Preoperative CT versus diffusion weighted magnetic resonance imaging of the liver in patients with rectal cancer:a prospective randomized trial

Introduction. Colorectal cancer is one of the most frequent cancers in the world and liver metastases are seen in up to 19% of patients with colorectal cancers. Detection of liver metastases is not only vital for sufficient treatment and survival, but also for a better estimation of prognosis. The aim of this study was to evaluate the feasibility of diffusion weighted MRI of the liver as part of a combined MR evaluation of patients with rectal cancers and compare it with the standard preoperative evaluation of the liver with CT.Methods. Consecutive patients diagnosed with rectal cancers were asked to participate in the study. Preoperative CT and diffusion weighted MR (DWMR) were compared to contrast enhanced laparoscopic ultrasound (CELUS).Results. A total of 35 patients were included, 15 patients in Group-1 having the standard CT evaluation of the liver and 20 patients in Group-2 having the standard CT evaluation of the liver and DWMR of the liver. Compared with CELUS, the per-patient sensitivity/specificity was 50/100% for CT, and for DWMR: 100/94% and 100/100% for Reader 1 and 2, respectively. The per-lesion sensitivity of CT and DWMR were 17% and 89%, respectively compared with CELUS. Furthermore, one patient had non-resectable metastases after DWMR despite being diagnosed with resectable metastases after CT. Another patient was diagnosed with multiple liver metastases during CELUS, despite a negative CT-scan.Discussion. DWMR is feasible for preoperative evaluation of liver metastases. The current standard preoperative evaluation with CT-scan results in disadvantages like missed metastases and futile operations. We recommend that patients with rectal cancer, who are scheduled for MR of the rectum, should have a DWMR of the liver performed at the same time

Nordic homicide in deep time : lethal violence in the early modern era and present times

Nordic Homicide in Deep Time draws a unique, detailed picture of developments in human violence and presents new findings on homicide in Northern Europe in two eras – the 17th century and early 21st century. The book provides answers to questions, such as where and when did homicide typically occur, who were the victims and the offenders, and what were the circumstances of their conflicts? Additionally, it offers an empirically grounded view on how state consolidation and changing routines of everyday life transformed the patterns of criminal homicide in the Nordics. This publication is also a methodological experiment. When developing a new approach for extending homicide research into the deep past, the authors created a new instrument, the Historical Homicide Monitor. This tool combines wide explanatory scope, measurement standardization, and articulated theory expression. By retroactively expanding research data to the pre-statistical era, the method enables long-duration comparison of different periods and areas. Written by an interdisciplinary team of criminologists and historians for professionals, students and anyone interested in the history of human behaviour, Nordic Homicide in Deep Time helps the reader to understand modern homicide by revealing the historical continuities and changes in lethal violence.VertaisarvioitupeerReviewe

Nordic Homicide in Deep Time

Nordic Homicide in Deep Time draws a unique and detailed picture of developments in human interpersonal violence and presents new findings on rates, patterns, and long-term changes in lethal violence in the Nordics. Conducted by an interdisciplinary team of criminologists and historians, the book analyses homicide and lethal violence in northern Europe in two eras – the 17th century and early 21st century. Similar and continuous societal structures, cultural patterns, and legal cultures allow for long-term and comparative homicide research in the Nordic context. Reflecting human universals and stable motives, such as revenge, jealousy, honour, and material conflicts, homicide as a form of human behaviour enables long-duration comparison. By describing the rates and patterns of homicide during these two eras, the authors unveil continuity and change in human violence. Where and when did homicide typically take place? Who were the victims and the offenders, what where the circumstances of their conflicts? Was intimate partner homicide more prevalent in the early modern period than in present times? How long a time elapsed from violence to death? Were homicides often committed in the context of other crime? The book offers answers to these questions among others, comparing regions and eras. We gain a unique and empirically grounded view on how state consolidation and changing routines of everyday life transformed the patterns of criminal homicide in Nordic society. The path to pacification was anything but easy, punctuated by shorter crises of social turmoil, and high violence. The book is also a methodological experiment that seeks to assess the feasibility of long-duration standardized homicide analysis and to better understand the logic of homicide variation across space and over time. In developing a new approach for extending homicide research into the deep past, the authors have created the Historical Homicide Monitor. The new instrument combines wide explanatory scope, measurement standardization, and articulated theory expression. By retroactively expanding research data to the pre-statistical era, the method enables long-duration comparison of different periods and areas. Based on in-depth source critique, the approach captures patterns of criminal behaviour, beyond the control activity of the courts. The authors foresee the application of their approach in even remoter periods. Nordic Homicide in Deep Time helps the reader to understand modern homicide by revealing the historical continuities and changes in lethal violence. The book is written for professionals, university students and anyone interested in the history of human behaviour

Can we evidence-base injury prevention and management in women's football? A scoping review.

