Effect of yogic practices on selected physiological variables among hypertensive middle-aged women

The purpose of the random group experimental study was to investigate the effect of Yogic Practices on selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) among Hypertensive middle aged women. It was hypothesized that there would be a significant difference due to Yogic Practices on selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) among Hypertensive middle-aged women than the control group. Random group experimental design was used. The random sampling design was followed to select the subjects. To achieve the purpose of the study, 30 women between the age 45 and 55 years were selected randomly from Chennai and they were divided into two groups such as Yogic Practices (Group A) and Control Group (Group B). Each group consists of 15 subjects. The pre-test was taken for the two Groups on the selected dependent variables before the start of the training program. Group A was undergoing Yogic Practices for 12weeks, 6 days a week, One-hour maximum daily and Group B (Control Group) was permitted to undergo their normal lifestyle (active rest) during the course of the experiment. After the experimental period of 12 weeks, Post-tests were conducted for the two groups on selected dependent variables. The selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) were measured through Lab test. Analysis of Co-Variance (ANCOVA) was used to find out the significant difference between experimental group and the Control Group. The test of significance was fixed at 0.05 level of confidence. It was concluded that Yogic Practices improved Physiological variables among Hypertensive middle-aged women than the Control Group. Hence, the hypothesis was accepted at 0.05 level of confidence

Effect of lutein on lipid profile in hypercholesterolemic rats

Background: Hyperlipidemia or Dyslipidemia is the major cause of atherosclerosis1 and associated conditions. Low levels of high-density-lipoprotein cholesterol (HDL-C) are the major causes of increased atherogenic risk 1. Aggressive cholesterol reduction in patients with atherosclerotic disease is now the standard of care2. In addition to life style modification, patients with risk factors need lipid lowering drug therapy. The drugs available now do not reduce LDL oxidation, and oxidative stress associated with hyperlipidemia. In recent years, antioxidants have been subjected to epidemiological studies4 that have related their consumption to a reduction in the incidence of oxidative damage related diseases.Methods: Hypercholesterolemia was induced in rats by administration of high cholesterol diet for 30 days in standard rat chow diet. Rats were divided into four groups of six each. Group-I and II with intake of normal diet and High cholesterol diet respectively. Group III and IV are given high cholesterol diet along with Lutein 50mg/kg and Atorvastatin 5mg/kg orally once daily respectively. At the end of 30 days animals were subjected to overnight fasting. Blood samples were drawn by retro-orbital puncture for biochemical analysis. The animals were sacrificed after thiopentone injection and liver and aorta were dissected out and processed for histopathological study and biochemical analysis.Results: Lutein treated group showed even more significant reduction in TBARS levels than the normal control group and Atorvastatin treated group. The efficacy of Lutein in slowing down the atherosclerosis and fatty infiltration of liver is proved in this study.Conclusions: Hence the present study had shown significant hypolipidemic, antiatherogenic and antioxidant effect of Luetin in Hyperlipidemic rats.

EFFICACY OF CHONDROITIN SULFATE WITH GLUCOSAMINE VERSUS DIACEREIN IN GRADE II AND III OSTEOARTHRITIS KNEE: A RANDOMIZED COMPARATIVE STUDY

ABSTRACTObjective: Osteoarthritis (OA), the most common joint disease has led to great morbidity and disability. Symptomatic slow acting drugs for OA, whichincludes glucosamine sulfate, chondroitin sulfate, and diacerein provides symptom relief and structure-modifying effects in OA knee. Our aim was toassess the efficacy and safety of chondroitin sulfate with glucosamine versus diacerein in Kellgren-Lawrence Grade II and III OA knee patients.Methods: After approval from Institutional Human Ethics Committee and after getting written informed consent patients were randomized toGroup A: Tablet chondroitin sulfate (400 mg) with glucosamine (500 mg) combination thrice a day or Group B: Capsule diacerein 50 mg, twice aday orally both after food. Out of 88 patients screened, 75 of them entered the study. A total of 15 patients failed to complete the study. Remaining60 patients completed with 30 patients in each group. They were assessed for pain using visual analogue scale (VAS) from baseline and followed-upat 3, 12, 24 weeks.Results: Baseline characteristics in both the groups were matching without any significant difference. At 24 weeks there was reduction in VAS from6.76 to 1.96 (71.01%) in Group A and from 6.8 to 3.53 (48.09%) in Group B. There was significant difference between the groups with Group Asignificant over Group B in VAS. Thus, the effect of drug in Group A on pain reduction was greater than Group B.Conclusion: The use of chondroitin sulfate with glucosamine combination resulted in improvement in VAS better than diacerein in OA knee.Keywords: Osteoarthritis, Chondroitin sulfate with glucosamine combination, Diacerein, Visual analogue scale

Implementing Neural Fuzzy Rough Set and Artificial Neural Network for Predicting PCOS

Polycystic ovarian syndrome (or polycystic ovary syndrome – PCOS) is a multifarious form in which a woman’s ovaries are normally larger than standard. The term ‘Polycystic’ defines that the ovaries comprise of numerous cysts or follicles to facilitate hardly ever nurture towards ripeness or generate eggs accomplished of being fertilized. One third of women could contain polycystic ovaries observed on an ultrasound, however it does not all have PCOS. PCOS is comparatively universal, especially for sterile women. It concerns about 12 to 18 per cent of women of reproductive age (between late adolescence and menopause). In approximate 70 per cent of this kind of cases remain undiagnosed. In our previous researches, we have proposed a new feature selection technique and hybrid approach and in this present investigation, we implement these proposed algorithms to forecast the PCOS disease among women. In addition to above analysis, we evaluate the effect of the proposed algorithms with other existing methods

