Majorana neutrino versus Dirac neutrino in e+e−→W+W−{\rm e}^{+}{\rm e}^{-} \to {\rm W}^{+}{\rm W}^{-} through radiative corrections

Radiative corrections to ${\rm e}^{+}{\rm e}^{-}\! \rightarrow {\rm W}^{+}{\rm W}^{-}$ from Majorana neutrinos are studied in the context of the see-saw mechanism. Focusing on the effects of the fourth generation neutrinos, we calculate W-pair form factors, the differential cross sections and the forward-backward asymmetries for the polarized electrons at one-loop level. The behaviour of the form factors at the threshold of Majorana particle pair productions is found to differ from that of Dirac particle pair productions. In the cross section for unpolarized electrons, the radiative corrections, depending on the mass parameters of the see-saw mechanism, are found to be $\sim 0.5\%$ at the energy range of the LEP200 and the next generation linear colliders.Comment: 10 pages, Latex, 4 figures(no included, available on request

Research on the Prolonged Effect of Physical Education Class on University Students: Effect Verification of the Intervention Program

Abstract The purpose of this study was to verify the prolonged effect of the intervention program on university students in physical education class. Subjects were 211 university students who participated in physical education class. The intervention group is comprised of 81 students (40 males, 41 females), and the control group is comprised of 128 students (80 males, 48 females). All data were obtained through questionnaires. The questionnaires consisted of personal characteristics, skills relating to bachelor's degree ability (communication skill, teamwork skill, problem-solving skill, leadership skill), and exercise behavior (the stage of exercise behavior change, self-efficacy for exercise, decisional balance). The questionnaire data were obtained "at the beginning of the semester (pre)", "at the end of the semester (post)", and "two years after the end of the semester (the two-year follow-up)". Communication program and behavior change skills were applied to the intervention group. The main finding was that the stage of exercise behavior changed in the intervention group. Comparing "pre" with "post", the ratio of students with improved stage was 51.8%; the ratio of students who maintained their stage was 37.3%; and the ratio of students whose stage worsened was 10.8%. Additionally, comparing "post" with "the two-year follow-up", the ratio of students with improved stage was 19.3%; the ratio of students who maintained their stage was 43.4%; and the ratio of students whose stage worsened was 37.3%. The results of twoway repeated measures ANOVA (group-time) showed that there were significant interactions for S. Nakayama et al. 248 "perceived benefits of exercise (Pros)", "decoding skill", "properly transmitted skill", "teamwork skill", and "leadership skill". The results of one-way repeated measures ANOVA showed that "properly transmitted skill", "teamwork skill", and "leadership skill" significantly increased on account of the intervention program post and at the two-year follow-up. These results indicate that the intervention program on university students, which consists of a communication program and behavior change skills, was partly effective for improving skills relating to bachelor's degree ability two years after the end of semester

Comparison and characterization of α-amylase inducers in Aspergillus nidulans based on nuclear localization of AmyR

AmyR, a fungal transcriptional activator responsible for induction of amylolytic genes in Aspergillus nidulans, localizes to the nucleus in response to the physiological inducer isomaltose. Maltose, kojibiose, and d-glucose were also found to trigger the nuclear localization of GFP-AmyR. Isomaltose- and kojibiose-triggered nuclear localization was not inhibited by the glucosidase inhibitor, castanospermine, while maltose-triggered localization was inhibited. Thus, maltose itself does not appear to be an direct inducer, but its degraded or transglycosylated product does. Non-metabolizable d-glucose analogues were also able to trigger the nuclear localization, implying that these sugars, except maltose, directly function as the inducers of AmyR nuclear entry. The inducing activity of d-glucose was 4 orders-of-magnitude weaker compared with isomaltose. Although d-glucose has the ability to induce α-amylase production, this activity would generally be masked by CreA-dependent carbon catabolite repression. Significant induction of α-amylase by d-glucose was observed in creA-defective A. nidulans

Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C-reactive protein in type 2 diabetic and nondiabetic subjects: the Hoorn Study.

Background: Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade inflammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively. Secondly we investigated whether the presence of type 2 diabetes modifies these associations. Materials and Methods: Six hundred and ten subjects of a general population of middle-aged and elderly subjects, 170 of whom had type 2 diabetes, participated in this cross-sectional study. Linear regression analyses were used to study whether tHcy was associated with vWf, sVCAM-1 and CRP, and whether the presence of diabetes modified these associations. Results: After adjustment for confounders, tHcy was significantly but weakly associated with vWf (β=0·15, P=0·05) and sVCAM-1 (β=0·082, P=0·04). tHcy was not significantly associated with CRP (β=0·02, P=0·91). The presence of diabetes did not significantly modify these associations. Conclusions: This study provides evidence that tHcy is, at most, weakly associated with endothelial dysfunction as estimated from plasma vWf, and with leukocyte adhesion as estimated from plasma sVCAM-1. tHcy was not significantly associated with chronic low-grade inflammation as estimated from plasma CRP. Our data thus suggest that the link between tHcy and atherothrombosis cannot be explained by associations of tHcy with vWf, sVCAM-1 or CRP

Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report

BACKGROUND: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. CASE PRESENTATION: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma- or osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. CONCLUSION: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components

A study of home deaths in Japan from 1951 to 2002

BACKGROUND: Several surveys in Japan have indicated that most terminally ill Japanese patients would prefer to die at home or in a homelike setting. However, there is a great disparity between this stated preference and the reality, since most Japanese die in hospital. We report here national changes in home deaths in Japan over the last 5 decades. Using prefecture data, we also examined the factors in the medical service associated with home death in Japan. METHODS: Published data on place of death was obtained from the vital statistics compiled by the Ministry of Health, Labor and Welfare of Japan. We analyzed trends of home deaths from 1951 to 2002, and describe the changes in the proportion of home deaths by region, sex, age, and cause of death. Joinpoint regression analysis was used for trend analysis. Logistic regression analysis was performed to identify secular trends in home deaths, and the impact of age, sex, year of deaths and cause of deaths on home death. We also examined the association between home death and medical service factors by multiple regression analysis, using home death rate by prefectures in 2002 as a dependent variable. RESULTS: A significant decrease in the percentage of patients dying at home was observed in the results of joinpoint regression analysis. Older patients and males were more likely to die at home. Patients who died from cancer were less likely to die at home. The results of multiple regression analysis indicated that home death was related to the number of beds in hospital, ratio of daily occupied beds in general hospital, the number of families in which the elderly were living alone, and dwelling rooms. CONCLUSION: The pattern of the place of death has not only been determined by social and demographic characteristics of the decedent, but also associated with the medical service in the community