This review aimed, as part of a larger FIFA project aiming to steer women's football research, to scope literature on any level of competitive football for women, to understand the current quantity of research on women's football injuries. The study reviewed all injury-related papers scoped by a recent scoping review mapping all published women's football research with an updated search performed on 23 February 2021. Eligibility criteria assessment followed the recent scoping review with injury-specific research focus. A total of 497 studies were scoped. Most studies contained an epidemiological (N = 226; 45%) or risk factors assessment (N = 105; 21%). Less assessed areas included financial burden (N = 1; <1%) and injury awareness (N = 5; 1%). 159 studies (32%) assessed injuries of the whole body. The most common single location assessed in the literature was the knee (N = 134, 27%), followed by head/face (N =108, 22%). These numbers were, however, substantially lowered, when subdivided by playing level and age-group. The volume of research focuses especially on descriptive research and specific body locations (head/face and knee). Although information can be taken from studies in other sports, more football-specific studies to support management and prevention of injuries are warranted

Nordic homicide report : Homicide in Denmark, Finland, Iceland, Norway and Sweden, 2007–2016

This report compares the trends and patterns of lethal violence in from 2007 to 2016, in five Nordic countries: Denmark, Finland, Iceland, Norway and Sweden. The report is a product of the “Nordic Homicide from Past to Present” research project, funded by the Scandinavian Research Council for criminology. The main findings include: * Based on homicide mortality rates, the Nordic countries form currently three groups: compared to the rates in Denmark and Sweden, the homicide mortality rate is about 30 per cent higher in Finland and 30 per cent lower in Norway and Iceland. However, by global standards, all the countries have extremely low rates of homicide mortality. * In Denmark, Iceland, Norway, and Sweden, the hotspots of lethal violence are the metropolitan areas of the largest cities; in Finland, the rural areas and small towns in the eastern and northern provinces. In this respect, the situation in Scandinavia and Iceland resembles that in Western Europe, in Finland again, it resembles that in some of the eastern European countries. * In all five countries, non-working working-age male substance abusers are hugely over-represented among homicide offenders and victims. * In the three Scandinavian countries, immigrants make up to 25 to 40 per cent of homicide offenders, while in Iceland and Finland their proportion is about 10 per cent. While this difference reflects the sizes of the immigrant populations, differential risks are also involved. In all Nordic countries, the homicide offending rates of immigrants are higher than those of native residents, but this difference is substantially larger in Scandinavia than in Iceland or Finland. * The role of alcohol and drinking situations in lethal violence is central in Finland, Iceland and Sweden, but only moderate in Denmark and insignificant in Norway. This is reflected in the temporal distribution of homicide incidents; and to the lower percentage of crimes in near relations and the higher percentage of male victims in Finland, Iceland and Sweden. * Concerning firearm homicides, Sweden is currently a clear outlier in the region with every fourth homicide being perpetrated by firearms. The firearm homicide rate in Sweden is the highest of all the Nordic countries. The situation has deteriorated fast in the last few years. Firearm homicides are concentrated in the metropolitan areas of Stockholm, Gothenburg and Malmö and to a large extent are linked to gang violence in a few residential districts. * Nordic homicide clearance rates are among the highest in the world; offenders are caught and sentenced almost without exception. The official control policies are effective and arguably contribute to very low homicide rates in the region when compared with the global situation

An Updated Systematic Review of Turnout Position Assessment Protocols Used in Dance Medicine and Science Research.

