Emotional dysregulation, temperament and lifetime suicidal ideation among youths with mood disorders

Background: Psychopathological dimensions contributing to suicidal ideation in young age are poorly understood. We aimed to investigate the involvement of emotional dysregulation and temperament in suicide risk in a sample of accurately selected young patients with mood disorders and a matched sample of healthy controls (HC). Methods: We assessed 50 young patients (aged 14–25 years) with DSM-5 bipolar or depressive disorders for clinical and psychopathological characteristics and 82 age and sex, educational level, and smoking habits-matched HC. Emotional dysregulation and temperament were assessed using the Difficulties in Emotion Regulation Scale (DERS) and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A-39), respectively. We tested their associations with suicidal ideation, using standard univariate/bivariate methods, preceded by overall multivariate analysis. Results: In the group of patients, 24 (48%) reported lifetime suicide ideation (LSI). Patients with LSI scored higher on emotional dysregulation (p < 0.001) and cyclothymic (p < 0.001), irritable (p = 0.01), and hyperthymic temperaments (p = 0.003) than HC. Patients with LSI specifically presented with more emotional dysregulation (p < 0.001) and cyclothymic temperament (p = 0.001), than patients without LSI (N = 26). Conclusions: Tempera-mental features, in particular cyclothymic temperament, and emotion dysregulation may represent independent factors for increased vulnerability to lifetime suicidal ideation in young adults with mood disorders

Synthesis of furylpyrimidinones and evaluation of their cytostatic and antiviral activity

Condensation between furyllithium reagents and pyrimidinones 1, 2, 3, and 4 has been studied. The product composition is strongly dependent upon the reaction conditions and purification methodologies. Cytostatic and antiviral activities of some substrates and reaction products is reporte

SYNTHESIS AND MOLECULAR MODELING OF TAXANES MODIFIED AT RING-C

Some new paclitaxel analogs, modified at ring C, - namely the 7-alpha-mesylate, 7-deoxy-7-alpha-amino, 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-Delta(6,7)-20-O-seco and 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-6,7-epoxy-20-O-seco derivatives -are presented. The biological activity of 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-Delta(6,7)-20-O-seco, 4-deacetoxy-4 alpha-hydroxy-4 beta-hydroxymethyl-5 alpha-acetoxy-6,7-epoxy-20-O-seco, 7-deoxy-7-alpha-azido, 7-deoxy-7-alpha-amino and 6,7-epoxy derivatives have been evaluated A molecular modeling study on some paclitaxel derivatives has been done in an attempt to rationalize the difference in biological activity