9,807 research outputs found
Summary results of the DOE flywheel development effort
The technology and applications evaluation task focuses on defining performance and cost requirements for flywheels in the various areas of application. To date the DOE program has focused on automotive applications. The composite materials effort entails the testing of new commercial composites to determine their engineering properties. The rotor and containment development work uses data from these program elements to design and fabricate flywheels. The flywheels are then tested at the Oak Ridge Flywheel Evaluation Laboratory and their performance is evaluated to indicate possible areas for improvement. Once a rotor has been fully developed it is transferred to the private sector
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized. It was suggested that it is important for the supply of reducing equivalents during intra-erythrocytic development of Plasmodium and, therefore, a suitable drug target.</p>
<p>Methods: The gene encoding the NADP(H)-dependent GDHa has been disrupted by reverse genetics in P. falciparum and the effect on the antioxidant and metabolic capacities of the resulting mutant parasites was investigated.</p>
<p>Results: No growth defect under low and elevated oxygen tension, no up-or down-regulation of a number of antioxidant and NADP(H)-generating proteins or mRNAs and no increased levels of GSH were detected in the D10(Delta gdha) parasite lines. Further, the fate of the carbon skeleton of [(13)C] labelled glutamine was assessed by metabolomic studies, revealing no differences in the labelling of a-ketoglutarate and other TCA pathway intermediates between wild type and mutant parasites.</p>
<p>Conclusions: First, the data support the conclusion that D10(Delta gdha) parasites are not experiencing enhanced oxidative stress and that GDHa function may not be the provision of NADP(H) for reductive reactions. Second, the results imply that the cytosolic, NADP(H)-dependent GDHa protein is not involved in the oxidative deamination of glutamate but that the protein may play a role in ammonia assimilation as has been described for other NADP(H)dependent GDH from plants and fungi. The lack of an obvious phenotype in the absence of GDHa may point to a regulatory role of the protein providing glutamate (as nitrogen storage molecule) in situations where the parasites experience a limiting supply of carbon sources and, therefore, under in vitro conditions the enzyme is unlikely to be of significant importance. The data imply that the protein is not a suitable target for future drug development against intra-erythrocytic parasite development.</p>
The Velocity Dispersion Profile of the Remote Dwarf Spheroidal Galaxy Leo I: A Tidal Hit and Run?
(abridged) We present kinematic results for a sample of 387 stars located
near Leo I based on spectra obtained with the MMT's Hectochelle spectrograph
near the MgI/Mgb lines. We estimate the mean velocity error of our sample to be
2.4 km/s, with a systematic error of < 1 km/s. We produce a final sample of 328
Leo I red giant members, from which we measure a mean heliocentric radial
velocity of 282.9 +/- 0.5 km/s, and a mean radial velocity dispersion of 9.2
+/- 0.4 km/s for Leo I. The dispersion profile of Leo I is flat out to beyond
its classical `tidal' radius. We fit the profile to a variety of equilibrium
dynamical models and can strongly rule out models where mass follows light.
Two-component Sersic+NFW models with tangentially anisotropic velocity
distributions fit the dispersion profile well, with isotropic models ruled out
at a 95% confidence level. The mass and V-band mass-to-light ratio of Leo I
estimated from equilibrium models are in the ranges 5-7 x 10^7 M_sun and 9-14
(solar units), respectively, out to 1 kpc from the galaxy center. Leo I members
located outside a `break radius' (about 400 arcsec = 500 pc) exhibit
significant velocity anisotropy, whereas stars interior appear to have
isotropic kinematics. We propose the break radius represents the location of
the tidal radius of Leo I at perigalacticon of a highly elliptical orbit. Our
scenario can account for the complex star formation history of Leo I, the
presence of population segregation within the galaxy, and Leo I's large outward
velocity from the Milky Way. The lack of extended tidal arms in Leo I suggests
the galaxy has experienced only one perigalactic passage with the Milky Way,
implying that Leo I may have been injected into its present orbit by a third
body a few Gyr before perigalacticon.Comment: ApJ accepted, 23 figures, access paper as a pdf file at
  http://www.astro.lsa.umich.edu/~mmateo/research.htm
Structure of the Draco Dwarf Spheroidal Galaxy
This article studies the structure of the Draco dwarf spheroidal galaxy with
an emphasis on the question of whether the spatial distribution of its stars
has been affected by the tidal interaction with the Milky Way, using R- and
V-band CCD photometry for eleven fields. The article reports coordinates for
the center, a position angle of the major axis, and the ellipticity. It also
reports the results of searches for asymmetries in the structure of Draco.
