however, the behaviour of maritime containerised shippers has to be viewed as a complex decision and an integral element of the supply chain management strategy. Those shippers’ transportation choice decisions should be emphasized and studied to reveal their behaviour changes between normal operations and disruption circumstance. This research adds to the paucity work on investigating the maritime transport related supply chain disruptions and quantifying its disruption costs based on shippers’ maritime transportation choice behaviour. It presents the results of a microanalysis of freight transport choice decisions in an international containerised maritime transport chain context. The Latent Class Model (LCM) is applied to identify the key service attributes and its preference heterogeneity in maritime transportation and to estimate the marginal values for the quality of maritime transport service with and without a disruption, simultaneously, quantifying the disruption costs through comparing each attribute’s marginal value difference between normal and disruption operations. The Seemingly Unrelated Regression model (SURE) is utilized to explore the sources influencing shippers’ preference heterogeneities. In doing so, we are able to gain an understanding as to where and how much should be invested in order to facilitate recovery in the case of a disruption based on the view of the maritime participants’ perspectives. The research results confirm freight rate, transit time, reliability, damage rate, and frequency as the key service attributes influencing shippers’ transport choice. They also reveal shippers’ VOT increase by more than four-times, VOR nearly double, and VOD increase about twenty percent if a disruption takes place, and identify shippers’ transport decisions vary with its product, shipment, company and supply chain characteristics no matter with or without a disruption. This research quantifies the costs of supply chain disruption in containerised maritime transport context for the first time, and its results provide useful industrial implications for maritime transport chain related parties

Raman spectroscopy reveals new insights into the zonal organization of native and tissue-engineered articular cartilage

Tissue architecture is intimately linked with its functions, and loss of tissue organization is often associated with pathologies. The intricate depth-dependent extracellular matrix (ECM) arrangement in articular cartilage is critical to its biomechanical functions. In this study, we developed a Raman spectroscopic imaging approach to gain new insight into the depth-dependent arrangement of native and tissue-engineered articular cartilage using bovine tissues and cells. Our results revealed previously unreported tissue complexity into at least six zones above the tidemark based on a principal component analysis and k-means clustering analysis of the distribution and orientation of the main ECM components. Correlation of nanoindentation and Raman spectroscopic data suggested that the biomechanics across the tissue depth are influenced by ECM microstructure rather than composition. Further, Raman spectroscopy together with multivariate analysis revealed changes in the collagen, glycosaminoglycan and water distributions in tissue-engineered constructs over time. These changes were assessed using simple metrics that promise to instruct efforts towards the regeneration of a broad range of tissues with native zonal complexity and functional performance