Neurovascular relationships in uterine wall in adenomyosis complicated with pelvic pain syndrome

Background. Pelvic pain is one of the most frequent complications of adenomiosis. Objective. To investigate the neurovascular relationships in uterine adenomyosis complicated with pelvic pain syndrome. Methods. Material was received after hysterectomy from 16 patients of reproductive age with diffuse adenomyosis of 2-3 degrees in the phase of proliferation. The group of comparison included the material obtained from patients with asymptomatic leiomyoma. Morphological and immunohistochemical methods were used. Results. An increase in nerve number and density was demonstrated in perivascular region around ectopic endometrium as well as in zones of myometrium remodeling in patients with adenomyosis (p <0,001). Nerve growth was associated with degenerative changes in the uterine vessels, lack of -SMA expression and reduction of estrogen receptors in arteries. These changes were accompanied with stimulation of angiogenesis and increased expression of vascular endothelial growth factor VEGF (p<0,01). The main sources of VEGF were ectopic endometrium epithelium and inflammatory cells in areas of myometrium remodeling. Conclusion. Remodeling of vascular bed and endometrium on the background of dystrophic changes of large vessels and increased VEGF expression could be one of the factors determining nerve growth in uterine adenomyosis. Citation: Orazov M, Sulaeva ON, Nosenko EN. [Neurovascular relationships in uterine wall in adenomyosis complicated with pelvic pain syndrome]. Morphologia. 2015;9(1):52-57. Russian

Options for overcoming implantation failures in infertility of uterine genesis due to chronic endometritis. A review

Chronic endometritis remains one of the most controversial issues of modern gynecology. The high relevance of research in this area is confirmed not only by the high prevalence but also by the extremely negative impact of this disease on the reproductive potential of patients. The complexity of the pathogenesis mechanism of the chronic inflammatory process of the endometrium stimulates the genuine interest of the world gynecological community to study the main patterns of endometrial receptor disorder, including implantation status and repeated reproductive failures. In this regard, it is essential to summarize the accumulated results of worldwide research to find the most optimal and effective diagnostic and therapeutic approaches

Self-Pillared, Single-Unit-Cell Sn-MFI Zeolite Nanosheets and Their Use for Glucose and Lactose Isomerization

Single-unit-cell Sn-MFI, with the detectable Sn uniformly distributed and exclusively located at framework sites, is reported for the first time. The direct, single-step, synthesis is based on repetitive branching caused by rotational intergrowths of single-unit-cell lamellae. The self-pillared, meso- and microporous zeolite is an active and selective catalyst for sugar isomerization. High yields for the conversion of glucose into fructose and lactose to lactulose are demonstrated

D'Alembert sums for vibrating bar with viscous ends

We describe a new method for finding analytic solutions to some initial-boundary problems for partial differential equations with constant coefficients. The method is based on expanding the denominator of the Laplace transformed Green's function of the problem into a convergent geometric series. If the denominator is a linear combination of exponents with real powers one obtains a closed form solution as a sum with finite but time dependent number of terms. We call it a d'Alembert sum. This representation is computationally most effective for small evolution times, but it remains valid even when the system of eigenmodes is incomplete and the eigenmode expansion is unavailable. Moreover, it simplifies in such cases. In vibratory problems d'Alembert sums represent superpositions of original and partially reflected traveling waves. They generalize the d'Alembert type formulas for the wave equation, and reduce to them when original waves can undergo only finitely many reflections in the entire course of evolution. The method is applied to vibrations of a bar with dampers at each end and at some internal point. The results are illustrated by computer simulations and comparisons to modal and FEM solutions.Comment: 18 pages, 8 figure

A review of international and national clinical guidelines for the management of patients with endometrial polyps