These results, and searches for a ``break'' in the radial profile and for the
presence of principal sequences of Draco in a color-magnitude diagram for
regions more than 50 arcmin from the center, yield no evidence that tidal
forces from the Milky Way have affected the structure of Draco.Comment: 25 pages, 11 figures, 3 tables. Accepted for publication in A
Rotational transition, domain formation, dislocations and defects in vortex systems with combined six- and 12-fold anisotropic interactions
We introduce a new model for a pairwise repulsive interaction potential of
vortices in a type-II superconductor, consisting of superimposed six- and
12-fold anisotropies. Using numerical simulations we study how the vortex
lattice configuration varies as the magnitudes of the two anisotropic
interaction terms change. A triangular lattice appears for all values, and
rotates through 30 degrees as the ratio of the six- and 12-fold anisotropy
amplitudes is varied. The transition causes the VL to split into domains that
have rotated clockwise or counter-clockwise, with domain boundaries that are
"decorated" by dislocations consisting of five- and seven-fold coordinated
vortices. We also find intra-domain dislocations and defects, and characterize
them in terms of their energy cost. We discuss how this model could be
generalized to other particle-based systems with anisotropic interactions, such
as colloids, and consider the limit of very large anisotropy where it is
possible to create cluster crystal states.Comment: 15 pages, 13 figures; minor revisions throughout tex
On Kinematic Substructure in the Sextans Dwarf Spheroidal Galaxy
We present multifiber echelle radial velocity results for 551 stars in the
Sextans dwarf spheroidal galaxy and identify 294 stars as probable Sextans
members. The projected velocity dispersion profile of the binned data remains
flat to a maximum angular radius of . We introduce a nonparametric
technique for estimating the projected velocity dispersion surface, and use
this to search for kinematic substructure. Our data do not confirm previous
reports of a kinematically distinct stellar population at the Sextans center.
Instead we detect a region near the Sextans core radius that is kinematically
colder than the overall Sextans sample with 95% confidence.Comment: accepted for publication in ApJ Letters; 4 figures (2 color
NGC 1866: First Spectroscopic Detection of Fast Rotating Stars in a Young LMC Cluster
High-resolution spectroscopic observations were taken of 29 extended main
sequence turn-off (eMSTO) stars in the young (200 Myr) LMC cluster, NGC
1866 using the Michigan/Magellan Fiber System and MSpec spectrograph on the
Magellan-Clay 6.5-m telescope. These spectra reveal the first direct detection
of rapidly rotating stars whose presence has only been inferred from
photometric studies. The eMSTO stars exhibit H-alpha emission (indicative of
Be-star decretion disks), others have shallow broad H-alpha absorption
(consistent with rotation 150 km s), or deep H-alpha core
absorption signaling lower rotation velocities (150 km s ).
The spectra appear consistent with two populations of stars - one rapidly
rotating, and the other, younger and slowly rotating.Comment: 9 pages, 4 figures, Accepted for publication in ApJ Letter
M\"ossbauer studies of powdered single crystals of FeTe0.5Se0.5
The M\"ossbauer measurements performed on powdered single crystals of
FeTe0.5Se0.5 (Tc ~ 14.7 K) reveal minor content of two impurity phases,
identified as Fe3O4 and Fe7Se8, among the major tetragonal phase. From the
shape of impurity subspectra it follows that Fe7Se8 behaves in
superparamagnetic manner, most likely because of randomly distributed Fe
vacancies in the lattice structure of Fe Te Se. The magnetite content in the
powdered absorber exposed to ambient air conditions remains unchanged during
period of 16 months. Ageing effects were observed for the samples stored under
argon atmosphere and small increase of the isomer shift of the doublet was
detected. Presented temperature dependence of the hyperfine parameters can be
explained as due to possible orthorhombic distortion or to temperature
behaviour of impurity phases Fe3O4 and Fe7Se8. Strong tendency to formation of
crystalline texture of powdered sample is observed.Comment: 13 pages, 8 figure
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