L-Asparaginase and antioxidant activity of endophytic bacteria associated with ethnomedicinal plants

59-64The present investigation was aimed at assessing production of L-asparaginase by endophytic bacteria, associated with ethnomedicinal plants of North-east India, keeping in view their relevance as anticancer agents. In recent years, microbial asparaginases have drawn particular interest because of their potential antineoplastic properties and significant application in food industries. Among the endophytes, Serratia marcescens cenA, Bacillus subtilis cenB, B. methylotrophicus PotA <span style="mso-fareast-language:EN-IN; mso-bidi-font-style:italic" lang="EN-GB">and B. siamensis C53 produced significant level of L-asparaginase. Their enzyme activity was determined at different incubation periods and the maximum L-asparaginase activity was noted in the culture filtrate of endophytic S. marcescens cenA (0.8579 IU.mL-1), followed by B. methylotrophicus PotA (0.8379 IU.mL-1) at 96 h. The study also revealed that endophytic bacteria had good antioxidant properties, with S. marcescens cenA showing the highest activity (<span style="mso-fareast-font-family: AdvEPSTIM;mso-ansi-language:EN-US" lang="EN-US">IC50=17±0.013 mg.mL-1). </span

A Facile, Efficient and Green Protocol for the Synthesis of 1-(2-hydroxyethyl)- 3-alkyl/aryl/aralkyl/hydroxyethyl-5- oxo-octahydroquinazolines and 3,3′- (alkanediyl)bis(1-(2-hydroxyethyl)-5- oxo-octahydroquinazolines) A Facile, Efficient and Green Protoco

Abstract A facile microwave assisted one-pot synthesis of novel 1-(2-hydroxyethyl)-3-alkyl/aryl/aralkyl/hydroxyethyl-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazolines 3a-h and 3,3&apos;-(alkanediyl) bis (1-(2-hydroxyethyl)-5-oxo-1,2,3,4,5,6,7,8-octahydroquinazolines) 4a-d has been devised by the cyclocondensation of cyclic enaminones 2a-b with primary amines/diamines and formaldehyde. The structures of the products have been established by spectral and analytical data. The present paper describes a one-pot, efficient, clean, simple, fast and environment friendly strategy for the synthesis of hitherto unknown octahydroquinazolines and bis-octahydroquinazolines from easily accessible starting materials in good yields with promising biological properties. The methodology reported herein is an example of multi-component reactions (MCRs)

Reaction of Selenium Dioxide with Aromatic Ketones in the Presence of Boron Triflouride Etherate: A Protocol for the Synthesis of Triarylethanones

An efficient regioselective protocol for the C–C bond formation by the unexpected α,α-diarylation of aromatic ketones with unactivated arenes in the presence of selenium dioxide and boron trifluoride etherate has been developed. The generality and functional tolerance of this protocol is demonstrated by the synthesis of a series of triarylethanones

Reaction of Selenium Dioxide with Aromatic Ketones in the Presence of Boron Triflouride Etherate: A Protocol for the Synthesis of Triarylethanones

An efficient regioselective protocol for the C–C bond formation by the unexpected α,α-diarylation of aromatic ketones with unactivated arenes in the presence of selenium dioxide and boron trifluoride etherate has been developed. The generality and functional tolerance of this protocol is demonstrated by the synthesis of a series of triarylethanones