210 research outputs found
CHARACTERISTICS OF AUTOIMMUNE INFLAMMATION IN THE PATIENTS WITH LUNG TUBERCULOSIS
Tuberculosis is a granulomatous disease caused by Mycobacterium tuberculosis, being characterized by the development of caseous granulomas in various organs, mainly in lungs. M. tuberculosis is known to be a trigger for autoimmune inflammation, due to the possible mimicry of bacterial proteins as autoantigens. Recently, a significance of mesenchymal vimentin as an autoantigen in mycobacterial infections has been actively discussed. The aim of the present study was to determine autoantibodies for various vimentin modifications in the patients with tuberculosis.The study was performed in 2014-2017 and included 28 patients with pulmonary tuberculosis (group I), 30 patients with nonspecific lung diseases (group II): 15 with granulomatous polyangiitis, and 15 with different alveolites. Control group consisted of healthy subjects (n = 40). Concentration of antibodies to mutated citrullinated vimentin (anti-MCV) was measured using ELISA (ORGENTEC, Germany). The patients with elevated anti-MCV levels were tested for antibodies to cyclic citrullinated peptide (anti-CCP) using ELISA technique (EUROIMMUN, Germany). Statistical analysis was carried out using GraphPad Prism 6 (GraphPad Software, USA), Statistica 10 (Statsoft, USA) using nonparametric analysis of samples with Mann-Whitney and Chi-square criteria, and Spearman method for correlation analysis. The differences were considered statistically significant at p < 0.05.The anti-MCV concentrations were significantly higher in patients with tuberculosis (group I, 60.7% of cases, 17/28) than in group II, and control group (23.6 and 25.0% of cases, respectively). No statistically significant differences were revealed between the results of anti-MVC and anti-CCP levels in comparison group with the control group (p = 0.18).High levels of anti-MCV antibodies in the patients with pulmonary tuberculosis reflect an opportunity of developing autoimmune process in the disease pathogenesis. Measurement of plasma anti-MCV antibody concentrations may be important for correction of the therapy, especially upon administration of immunosuppressive and hormonal corticosteroid drugs. It has been shown that anti-CCP are not characteristic to the lung diseases
DNA footprints of European hedgehogs, Erinaceus europaeus and E. concolor: Pleistocene refugia, postglacial expansion and colonization routes
XANDAR: Exploiting the X-by-Construction Paradigm in Model-based Development of Safety-critical Systems
XANDAR: Exploiting the X-by-Construction Paradigm in Model-based Development of Safety-critical Systems
Regulasi Emosi Mahasiswa Mantan Pecandu Narkoba
Artikel Ini Mendeskripsikan Cara Mahasiswa Mempertahankan Regulasi Emosi Dalam Menghadapi Kecanduan Narkoba. Untuk Mengetahui Tingkat Regulasi Emosi Dilakukan Penelitian Pendekatan Kualitatif Dengan Metode Studi Kasus Terhadap Perilaku Mahasiswa Yang Pernah Mengalami Kecanduan Narkoba. Penelitian Dilakukan Selama 1 Bulan Melalui Pengamatan Perilaku Mahasiswa Tersebut Sejauh Mana Kemampuannya Dalam Mempertahankan Regulasi Emosinya. Pengumpulan Data Dilakukan Melalui Teknik Observasi Dan Wawancara. Hasil Penelitian Menunjukkan Bahwa Cara Mahasiswa Pecandu Narkoba Meregulasi Emosinya Adalah Memonitor Emosi, Memodifikasi Emosi Dan Mengevaluasi Emos
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