A Comparative study of oxidant and Anti-oxidant parameters in Chronic Renal Failure, Haemodialysis (Pre &Post) and Controls

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Aim of our study is comparison of oxidant and anti oxidant parameters in chronic renal failure, Hemodialysis (pre and post) and control subjects. Materials and Methods: The present study was conducted on a patient group comprising of 50 patients diagnosed with CRF, 50 were pre hemodialysis, 50 were post hemodialysis (MHD). This patient group was compared to a healthy group including 100 controls. All the study participants were admitted in the department of Medicine [Nephrology department] at “Fathima Institute of Medical Sciences”, Kadapa. Andhra Pradesh. India. The obtained serum samples were used for biochemical analysis for estimating MDA, vitamin A and Glutathione Peroxidase (GPx). Conclusion: Our results reflects the primary mechanisms of oxidative stress and inflammation during hemodialysis which may cause of CVD development in hemodialysed patients

To study the organization of LDL-C/HDL-C ratio and inflammatory marker CRP in acute myocardial infarction

There is an increasing incidence of coronary artery disease in India. We therefore need a tool to evaluate the severity and prognosis of this acute myocardial infarction. In acute myocardial infarction, the function of plaque rupture and inflammation has already been identified. Aim: To study the organization of LDL-C/HDL-C ratio and inflammatory marker CRP in acute myocardial infarction. Methods and Material: Patients who have been diagnosed as acute myocardial infarction (ST Elevation Acute myocardial Infarction or Unstable angina/Non ST Elevation Myocardial Infarction) and admitted to ICCU of Rajiv Gandhi institute of Medical Sciences, Kadapa, AP. are the subjects. Sample consists of 100 cases of acute myocardial infarction. Case history was taken from the patients, and studied according to proforma. Conclusion: Elevated levels of CRP are independent indicators of adverse effects. When contrast with the LDL / HDL ratio, CRP is used for risk stratification and as a prognostic predictor. These findings suggest that in patients with acute myocardial infarction, raised CRP Levels is significant as compared to LDL/HDL ratio

Neuroinflammation in Alzheimer's disease: An understanding of physiology and pathology

Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex etiology. Neuroinflammation has been found to be an underlying cause of the disease, although it demonstrates significant defensive role and renders the brain immunologically secured. This review focuses on the physiology and pathology of this crucial biological process and the diverse factors involved in and acting in a concerted manner to play a pivotal role either in the physiology or pathology of the disease. We used Pubmed, Pubmed Central, and Medline databases for a period of 3 months. It also summarizes the recent advances in neuroinflammation in both in vitro and in vivo. This review eventually warrants further studies on animal models of AD to unravel the complete pathophysiology of the disease and also accentuates the burgeoning need to protect astrocytes which can become a substantial therapeutic avenue

To analyze how LDL-C/HDL-C ratio and inflammatory marker CRP are organized in acute myocardial infarction

There is an increasing incidence of coronary artery disease in India. We therefore need a tool to evaluate the severity and prognosis of this acute myocardial infarction. In acute myocardial infarction, the function of plaque rupture and inflammation has already been identified. Aim: To study the organization of LDL-C/HDL-C ratio and inflammatory marker CRP in acute myocardial infarction. Methods and Material: Patients  who  have  been  diagnosed  as  acute  myocardial  infarction (ST Elevation  Acute  myocardial  Infarction  or  Unstable  angina/Non  ST  Elevation Myocardial Infarction) and admitted to ICCU of Government of medical sciences, Kadapa, AP. July 2021 to December 2021, are the subjects. Sample consists of 100 cases of acute myocardial infarction. Case history was taken from the patients, and studied according to proforma. Conclusion: Elevated levels of CRP are independent indicators of adverse effects. When contrast with the LDL / HDL ratio, CRP is used for risk stratification and as a prognostic predictor. These findings suggest that in patients with acute myocardial infarction, raised CRP Levels is significant as compared to LDL/HDL ratio

A comparative study of oxidant and anti-oxidant parameters in chronic renal failure, haemodialysis (pre & post) and controls

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Aim of our study is comparison of oxidant and anti oxidant parameters in chronic renal failure, Hemodialysis (pre and post) and control subjects. Materials and Methods: The present study was conducted on a patient group comprising of 50 patients diagnosed with CRF, 50 were pre hemodialysis, 50 were post hemodialysis (MHD). This patient group was compared to a healthy group including 100 controls. All the study participants were admitted in the department of Medicine [Nephrology department] at “Rajiv Gandhi Institute Of Medical Sciences”, Kadapa. Andhra Pradesh. India. Study Period : July 2020 to December 2020 ,The obtained serum samples were used for biochemical analysis for estimating MDA, vitamin A and Glutathione Peroxidase (GPx).&nbsp