17 research outputs found
Powering Sustainable Moon Exploration: Energy strategies for interoperability and cooperation
Get PDFTowards a Lunar Exploration Technology Adaptive Roadmap: Contributions from SGAC’s Technical Unit Research for a Thriving Lunar Ecosystem
Get PDFTrajectory tracking of a quadrotor with unknown parameters and its fault-tolerant control via sliding mode fault observer
No full textFatal Outcome of Ilheus Virus in the Cerebrospinal Fluid of a Patient Diagnosed with Encephalitis
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Influence of previous Zika virus infection on acute dengue episode.
No full textBackgroundThe co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection.Methodology/principal findingsWe enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue.Conclusions/significanceOur findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection
Distribution of dengue-confirmed cases in São José do Rio Preto, São Paulo State, during 2019 epidemic, according to months and epidemiological weeks.
No full textDistribution of dengue-confirmed cases in São José do Rio Preto, São Paulo State, during 2019 epidemic, according to months and epidemiological weeks.</p
Measure of differential diagnostic performance for DENV NS1 protein, ZIKV NS1 protein, and for peptides DV-15, DV-20, and ZV-54.
No full textMeasure of differential diagnostic performance for DENV NS1 protein, ZIKV NS1 protein, and for peptides DV-15, DV-20, and ZV-54.</p
Screening of reactive peptides using monoclonal antibodies.
No full text(A) Heatmap matrix of peptides assessed with monoclonal specific antibodies against ZIKV or DENV in an indirect IgG ELISA platform. Highest scores were selected for soluble synthesis. Peptide ZV-53 was not stable in soluble form and excluded from analysis. (B) IgG pepELISA for validation of soluble peptides. Serum samples from patients validated with PRNT were evaluated on plates with DV-15, DV-20, ZV-54, and ZV-107.</p
