3,492 research outputs found
Synthesis and CâC Coupling Reactivity of a Dinuclear Ni^IâNi^I Complex Supported by a Terphenyl Diphosphine
Mono- and bimetallic complexes of nickel supported by a terphenyl diphosphine have been synthesized. The reported complexes show diverse metalâarene interactions in the solid state. Reactions of an o,oâ˛-biphenyldiyl dinickel complex with CO and dichloroalkanes lead to fluorene derivatives, indicating the formation of carbonâcarbon bonds at a bimetallic moiety
Modular Orthopaedic Tissue Engineering With Implantable Microcarriers and Canine Adipose-Derived Mesenchymal Stromal Cells
Mesenchymal stromal cells (MSC) hold significant potential for tissue engineering applications. Modular tissue engineering involves the use of cellularized âbuilding blocksâ that can be assembled via a bottom-up approach into larger tissue-like constructs. This approach emulates more closely the complexity associated hierarchical tissues compared with conventional top-down tissue engineering strategies. The current study describes the combination of biodegradable porous poly(DL-lactide-co-glycolide) (PLGA) TIPS microcarriers with canine adipose-derived MSC (cAdMSC) for use as implantable conformable building blocks in modular tissue engineering applications. Optimal conditions were identified for the attachment and proliferation of cAdMSC on the surface of the microcarriers. Culture of the cellularized microcarriers for 21 days in transwell insert plates under conditions used to induce either chondrogenic or osteogenic differentiation resulted in self-assembly of solid 3D tissue constructs. The tissue constructs exhibited phenotypic characteristics indicative of successful osteogenic or chondrogenic differentiation, as well as viscoelastic mechanical properties. This strategy paves the way to create in situ tissue engineered constructs via modular tissue engineering for therapeutic applications
Hadrons in the Nuclear Medium
Quantum Chromodynamics, the microscopic theory of strong interactions, has
not yet been applied to the calculation of nuclear wave functions. However, it
certainly provokes a number of specific questions and suggests the existence of
novel phenomena in nuclear physics which are not part of the the traditional
framework of the meson-nucleon description of nuclei. Many of these phenomena
are related to high nuclear densities and the role of color in nucleonic
interactions. Quantum fluctuations in the spatial separation between nucleons
may lead to local high density configurations of cold nuclear matter in nuclei,
up to four times larger than typical nuclear densities. We argue here that
experiments utilizing the higher energies available upon completion of the
Jefferson Laboratory energy upgrade will be able to probe the quark-gluon
structure of such high density configurations and therefore elucidate the
fundamental nature of nuclear matter. We review three key experimental
programs: quasi-elastic electro-disintegration of light nuclei, deep inelastic
scattering from nuclei at , and the measurement of tagged structure
functions. These interrelated programs are all aimed at the exploration of the
quark structure of high density nuclear configurations.
The study of the QCD dynamics of elementary hard processes is another
important research direction and nuclei provide a unique avenue to explore
these dynamics. We argue that the use of nuclear targets and large values of
momentum transfer at would allow us to determine whether the physics of the
nucleon form factors is dominated by spatially small configurations of three
quarks.Comment: 52 pages IOP style LaTex file and 20 eps figure
A Titanium Nitride Absorber for Controlling Optical Crosstalk in Horn-Coupled Aluminum LEKID Arrays for Millimeter Wavelengths
We discuss the design and measured performance of a titanium nitride (TiN)
mesh absorber we are developing for controlling optical crosstalk in
horn-coupled lumped-element kinetic inductance detector arrays for
millimeter-wavelengths. This absorber was added to the fused silica
anti-reflection coating attached to previously-characterized, 20-element
prototype arrays of LEKIDs fabricated from thin-film aluminum on silicon
substrates. To test the TiN crosstalk absorber, we compared the measured
response and noise properties of LEKID arrays with and without the TiN mesh.