Endometrial polyp (EP) is a common disease of the uterine mucosa in reproductive age, peri- and post-menopause. Hysteroscopy is the primary method of diagnosing EP, and polypectomy is the method of choice for treatment. Despite many years of research on EP, there are still gaps in the understanding of its pathogenesis; approaches to the diagnosis and therapy of EP are not standardized, which makes it difficult for gynecologists to make informed decisions about the management of patients with this disease. It determined the focus of our work. We reviewed clinical guidelines for EP diagnosis and treatment from the American Society of Gynecological Endoscopy, the Norwegian Society for Gynecology and Obstetrics, the draft clinical guidelines "Endometrial polyps" from the Russian Society for Obstetrics and Gynecology (as of July 28, 2022, not approved by the Russian Ministry of Health); as well as the Royal College of Obstetricians and Gynecologists guideline on the management of women with endometrial hyperplasia. The review has led to the conclusion that the recommendations in the current clinical guidelines for the management of women with EP are inconsistent and the diagnostic algorithm for suspected EP is not well-established; the indications for the wait-and-see, surgical treatment of EP are not defined; criteria of high oncological risk requiring surgical treatment of EP are not formulated. Clarifying these issues will help gynecologists make informed decisions about treatment options

Pillared Sn-MWW Prepared by a Solid-State-Exchange Method and its Use as a Lewis Acid Catalyst

Pillared Sn-MWW (Sn-MWW(SP)-SSE) was prepared through a solid-state-exchange (SSE) route. The pillared structure was inherited from pillared B-MWW, and Sn was inserted in the framework by boron leaching and solid-state-exchange with tin tetrachloride pentahydrate. The Sn-MWW(SP)-SSE with framework Sn sites exhibits Lewis acidity and good catalytic performance for the Baeyer–Villiger oxidation, and mono- and disaccharide isomerizations

The development of technology and research of quality indicators of nachos from non-traditional raw materials

Currently, due to lifestyle changes, ready-made snacks are a popular and in-demand food product. The use of a large number of snacks leads to the development of a number of negative changes in human health. According to WHO, diseases of the gastrointestinal tract are among the five most common diseases in the world. Most often these diseases affect children, preschool, school age and students. The reason for this may be, first of all, the uncontrolled use of «dry rations», that is, various types of snacks. But snacks can serve as a technological basis for designing innovative food products with excellent consumer characteristics (organoleptic and physico-chemical properties). Therefore, replacing the harmful component of snacks with balanced raw materials, a useful product is obtained. The article describes the technology of nachos obtained by changing the component of the recipe, and with the addition of unconventional raw materials. When preparing nachos, cottage cheese was used to increase its nutritional value. To check the quality indicators of raw materials and finished products, standard visual-sensory and laboratory research methods were used, the results of the studies were described in detail and recorded. To date, the most common fast food product as an alternative to chips has been offered Mexican nachos. Non-traditional raw materials and natural additives were included in the nachos recipe. As an unconventional raw material, cottage cheese was chosen as the main component according to the recipe. Cottage cheese, fat content 4.1%, was obtained from natural cow's milk by fermentation by thermophilic bacteria. The article presents a balanced nachos recipe. According to the calculated recipe, the nachos product was prepared. The organoleptic and qualitative indicators of raw materials and finished products are determined. According to the results of the studies, the lead content in nachos was 0.019 mg/kg, cadmium-0.003 mg/kg, manganese-0.051 mg/kg and iron-0.038 mg/kg. The results obtained comply with the requirements of regulatory documentation. At the same time, the protein content in the finished product was 9.6 g, fat 5 g, carbohydrates 40.9 g, total energy value-249.67 kcal. The results of the study actually showed that there are grounds to recommend nachos on the market as alternates for fast food products

Mass-modulation schemes for a class of wave energy converters: Experiments, models, and efficacy

In a recent series of works, mass-modulation schemes have been proposed for a class of ocean wave energy converter (WEC). The goal of the schemes is to improve the energy harvesting capabilities of these devices by taking advantage of the ambient water. However this improvement comes at the cost of increased system complexity and possible impulse loadings at the instances where the mass changes. In the present work, experimental results for a pair of these schemes are presented and one of them is shown to be effective in increasing the energy harvesting potential of a WEC. Building and testing prototype WECs are costly and challenging and so, in order to examine as wide a range of parameters and designs as possible, a detailed two degree-of-freedom model is developed for a WEC equipped with a mass-modulation scheme. Numerical analysis of the model also shows the potential benefits of the mass-modulation scheme

