La vitamina D durante la gestación

Objetivo: describir la relevancia del déficit de vitamina D durante la gestación, así como sus consecuencias y sus factores de riesgo, y evaluar la necesidad de administración de suplementos para su tratamiento. Metodología: revisión bibliográfica de las bases de datos Turning Research Into Practice, Evidence-Based Nursing, Joanna Briggs Institute, Biblioteca Cochrane Plus, guías de la National Institute of Health and Care Excellence, PubMed, Índice Médico Español (IME), Cumulative Index to Nursing and Allied Health Literature (CINAHL), en inglés y español, y de la disponibilidad en la biblioteca desde la cual se hacía la consulta. La última búsqueda se efectuó en diciembre de 2017. Resultados: se obtuvo un total de 127 referencias bibliográficas, de las que 30 cumplían los criterios de selección. Se seleccionaron 26 artículos: 15 artículos originales, 5 revisiones bibliográficas y 6 guías de práctica clínica y protocolos de actuación. Conclusiones: la vitamina D es fundamental en todas las etapas de la vida de la mujer. El déficit de vitamina D en las gestantes es un hecho constatado en los estudios internacionales actuales. Se describe la necesidad de optimizar los niveles de vitamina D durante la gestación, dado que su déficit está relacionado con complicaciones importantes que pueden afectar tanto a la madre como al recién nacido, e incluso a la vida futura de ambos. No obstante, la necesidad, la seguridad y la eficacia de los suplementos de vitamina D administrados de manera sistemática y preventiva durante el embarazo es un tema no exento de controversia entre los profesionales, dado su potencial efecto tóxico. No se dispone de estudios que demuestren el beneficio de los suplementos de vitamina D a corto y largo plazo. Cabe destacar que no parecen tener un efecto teratogénico ni ser potencialmente nocivos para la gestante

Strange hadron collectivity in pPb and PbPb collisions

ARXIV EPRINT: 2205.00080 (https://arxiv.org/abs/2205.00080).Copyright © 2023 CERN, for the benefit of the CMS Collaboration. The collective behavior of $${\textrm{K}}_{\textrm{S}}^0$$ K S 0 and $$\Lambda /\overline{\Lambda}$$ Λ / Λ ¯ strange hadrons is studied by measuring the elliptic azimuthal anisotropy (v2) using the scalar-product and multiparticle correlation methods. Proton-lead (pPb) collisions at a nucleon-nucleon center-of-mass energy $$\sqrt{s_{\textrm{NN}}}$$ s NN = 8.16 TeV and lead-lead (PbPb) collisions at $$\sqrt{s_{\textrm{NN}}}$$ s NN = 5.02 TeV collected by the CMS experiment at the LHC are investigated. Nonflow effects in the pPb collisions are studied by using a subevent cumulant analysis and by excluding events where a jet with transverse momentum greater than 20 GeV is present. The strange hadron v2 values extracted in pPb collisions via the four- and six-particle correlation method are found to be nearly identical, suggesting the collective behavior. Comparisons of the pPb and PbPb results for both strange hadrons and charged particles illustrate how event-by-event flow fluctuations depend on the system size.SCOAP

Industry-oriented software-based system for quality evaluation of vehicle audio environments

Abstract—A new set of integrated software tools are proposed for the evaluation of vehicle audio quality for industrial purposes, taking advantage of the auralization approach that allows to simulate the binaural listening experience outside the cockpit. Two main cooperating tools are implemented. The first fulfills the function of acquiring relevant data for system modeling and for canceling the undesired effects of the acquisition chain. The second offers a user-friendly interface for real-time simulation of different car audio systems and the consequent evaluation of both objective and subjective performances. In the latter case, the listening procedure is directly experienced at the PC workplace, leading to a significant simplification of the audio-quality assessing task for comparing the selected systems. Moreover, such kind of subjective evaluation allowed to validate the proposed approach through a complete set of experiments (developed by means of a dedicated software environment) based on appropriate ITU recommendations

Circulating esRAGE is Associated with a Pro-Inflammatory/Pro-Atherothrombotic Profile in Familial Combined Hyperlipidemia Patients with Non-alcoholic Fatty Liver Disease

Circulating esRAGE is Associated with a Pro-Inflammatory/Pro-Atherothrombotic Profile in FCHL patients with NAFLD in patients with traits of metabolic syndrom

Chronic mitral regurgitation: left atrial deformation analysis by two-dimensional speckle tracking echocardiography.

Abstract BACKGROUND: Speckle tracking echocardiography (STE) is a novel method for the angle-independent and objective quantification of myocardial deformation; it has recently evolved, enabling the quantification of longitudinal myocardial left atrial (LA) deformation dynamics. To investigate the effects of chronic mitral regurgitation (MR) on these functional atrial indices, we analyzed LA function by STE in a group of asymptomatic patients with chronic degenerative MR. METHODS: The study population included 36 patients with mild MR, 38 with moderate MR, and 42 with severe MR. 52 age-matched controls were also recruited. Global peak atrial longitudinal strain (global PALS) was measured in all subjects by averaging all atrial segments. RESULTS: Age, gender, and LV ejection fraction in all pathological groups were comparable to those in the controls. Global PALS was higher in the mild MR group (46.7 ± 9.1%) in comparison with the controls (40.5 ± 6.2%; P < 0.001); instead global PALS was lower in the moderate MR group (25.7 ± 7.1%) and further reduced in the severe MR group (13.2 ± 5.2%) in comparison with the controls (40.5 ± 6.2%; overall P < 0.0001 by ANOVA, P < 0.05 for all pairwise comparisons). In multivariate analysis, E/Em ratio emerged as the principal independent determinant of global PALS. CONCLUSIONS: Our study provides new insight for the LA function analysis in response to different degrees of MR, showing that STE measurements of LA longitudinal strain may be considered a promising tool for the early detection of impairment of LA compliance in patients with asymptomatic chronic MR