For this test, the LEKIDs were illuminated with an adjustable, incoherent
electronic millimeter-wave source. Our measurements show that the optical
crosstalk in the LEKID array with the TiN absorber is reduced by 66\% on
average, so the approach is effective and a viable candidate for future
kilo-pixel arrays.Comment: 7 pages, 5 figures, accepted for publication in the Journal of Low
Temperature Physic
Horn-Coupled, Commercially-Fabricated Aluminum Lumped-Element Kinetic Inductance Detectors for Millimeter Wavelengths
We discuss the design, fabrication, and testing of prototype horn-coupled,
lumped-element kinetic inductance detectors (LEKIDs) designed for cosmic
microwave background (CMB) studies. The LEKIDs are made from a thin aluminum
film deposited on a silicon wafer and patterned using standard
photolithographic techniques at STAR Cryoelectronics, a commercial device
foundry. We fabricated twenty-element arrays, optimized for a spectral band
centered on 150 GHz, to test the sensitivity and yield of the devices as well
as the multiplexing scheme. We characterized the detectors in two
configurations. First, the detectors were tested in a dark environment with the
horn apertures covered, and second, the horn apertures were pointed towards a
beam-filling cryogenic blackbody load. These tests show that the multiplexing
scheme is robust and scalable, the yield across multiple LEKID arrays is 91%,
and the noise-equivalent temperatures (NET) for a 4 K optical load are in the
range 26\thinspace\pm6 \thinspace \mu \mbox{K} \sqrt{\mbox{s}}
Triple oxygen isotopic composition of the high-<sup>3</sup>He/<sup>4</sup>He mantle
Measurements of Xe isotope ratios in ocean island basalts (OIB) suggest that Earthâs mantle accreted heterogeneously, and that compositional remnants of accretion are sampled by modern, high-3He/4He OIB associated with the Icelandic and Samoan plumes. If so, the high-3He/4He source may also have a distinct oxygen isotopic composition from the rest of the mantle. Here, we test if the major elements of the high-3He/4He source preserve any evidence of heterogeneous accretion using measurements of three oxygen isotopes on olivine from a variety of high-3He/4He OIB locations. To high precision, the Î17O value of high-3He/4He olivines from Hawaii, Pitcairn, Baffin Island and Samoa, are indistinguishable from bulk mantle olivine (Î17OBulk Mantle â Î17OHigh 3He/4He olivine = â0.002 Âą 0.004 (2 Ă SEM)â°). Thus, there is no resolvable oxygen isotope evidence for heterogeneous accretion in the high-3He/4He source. Modelling of mixing processes indicates that if an early-forming, oxygen-isotope distinct mantle did exist, either the anomaly was extremely small, or the anomaly was homogenised away by later mantle convection.
The δ18O values of olivine with the highest 3He/4He ratios from a variety of OIB locations have a relatively uniform composition (âź5â°). This composition is intermediate to values associated with the depleted MORB mantle and the average mantle. Similarly, δ18O values of olivine from high-3He/4He OIB correlate with radiogenic isotope ratios of He, Sr, and Nd. Combined, this suggests that magmatic oxygen is sourced from the same mantle as other, more incompatible elements and that the intermediate δ18O value is a feature of the high-3He/4He mantle source. The processes responsible for the δ18O signature of high-3He/4He mantle are not certain, but δ18Oâ87Sr/86Sr correlations indicate that it may be connected to a predominance of a HIMU-like (high U/Pb) component or other moderate δ18O components recycled into the high-3He/4He source
Microwave Kinetic Inductance Detector (MKID) Camera Testing for Submillimeter Astronomy
Developing kilopixel focal planes for incoherent submm- and mm-wave detectors remains challenging due to either the large hardware overhead or the complexity of multiplexing standard detectors. Microwave kinetic inductance detectors (MKIDs) provide a efficient means to produce fully lithographic background-limited kilopixel focal planes. We are constructing an MKID-based camera for the Caltech Submillimeter Observatory with 576 spatial pixels each simultaneously sensitive in 4 bands at 230, 300, 350, and 400 GHz. The novelty of MKIDs has required us to develop new techniques for detector characterization. We have measured quasiparticle lifetimes and resonator Qs for detector bath temperatures between 200 mK and 400 mK. Equivalent lifetime measurements were made by coupling energy into the resonators either optically or by driving the third harmonic of the resonator. To determine optical loading, we use both lifetime and internal Q measurements, which range between 15,000 and 30,000 for our resonators. Spectral bandpass measurements confirm the placement of the 230 and 350 GHz bands. Additionally, beam maps measurements conform to expectations. The same device design has been characterized on both sapphire and silicon substrates, and for different detector geometries. We also report on the incorporation of new shielding to reduce detector sensitivity to local magnetic fields
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