Increased risk of gastric cancer in the CC genotype -31C/G polymorphism in Survivin gene promoter

Background and Objective: Gastric cancer is the most common cancers worldwide. The survivin gene which encodes an apoptosis protein inhibitor plays an important role in maintenance and integrity of the gastric mucosa. The gene is necessary for the normal physiologic function of the stomach, but its expression increases in gastric cancer. Regarding with the role of polymorphisms of the promoter region in genes expression, this study was done to determine the association of single- nucleotide polymorphism (rs9904341) -31C/G in promoter survivin gene with risk of gastric cancers. Methods: In this case-control study, 101 patients with gastric cancer and 101 matched age and gender healthy subjects as the control were examined by PCR-RFLP technique. Results: Genotype CC was significantly increased the risk of gastric cancer up to 2.4 folds (95% CI=1.03–5.61, P<0.04) and allele C, as risk allele, significantly increased the risk of gastric cancer up to 1.5 folds (95% CI=1.02–2.30, P<0.03). Also, CC + GC genotypes significantly increased the risk of diffuse type of gastric cancer by 4.4-fold (95% CI=1.30-15.10, OR=4.4, P<0.01). Conclusion: This study showed that single- nucleotide polymorphism (rs9904341) -31C/G in promoter survivin gene significantly increase the risk of gastric cancers

Group social work intervention enhances the sexual satisfaction of women with Multiple Sclerosis: a randomized controlled trial study

Sexual problems are among the most common disorders that people with Multiple Sclerosis have to deal with, resulting in decreased sexual satisfaction and quality of life. The study is aimed to investigate the impact of group social work intervention on the sexual satisfaction of women with Multiple Sclerosis. The methodology was a randomized controlled trial and 58 participants recruited (30 for control group and 28 for intervention group). The intervention was based on group social work with an empowerment approach within eight sessions. The average age of the participants was 35.95 ± 6.41 most of whom had high school diploma (62.1). The findings indicate that, in terms of sexual satisfaction (t = 5.47, Sig = 0.03, df = 56), primary disorders (t = 2.42, Sig = 0.019, df = 56), and tertiary disorders (t = 3.77, Sig = 0.002, df = 56), there is a significant difference between intervention and control groups. © 2020, © 2020 Taylor & Francis

The emotional impact of the COVID-19 pandemic on individuals with progressive multiple sclerosis

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