25 research outputs found
Brain Metastases in Soft Tissue Sarcomas: Case Report and Literature Review
Background and purpose: Brain metastasis is a relatively uncommon event in the natural history of soft tissue sarcomas.
The increasing use of chemotherapy may have caused a reduction in local relapses as well as distant failures leading to an
improvement in survival, thereby allowing metachronous seeding of the brain, a sanctuary site. The purpose of this report is
to increase awareness amongst clinicians regarding such a possibility
Desmoplastic small round cell tumor: Extra abdominal and abdominal presentations and the results of treatment
BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare
malignant neoplasm of adolescent males. Current multimodality treatment
prolongs life and rarely achieves cure. Aim : To review the presenting
features, histopathology and outcome of 18 patients with DSRCT treated
at a single institution. Setting and Design : This is a retrospective
observational study of patients with DSRCT who presented at the Tata
Memorial Hospital between January 1994 to January 2005. Materials and
Methods: Eighteen patients of DSRCT seen during this period were
evaluated for their clinical presentation, response to chemotherapy and
other multimodality treatment and overall survival. The cohort of 18
patients included 11 males (61%) and 7 females (39%) with a mean age of
16 years (Range 1\ubd - 30 years). Majority (83%) presented with
abdomino-pelvic disease. The others, involving chest wall and
extremities. There were 6 patients (33%) with metastatic disease at
presentation. Results: The treatment primarily included a
multimodality approach using a combination of multiagent chemotherapy
with adjuvant surgery and radiotherapy as applicable. A response rate
of 39% (CR-1, PR-6), with chemotherapy was observed. The overall
response rate after multimodality treatment was 39% (CR-5, PR-2). The
overall survival was poor except in patients who had complete excision
of the tumor. Conclusion: Abdomino-pelvic site was the commonest
presentation, the disease can occur at other non-serosal surfaces also.
Despite aggressive treatment the outcome was poor. However, complete
surgical excision seems to provide a better survival
Desmoplastic small round cell tumor: Extra abdominal and abdominal presentations and the results of treatment
BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare
malignant neoplasm of adolescent males. Current multimodality treatment
prolongs life and rarely achieves cure. Aim : To review the presenting
features, histopathology and outcome of 18 patients with DSRCT treated
at a single institution. Setting and Design : This is a retrospective
observational study of patients with DSRCT who presented at the Tata
Memorial Hospital between January 1994 to January 2005. Materials and
Methods: Eighteen patients of DSRCT seen during this period were
evaluated for their clinical presentation, response to chemotherapy and
other multimodality treatment and overall survival. The cohort of 18
patients included 11 males (61%) and 7 females (39%) with a mean age of
16 years (Range 1½ - 30 years). Majority (83%) presented with
abdomino-pelvic disease. The others, involving chest wall and
extremities. There were 6 patients (33%) with metastatic disease at
presentation. Results: The treatment primarily included a
multimodality approach using a combination of multiagent chemotherapy
with adjuvant surgery and radiotherapy as applicable. A response rate
of 39% (CR-1, PR-6), with chemotherapy was observed. The overall
response rate after multimodality treatment was 39% (CR-5, PR-2). The
overall survival was poor except in patients who had complete excision
of the tumor. Conclusion: Abdomino-pelvic site was the commonest
presentation, the disease can occur at other non-serosal surfaces also.
Despite aggressive treatment the outcome was poor. However, complete
surgical excision seems to provide a better survival
Global survey of the roles, satisfaction, and barriers of home healthcare nurses on the provision of palliative care
Background: the World Health Assembly urges members to build palliative care (PC) capacity as an ethical imperative. Nurses provide PC services in a variety of settings, including the home and may be the only health care professional able to access some disparate populations. Identifying current nursing services, resources, and satisfaction and barriers to nursing practice are essential to build global PC capacity. Objective: to globally examine home health care nurses' practice, satisfaction, and barriers, regarding existing palliative home care provision. Design: needs assessment survey. Setting/Subjects: five hundred thirty-two home health care nurses in 29 countries. Measurements: a needs assessment, developed through literature review and cognitive interviewing. Results: nurses from developing countries performed more duties compared with those from high-income countries, suggesting a lack of resources in developing countries. Significant barriers to providing home care exist: personnel shortages, lack of funding and policies, poor access to end-of-life or hospice services, and decreased community awareness of services provided. Respondents identified lack of time, funding, and coverages as primary educational barriers. In-person local meetings and online courses were suggested as strategies to promote learning. Conclusions: it is imperative that home health care nurses have adequate resources to build PC capacity globally, which is so desperately needed. Nurses must be up to date on current evidence and practice within an evidence-based PC framework. Health care policy to increase necessary resources and the development of a multifaceted intervention to facilitate education about PC is indicated to build global capacity
From donation to self-reflection: living of volunteers of a toy library for children with cancer
Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline
Abstract
Although pain is one of the most prevalent and bothersome symptoms children with cancer
experience, evidence-based guidance regarding assessment and management is lacking. With
44 international, multidisciplinary healthcare professionals and nine patient representatives, we
aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological, and physical management of tumor-, treatment-, and procedure-related pain in children with cancer. In this paper, we present our thorough methodology for this development, including the challenges we faced and how we approached these. This
lays the foundation for our clinical practice guideline, for which there is a high clinical demand