Anticonvulsant activity of hydroalcoholic phoenix dactylifera fruit extract and pimpinella anisum oil in mice

Epilepsy is a group of long-term neurological disorders characterized by epileptic seizures. The present study sought to investigate the anticonvulsant and neuroprotective Activity of Hydroalcoholic Phoenix dactylifera fruit extract (HAPD) and Pimpinella Anisum Oil (PAO) against Pentylenetetrazole (PTZ) and Maximal Electric Shock (MES) induced a seizure in mice. Mice groups were treated with HAPD1000 mg/kg, PAO 4 ml/kg. The onset of a seizure and generalized seizure were measured, followed by Gamma-Aminobutyric Acid (GABA) and antioxidant enzymes assessments. The potential of these substances to induce any neurological toxicity was also evaluated by using rotarod, forced swim test and horizontal screen test. The current study demonstrates that HAPD and PAO delay onset of the seizure and generalized seizure, also elevated GABA and antioxidant enzymes level and haven’t any neurological toxicity. The current study suggests that hydroalcoholic Phoenix dactylifera extract and Pimpinella anisum oil have anticonvulsant, neuroprotective and antioxidant activity and can increase brain GABA level

Incorporating the effect of weather in construction scheduling and management with sine wave curves: application in the United Kingdom

The impact of (adverse) weather is a common cause of delays, legal claims and economic losses in construction projects. Research has recently been carried out aimed at incorporating the effect of weather in project planning; but these studies have focussed on either a narrow set of weather variables, or a very limited range of construction activities or projects. A method for processing a country’s historical weather data into a set of weather delay maps for some representative standard construction activities is proposed. Namely, sine curves are used to associate daily combinations of weather variables to delay and provide coefficients for expected productivity losses. A complete case study comprising the construction of these maps and the associated sine waves for the UK is presented along with an example of their use in building construction planning. Findings of this study indicate that UK weather extends project durations by an average of 21%. However, using climatological data derived from weather observations when planning could lead to average reductions in project durations of 16%, with proportional reductions in indirect and overhead costs

Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?

<p>Abstract</p> <p>Background</p> <p>In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer.</p> <p>Case report</p> <p>A 45-year-old premenopausal woman was incidentally found to have an abdominal mass, 3 years after removal of a cutaneous melanoma lesion. Ultrasound and CT scan revealed left two solid masses, which were found to be an ovarian tumor at laparotomy. Left oophorectomy was performed. Histopathology and immunohistochemistry showed melanoma metastasis to the ovary. Nine months later, the patient developed epilepsy and confusion. Magnetic Resonance Imaging showed unique Wright frontal lobe lesion. She underwent stereotactic radio surgery and dacarbazine monotherapy. For months later, the patient is died from disseminate disease progression.</p> <p>Conclusion</p> <p>Ovarian metastasis is an unusual presentation of cutaneous melanoma and the prognosis was dismal. As illustrated by this case report, a differential diagnosis of a metastatic malignant melanoma must be considered.</p

A grey wolf optimization-based method for segmentation and evaluation of scaling in reinforced concrete bridges

202303 bcwwAccepted ManuscriptSelf-fundedPublishe

An exponential chaotic differential evolution algorithm for optimizing bridge maintenance plans

202201 bcrcNot applicableSelf-fundedPublished24 month

دور المرأة الريفية فى تنمية نظم انتاج البروتين الحيواني بمحافظة الشرقية

Protein, in particular of animal source, Is one of the most important components of the diet. Although, the average per capita animal protein intake in Egypt is still less than far from that recommended by international organizations, due to the reluctance of local production growth to keep pace with consumer needs. There are many obstacles that face filling the deficit of local production by importation. Among these obstacles, the spread of epidemic diseases such as mad-cow and foot and mouth disease and avian influenza in livestock populations of potential exporting markets to Egypt. The importance of this study is the lack of research on the role of rural women in livestock enterprising operations, particularly, in dairy enterprises. This study used a sample survey data of from Sharkia Governorate's villages. The analysis of the structure of the farm income from livestock holding on farm shows that whereas, the gross margin per feddan was around L.E. 3618 on farms operated by men, it jumped to L.E. 4172 on those farms operated by women. The monetary income per feddan went up at to its maximum by dairy sales. This value reaches around L.E. 2888, representing 46% in the case of farms run by men. In the case of farms managed by women amounted to L.E. 4038 from dairy sales, representing 76% of the total costs. Purchased feed costs calculated per feddan, in the case of farms run by men, amounted to a maximum costs item of L.E. 1008, representing 37.33% of the total costs. Such costs item decreased to L.E. 430 per feddan on farms managed by women, representing 42.34% of cash operating costs. Therefore, net farm income in farms managed by women amounted to L.E. 3453 which surpassed the farms operated by men, that .reached L.E. 2391, but after deducting imputed costs of farm household labor and owned capital invested, such profit declined much due to family labor. Therefore, the study recommends to focus upon supporting the dairy enterprise on small traditional farms in rural Egypt. The farms operated by women should get the priority, to empower the women towards generating reasonable income to sponsor their households. Such support may include soft loans at low interest rate with facilities in repayment schedule. It includes also training course in animal husbandry and farm management. Veterinary care services should be accessible to these target groups at minimum costs. Such proposed socio-economic programs overcome the social obstacle that prevents rural women from working outside their farms and/or villages to earn livings for their household, particularly when the female-headed household is only a rural woman

Discussion of "incorporating practicability into genetic algorithm-based time-cost optimization" by Bryan Christopher Que

10.1061/(ASCE)0733-9364(2002)128:2(139)Journal of Construction Engineering and Management1296706-708JCEM