2,347 research outputs found
A methodology to allow avalanche forecasting on an information retrieval system
This paper presents adaptations and tests undertaken to allow an information retrieval (IR) system to forecast the likelihood of avalanches on a particular day. The forecasting process uses historical data of the weather and avalanche conditions for a large number of days. A method for adapting these data into a form usable by a text-based IR system is first described, followed by tests showing the resulting system’s accuracy to be equal to existing ‘custom built’ forecasting systems. From this, it is concluded that the adaptation methodology is effective at allowing such data to be used in a text-based IR system. A number of advantages in using an IR system for avalanche forecasting are also presented
Influence of Structural Flexibility on Flapping Wing Propulsion
The inelastic deformation behavior of PMR-15 neat resin, a high-temperature thermoset polymer, was investigated at 288 degrees C. The experimental program was designed to explore the influence of strain rate on tensile loading, unloading, and strain recovery behaviors. In addition, the effect of the prior strain rate on the relaxation response of the material, as well as on the creep behavior following strain controlled loading were examined. The experimental data were modeled with the Viscoplasticity Based on Overstress (VBO) theory. A systematic procedure for determining model parameters was developed and the model was employed to predict the response of the material under various test histories. Additionally the effects of prior aging at 288 degrees C in argon on the time (rate)-dependent behavior of the PMR-15 polymer were evaluated in a series of strain and load controlled experiments. Based on experimental results, the VBO theory was extended to capture the environmentally induced changes in the material response. Several of the VBO material parameters were expanded as functions of prior aging time. The resulting model was used to predict the high-temperature behavior of the PMR-15 polymer subjected to prior aging of various durations
The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
THE ROLE OF THE SPARC ACIDIC DOMAIN AND EGF-LIKE MODULE IN GLIOMA MIGRATION, INVASION, AND SIGNALING
HEATHER M. MCCLUNG
Advisor: Sandra A. Rempel, Ph.D.
Major: Pharmacology
Degree: Doctor of Philosophy
We have previously shown that Secreted Protein Acidic and Rich in Cysteine (SPARC) is upregulated in all astrocytoma grades and increases tumor cell migration and invasion. It is thought that different domains within the protein may regulate SPARC functions, suggesting domain-specific targeting to inhibit invasion. To enhance our understanding of SPARC-mediated invasion, we first confirm, at the protein level, our previous cDNA array results, that SPARC increases expression of the matrix metalloproteases (MMPs) MT1-MMP and MMP-2. We also demonstrate that SPARC increases MMP-2 activation and the secretion and processing of galectin-3, a known target of MMPs. To investigate the roles of specific domains, we used a SPARC-GFP fusion protein and deletion mutant constructs of SPARC-GFP with deletions of either the Acidic Domain or EGF-like Module. We confirm our previous findings that SPARC-GFP increases migration and activation of p38 MAPK and HSP27 signaling compared to GFP control cells. Deletion of the Acidic Domain increases cell adhesion and reduces SPARC-induced migration and p38 MAPK/HSP27 signaling. The EGF-like Module Deletion mutant decreases SPARC-induces migration and dramatically decreases the expression and phosphorylation of HSP27. The extent to which the deletions reduce migration was dependent upon the presence of extracellular matrix. Preliminary data also suggest that the deletions affect invasion and MMP-2 activation. In conclusion, both regions of interest regulate SPARC-induced migration and signaling though the p38 MAPK/HSP27 signaling pathway. Importantly, their impact on migration is influenced by the presence or absence of extracellular matrix. This and future studies of the deletion mutants will provide valuable insight into new strategies that effectively target invasion in SPARC-expressing tumors
An apparatus for in-situ direct shear tests on snow
The article presents a prototype of a new device for measuring the shear strength of snow specimens in situ. The resistance to sliding of a snow slab on a mountain slope is a key parameter in snow mechanics. The proposed apparatus acts as a sampler, to obtain a nearly undisturbed specimen, and as a shear box, similar to those used in the laboratory, with complete control of the test procedure. The main components of the device are a pneumatic system, for the application of normal and shear forces to the specimen, a real-time controller for commanding and recording of the data, and a computer. The apparatus can be carried to the place of the experiments and operated by a team of two researchers. Calibration and preliminary tests are also described in the article
Statistical avalanche zoning.
Runout for the extreme event on an avalanche path is calculated from confidence limits on a regression analysis of path topographic parameters. This results in redefinition of the traditional zoning problem by dividing it into an estimation of runout distance by an engineering decision on the choice of confidence limit to the estimate and a dynamic problem with boundary conditions defined by the chosen limit
Cellular-Automata model for dense-snow avalanches
This paper introduces a three-dimensional model for simulating dense-snow avalanches, based on the numerical method of cellular automata. This method allows one to study the complex behavior of the avalanche by dividing it into small elements, whose interaction is described by simple laws, obtaining a reduction of the computational power needed to perform a three-dimensional simulation. Similar models by several authors have been used to model rock avalanches, mud and lava flows, and debris avalanches. A peculiar aspect of avalanche dynamics, i.e., the mechanisms of erosion of the snowpack and deposition of material from the avalanche is taken into account in the model. The capability of the proposed approach has been illustrated by modeling three documented avalanches that occurred in Susa Valley (Western Italian Alps). Despite the qualitative observations used for calibration, the proposed method is able to reproduce the correct three-dimensional avalanche path, using a digital terrain model, and the order of magnitude of the avalanche deposit volume
Clocked Atom Delivery to a Photonic Crystal Waveguide
Experiments and numerical simulations are described that develop quantitative
understanding of atomic motion near the surfaces of nanoscopic photonic crystal
waveguides (PCWs). Ultracold atoms are delivered from a moving optical lattice
into the PCW. Synchronous with the moving lattice, transmission spectra for a
guided-mode probe field are recorded as functions of lattice transport time and
frequency detuning of the probe beam. By way of measurements such as these, we
have been able to validate quantitatively our numerical simulations, which are
based upon detailed understanding of atomic trajectories that pass around and
through nanoscopic regions of the PCW under the influence of optical and
surface forces. The resolution for mapping atomic motion is roughly 50 nm in
space and 100 ns in time. By introducing auxiliary guided mode (GM) fields that
provide spatially varying AC-Stark shifts, we have, to some degree, begun to
control atomic trajectories, such as to enhance the flux into to the central
vacuum gap of the PCW at predetermined times and with known AC-Stark shifts.
Applications of these capabilities include enabling high fractional filling of
optical trap sites within PCWs, calibration of optical fields within PCWs, and
utilization of the time-dependent, optically dense atomic medium for novel
nonlinear optical experiments
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