Loss of life risk due to impacts of boulders on vehicles traveling along a very busy road.

The paper is aimed to describe the used approach for calculating the risk along a road stretch belonging to a very busy coastal road in Southern Italy. During the time span 1969-2013, 22 rockfalls affecting this road were inventoried. On 18th February 2014 a new rockfall happened and several boulders reached the northern lane of the road. On the basis of collected data concerning the landslide hazard and road vulnerability, a procedure for the probability evaluation of a fatal accident - for a road user - is presented, discussed in details and compared. The analysis is meant to allow the design of appropriate protection devices along the cliffs overhanging the road

Measurements of critical current diffraction patterns in annular Josephson junctions

We report systematic measurements of the critical current versus magnetic field patterns of annular Josephson junctions in a wide magnetic field range. A modulation of the envelope of the pattern, which depends on the junction width, is observed. The data are compared with theory and good agreement is found.Comment: 4 pages, 5 figure

Comparison between qualitative rockfall risk rating systems for a road affected by high traffic intensity

Abstract. The paper deals with the assessment of the rockfall risk for a road stretch, in southern Italy, affected by high traffic intensity. Three qualitative rockfall risk rating systems (QRSs) which use an exponential scoring with a base of 3 were employed, and then the results were compared. The used methods are the following: the Rockfall Hazard Rating System, a modified version of this method already proposed in the past by one of the authors, and the modified version of the Colorado Rockfall Hazard Rating System. The studied road stretch is about 11 km in length and is part of a very tortuous road flanked by rock slopes characterised by complex geostructural and geomechanical layouts. The road was subdivided into 56 sections, defined so as to have – as much as possible – homogeneous geological characteristics. By means of the three QRSs, it was possible to ascertain that high levels of rockfall risks are due to the lack of ditches, a very limited percentage of decision sight distance (PDSD) values and a small roadway width, whereas a subordinate factor is the hazard caused by rockfalls. Several positive and negative aspects arising from the use of the employed methods are highlighted and discussed.</p

A Class of N-O-Type Oxidants to Access High-Valent Palladium Species

This article presents a new class of mild reagents that is capable of oxidizing palladacycle(II) complexes to high-valent palladium species, promoting the formation of C–N bonds in stoichiometric and catalytic conditions. The weak N–O bond and the extremely electron with-drawing benzenesulfonate group on the oxygen atom of the oxidant are crucial moieties to ensure the desired activity. The oxidation mech-anism could involve outer-sphere single electron transfer (SET) processes, opening the possibility for a complementary reactivity of Pd(IV) species.Royal Society H2020 European Research Counci

Current distribution in a parallel configuration superconducting strip-line detector

Superconducting detectors based on parallel microscopic strip-lines are promising candidates for single molecule detection in time-of-flight mass spectrometry. The device physics of this configuration is complex. In this letter, we employ nano-optical techniques to study the variation of current density, count rate, and pulse amplitude transversely across the parallel strip device. Using the phenomenological London theory, we are able to correlate our results to a non-uniform current distribution between the strips, governed by the London magnetic penetration depth. This fresh perspective convincingly explains anomalous behaviour in large area parallel superconducting strip-line detectors reported in previous studies

A WZW model based on a non-semi-simple group

We present a conformal field theory which desribes a homogeneous four dimensional Lorentz-signature space-time. The model is an ungauged WZW model based on a central extension of the Poincar\'e algebra. The central charge of this theory is exactly four, just like four dimensional Minkowski space. The model can be interpreted as a four dimensional monochromatic plane wave. As there are three commuting isometries, other interesting geometries are expected to emerge via $O(3,3)$ duality.Comment: 8 pages, phyzzx, IASSNS-HEP-93/61 Texable versio

Form factor expansion of the row and diagonal correlation functions of the two dimensional Ising model

We derive and prove exponential and form factor expansions of the row correlation function and the diagonal correlation function of the two dimensional Ising model

Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure

Aldosterone is a mineralocorticoid hormone synthesized by the adrenal glands that has several regulatory functions to help the body maintain normal volume status and electrolyte balance. Studies have shown significantly higher levels of aldosterone secretion in patients with congestive heart failure compared with normal patients. Elevated levels of aldosterone have been shown to elevate blood pressure, cause left ventricular hypertrophy, and promote cardiac fibrosis. An appreciation of the true role of aldosterone in patients with chronic heart failure did not become apparent until the publication of the Randomized Aldactone Evaluation Study. Until recently, the use of aldosterone receptor antagonists has been limited to patients with severe heart failure and patients with heart failure following myocardial infarction. The Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF) study added additional evidence to support the expanded use of aldosterone receptor antagonists in heart failure patients. The results of the EMPHASIS-HF trial showed that patients with mild-to-moderate (New York Heart Association Class II) heart failure had reductions in mortality and hospitalizations from the addition of eplerenone to optimal medical therapy. Evidence remains elusive about the exact mechanism by which aldosterone receptor antagonists improve heart failure morbidity and mortality. The benefits of aldosterone receptor antagonist use in heart failure must be weighed against the potential risk of complications, ie, hyperkalemia and, in the case of spironolactone, possible endocrine abnormalities, in particular gynecomastia. With appropriate monitoring, these risks can be minimized. We now have evidence that patients with mild-to-severe symptoms associated with systolic heart failure will benefit from the addition of an aldosterone receptor antagonist to the standard therapies of angiotensin-converting enzyme inhibitors and beta-blockers. This review will address the pharmacologic basis of aldosterone receptor antagonists in patients with heart failure and the clinical impact of this therapy