Turnout, or external rotation of the lower limbs, is an integral part of classical ballet technique. Contributions of lower limb structures to turnout can be separated into HER (hip external rotation) and NHCTO (non-hip contributions to turnout). This study aimed to review systematically methods used to measure turnout in dance medicine and science research, thereby updating the literature since the Champion and Chatfield review of 2008. CINAHL, EMBASE, PubMed, and Web of Science were searched in January 2018 by two independent reviewers. Peer-reviewed studies measuring turnout in dance were included, except those published prior to March 23, 2006, as that was the last date of publication included in the previous review. Abstracts, theses, and editorials were excluded. From each study, study design, population (sample size, sex, age, genre of dance, and level of training), details of the protocol used, and result of turnout measurement were extracted, as well as reliability data. All included studies were assessed for risk of bias, using either Newcastle-Ottawa scale, AXIS tool, or PEDro scale as appropriate for each study design. A total of 41 studies met the inclusion criteria. Twenty-eight studies measured HER, nine measured NCHTO, and 22 measured total turnout (TTO). An increased number of studies investigated TTO (N = 22; N = 4 passive TTO) and NHCTO (N = 9) since 2006. All studies scored above half the points attainable from their respective tools. Results suggest HER remains the most common protocol for measuring turnout (N = 28), despite the fact it disregards input from structures below the hip. It is concluded that researchers should focus on quality of reporting of protocols to ensure repeatability and facilitate comparison of results. Future studies should include absolute reliability and validity testing of all currently used protocols so that standardization can be fully achieved

Education and adolescent cognitive ability as predictors of dementia in a cohort of Danish men.

BackgroundAn association between education and dementia is well-established but it is unclear whether education is associated with dementia after accounting for early life cognitive ability and whether there is a joint effect, such that the risk associated with one of the exposures depends on the value of the other. We examined separate and joint associations of adolescent cognitive ability and educational attainment with risk of dementia among Danish men born between 1939 and 1959.MethodsMen (N = 477,421) from the Danish Conscription Database were followed for dementia from the age 60 for up to 17 years via patient and prescription registry linkages. Exposure measures included cognitive ability assessed at the conscript board examination around age 18 and highest educational level (low: 0-10 year, medium: 10-13 years, high: ≥13 years) at age 30 from registry records. Associations with dementia diagnosis were estimated in Cox proportional hazards models adjusted for birth year and age at conscript board examination. Interaction was assessed on the multiplicative scale by including a product term between the two exposure measures and on the additive scale by calculating relative excess risk due to interaction (RERI) between different levels of the exposure measures.ResultsCompared to men in the high education group hazard ratio [HR] for men in the medium and low group were 1.21 (95% confidence interval [CI]: 1.13, 1.30) and 1.34 (95% CI: 1.24, 1.45), respectively when not adjusting for cognitive ability. Additional adjustment for cognitive ability attenuated the magnitude of the associations, but they remained significant (education medium: HR = 1.10, 95% CI: 1.02, 1.19 and education low: HR = 1.12, 95% CI: 1.02, 1.22). A 10% higher cognitive ability score was associated with a 3.8% lower hazard of dementia (HR = 0.962; 95% CI: 0.957, 0.967), and the magnitude of the association only changed marginally after adjustment for education. Men in the low education group with relatively low cognitive ability were identified as a high-risk subgroup for dementia. The increased risk associated with exposure to both risk factors did, however, not significantly depart from the sum of risk experienced by men only exposed to one of the risk factors (estimates of RERI were not significantly different from 0) and no significant evidence of either additive or multiplicative interactions was found.ConclusionsIn conclusion, the results suggest that education and cognitive ability protect against the risk of dementia independently of one another and that increases in educational attainment may at least partially offset dementia risk due to low cognitive ability

Can we evidence-base injury prevention and management in women's football? A scoping review.

This review aimed, as part of a larger FIFA project aiming to steer women's football research, to scope literature on any level of competitive football for women, to understand the current quantity of research on women's football injuries. The study reviewed all injury-related papers scoped by a recent scoping review mapping all published women's football research with an updated search performed on 23 February 2021. Eligibility criteria assessment followed the recent scoping review with injury-specific research focus. A total of 497 studies were scoped. Most studies contained an epidemiological (N = 226; 45%) or risk factors assessment (N = 105; 21%). Less assessed areas included financial burden (N = 1; <1%) and injury awareness (N = 5; 1%). 159 studies (32%) assessed injuries of the whole body. The most common single location assessed in the literature was the knee (N = 134, 27%), followed by head/face (N =108, 22%). These numbers were, however, substantially lowered, when subdivided by playing level and age-group. The volume of research focuses especially on descriptive research and specific body locations (head/face and knee). Although information can be taken from studies in other sports, more football-specific studies to support management and prevention of injuries are warranted