Neurovascular relationships in uterine wall in adenomyosis complicated with pelvic pain syndrome

В работе проведен морфологический и иммуногистохимический анализ нейрососудистых отношений в стенке матки при аденомиозе, осложненном синдромом тазовой боли. Материал получен после гистерэктомии от 16 пациенток репродуктивного возраста с диффузным аденомиозом 2-3 степени в фазе пролиферации. В группу сравнения вошел материал, полученный от пациенток аналогичного возраста с бессимптомной лейомиомой. При морфологическом исследовании стенки матки при аденомиозе установлено увеличение количества нервов вокруг крупных сосудов, в зонах ремоделирования миометрия и вблизи эктопического эндометрия (p <0,001). Рост нервов был ассоциирован с дистрофическими изменениями маточных сосудов, снижением их сенситивности к эстрогенам при стимуляции ангиогенеза на фоне повышенной экспрессии фактора роста сосудистого эндотелия VEGF (p<0,01). Основными источниками VEGF были эпителий эктопического эндометрия и клетки в зонах воспалительного ремоделирования миометрия.Pelvic pain is one of the most frequent complications of adenomiosis. Objective. To investigate the neurovascular relationships in uterine adenomyosis complicated with pelvic pain syndrome. Methods. Material was received after hysterectomy from 16 patients of reproductive age with diffuse adenomyosis of 2-3 degrees in the phase of proliferation. The group of comparison included the material obtained from patients with asymptomatic leiomyoma. Morphological and immunohistochemical methods were used. Results. An increase in nerve number and density was demonstrated in perivascular region around ectopic endometrium as well as in zones of myometrium remodeling in patients with adenomyosis (p <0,001). Nerve growth was associated with degenerative changes in the uterine vessels, lack of α-SMA expression and reduction of estrogen receptors in arteries. These changes were accompanied with stimulation of angiogenesis and increased expression of vascular endothelial growth factor VEGF (p<0,01). The main sources of VEGF were ectopic endometrium epithelium and inflammatory cells in areas of myometrium remodeling. Conclusion. Remodeling of vascular bed and endometrium on the background of dystrophic changes of large vessels and increased VEGF expression could be one of the factors determining nerve growth in uterine adenomyosis

Basic mechanisms of innervation compartment myometrium in women with chronic pelvic pain syndrome in adenomyosis

Работа посвящена одной из актуальных проблем гинекологии – проблеме хронических тазовых болей. Целью представленной работы явилась иммуногистохимическая оценка состояния иннервационного аппарата и нейро-тканевых отношений в 60 матках, полученных после гистерэктомии от пациенток с диффузным аденомиозом ІІ–ІІІ степени, сопровождающимся выраженным болевым синдромом. Визуализацию нервных волокон проводили с использованием моноклональных антител к белкам нейрофиламентов. На основании полученных результатов авторы делают вывод о том, что основным носителем нервов в матке и потенциальной причиной формирования гипералгезии при аденомиозе является миометрий с формированием аномально избыточного иннервационного аппарата вокруг очагов эктопического эндометрия, в периваскулярных регионах и в строме между пучками гладких миоцитов.Te work is dedicated to one of the urgent problems gynecology - the problem of chronic pelvic pain.Te aim of presented work was immunohistochemical assessment innervational apparatus and neuro-tissue relations 60 ewes received afer hysterectomy from patients with diffuse adenomyosis II-III degree, accompanied by severe pain. Visualization of nerve fbers was performed using monoclonal antibodies to proteins of neuroflaments. Based on these results the authors conclude that the main carrier of the nerves in the uterus and a potential cause of the formation of hyperalgesia when adenomyosis is the myometrium with the formation of abnormally excessive innervation apparatus around foci of ectopic endometrium in perivascular regions and in the stroma between bundles of smooth myocytes