Recommender-based enhancement of discovery in Geoportals

Abstract In many cases web search engines like Google are still used for discovery of geographic base information. This can be explained by the fact that existing approaches for Geo-information retrieval still face significant challenges. Discovery in currently available Geoportals is usually restricted to text-based search based on keywords, title and abstract as well as applying spatial and temporal filters. Furthermore, user context as well as search results of other users are not incorporated. In order to improve the quality of search results we propose to extend the suitable searching matches in Geoportals with user behaviour and to present them as non-directly linked recommendations like in e.g. Amazon's "Customers Who Bought This Item Also Bought" approach. As shown in the proof-of-concept EU FP7 EnerGEO Geoportal, it guarantees results that are not in the data itself but rather derived from the context of other users' searches and views

Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer

Abstract Objective: We evaluate the number of surgical two-stage procedures after FSA during breast-conserving therapy (clinical false negative result of FSA) and investigate the influence of microcalcifications, small tumour diameter, neoadjuvant therapy and preoperative biopsy on the clinical false negative rate of FSA. Subjects: We retrospectively examined 1016 patients after intraoperative FSA during breast-conserving therapy for breast cancer operated between 1995 and 2001 at the Medical University Vienna. Results: Only 9% of all patients had to undergo a two-stage operation due to a false negative intraoperative FSA result. The annual local recurrence rate was 1.2% in all patients with no difference between one-and two-stage operated patients. In situ and pT1 lesions were similarly distributed between one-stage and two-stage operated patients. The use of neoadjuvant therapy and stereotactic biopsy (reflecting non-palpable lesions and microcalcifications) were significantly predictive for a false negative FSA result. The use of a preoperative core biopsy, however, reduced the necessity of performing a two-stage operation. Conclusion: Our study demonstrates that FSA leads to a low rate of two-stage operations. Small lesions and microcalcifications as well as the occurrence of intraductal cancer cells and neoadjuvant therapy increased while preoperative core biopsy reduced the false negative rate of FSA. Overall local recurrence rates after FSA were acceptable

Cross-Domain Building Models-A Step towards Interoperability

Buildings have a multifunctional character, which makes it hard to define just one model for all their diverse functions. As these diverse functions are addressed by actors of different perspectives and domain backgrounds, the possibility to exchange available building information would be desirable. Two main models for the creation of building information are Industry Foundation Classes/Building Information Modelling (IFC/BIM) and City Geography Markup Language (CityGML). As the importance of information interchange has been recognized, several authors have tried to develop intermediate models for the information exchange between IFC/BIM and CityGML, e.g., the Unified Building Model (UBM), the BIM Oriented Indoor data Model (BO-IDM), the Indoor Emergency Spatial Model (IESM) and the BIM-GIS integration model for Flood Damage Assessment (FDA model). Nevertheless, all these models have been created with a certain use in mind. Our focus in this article is to identify common elements amongst these proposed models and to combine them into one “core model” that is as simple as possible, while simultaneously containing all important elements. Furthermore, this base model extracted from proposed intermediate models can then be expanded to serve specific use requirements, while still being exchangeable. To show this cross-domain character of the core model, we validated the resulting model with two cases of use (production environment/maintenance and 3D digital cadaster)

The multigene signature MammaPrint impacts on multidisciplinary team decisions in ER+, HER2- early breast cancer

Background: Validated multigene signatures (MGS) provide additional prognostic information when evaluating clinical features of ER+, HER2- early breast cancer. We have studied the quantitative and qualitative impact of MGS on multidisciplinary team (MDT) recommendations. Methods: We prospectively recruited 75 ER+, HER2- breast cancer patients. Inclusion was based on biopsy assessment of grade, hormone receptor status, HER2, clinical tumour and nodal status. A fresh tissue sample was sent for MammaPrint (MP), TargetPrint analysis at surgery. Clinical risk was decided by the MDT in the absence of MP results and repeated following the collection of MP results. Decision changes were recorded and a health technology assessment was undertaken to compare cost effectiveness. Results: The majority of patients were assigned low to intermediate clinical risk by the MDT. According to MP, 76% were low risk. A very high correlation between local IHC and the TargetPrint assessment was shown. In over a third of patients, discordance between clinical and molecular risk was observed. Decision changes were recorded in half of these cases (18.6%) and resulted in two out of three patients not requiring chemotherapy. The use of MP was also found to be more cost effective. Conclusions: The multigene signature MP revealed clinical and molecular risk discordance in a third of patients. The impact of this on MDT recommendations was most profound in cases where few clinical risk factors were observed and enabled some women to forgo chemotherapy. The use of MGS is unlikely to have an impact in either clinically low-risk women or in patients with more than one relative indication for chemotherapy