Study of Variations in the Origin and the Colic Branches of the Superior Mesenteric Artery

INTRODUCTION : Superior mesenteric artery shows variation in its origin and its branching pattern. A sound knowledge of the presence of variations of Superior mesenteric artery is important for Surgeon, Physician, Radiologist, Gastroenterologist and Vascular Surgeon. AIM OF STUDY : Examining the pattern of variations in the origin of the Superior mesenteric artery and its colic branches, mainly in South Indian population. Comparing the variations with the previous study. PARAMETER : • Level of origin, • Course of artery, • Level of termination, • In branching pattern, • Relation with coeliac trunk, • Relation with pancreas. MATERIALS AND METHODS : A total number of fifty Superior mesenteric arteries were studied. Thirty Superior mesenteric arteries were studied from the cadavers by dissection method at Government Stanley Medical College. Twenty Superior mesenteric arteries pictures of CT angiogram was taken at Department of Radiology, Government Stanley Medical College. RESULTS : The following findings were seen in the present study. • Normal origin of Superior mesenteric artery from abdominal aorta. • Superior mesenteric artery and coeliac trunk arose as a common trunk from the abdominal aorta. • Superior mesenteric artery and Inferior pancreatico duodenal artery had a common origin from the abdominal aorta. • Absence of middle colic artery. • Common origin of Right colic artery arising from the ileocolic artery. • Ileocolic and right colic artery had a common trunk from Superior mesenteric artery. • Appendicular artery arising from inferior division of ileocolic artery. • Double appendicular arteries,one from ileocolic artery before division and the other from the inferior division of ileocolic artery. CONCLUSION : A thorough knowledge about the normal pattern and abnormal pattern of Superior mesenteric artery and its branches are helpful for correct interpretation of any invasive procedures and resection of colon for carcinoma, intestine transfers, resection of small and large intestines and appendicectomy and embolectomy

SYNTHESIS AND EVALUATION OF PHTHALATE ANALOGUE OF DICLOFENAC AGAINST FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS IN RAT

Objective: The objective of the present study is to evaluate the effect of Phthalate analogues of diclofenac in Freund’s complete adjuvant (FCA) induced Arthritis in the rat. Methods: Twenty four female albino wistar rats were enrolled in this study and are divided into 4 groups (six each). The groups were designed as follows: Group I: vehicle control, Group II: arthritic control, Group III: diclofenac treated, Group IV: phthalate analogue of diclofenac treated. Various assessments such as anti-arthritic activity, biochemical estimations, haematological parameters, ulcerogenesis, radiological and histopathological studies were evaluated. Results: Arthritic control group exhibited significant increase in the level of paw volume, arthritic score (p<0.0001), Serum glutamic pyruvic transaminase (SGPT) (p<0.001), Serum glutamic oxaloacetic transaminase (SGOT) p<0.01), rheumatoid arthritis factor, C-reactive protein (CRP), White Blood Cells (WBC), Creatinine and uric acid and a significant decrease in Red Blood Cells (RBC). Increased swelling of joints, bony destruction and profound ulceration were observed in the Arthritic control group. All these conditions were reversed in diclofenac and phthalate analogue of diclofenac groups. Conclusion: We conclude that phthalate analogue of diclofenac shows potent anti-arthritic activity with milder ulceration when compared to diclofenac treatment

Rice landraces of Tamil Nadu –a review

India being a floristically diverse and genetically rich nation is endowed with huge rice germplasm collections. As per the vedic evidences, in olden days about 400 landraces of paddy had been in cultivation in Tamil Nadu which is an agrarian state of India. But due to the introduction of high yielding cultivars these landraces went out of cultivation leading to genetic erosion. However, a few hundreds of landraces are in cultivation in small pockets in Tamil Nadu. So it is our bound duty to conserve the available landraces, sort out the duplications and maintain the identity of the cultivars by the way of precise morphological, biochemical and molecular characterization for the valuable traits possessed by these landraces. According to ancient Tamil literature, some of these landraces are resistant to biotic and abiotic stresses while some others are known for their nutritional and therapeutic values in rice. Landraces of Tamil Nadu origin were extensively studied for their tolerance against abiotic stresses whereas the clinical validation of several of the landraces with nutritional and medicinal value is gaining importance in view of the growing interest of the consumers for a health conscious diet. In this context, traditional knowledge about the indigenous cultivars will help to explore the scientific basis of the nutraceutical values of the traditional cultivars by the plant breeders for sustaining food as well as the nutritional security and for overcoming the future challenges

Structural Determination of Functional Units of the Nucleotide Binding Domain (NBD94) of the Reticulocyte Binding Protein Py235 of Plasmodium yoelii

Invasion of the red blood cells (RBC) by the merozoite of malaria parasites involves a large number of receptor ligand interactions. The reticulocyte binding protein homologue family (RH) plays an important role in erythrocyte recognition as well as virulence. Recently, it has been shown that members of RH in addition to receptor binding may also have a role as ATP/ADP sensor. A 94 kDa region named Nucleotide-Binding Domain 94 (NBD94) of Plasmodium yoelii YM, representative of the putative nucleotide binding region of RH, has been demonstrated to bind ATP and ADP selectively. Binding of ATP or ADP induced nucleotide-dependent structural changes in the C-terminal hinge-region of NBD94, and directly impacted on the RBC binding ability of RH.In order to find the smallest structural unit, able to bind nucleotides, and its coupling module, the hinge region, three truncated domains of NBD94 have been generated, termed NBD94(444-547), NBD94(566-663) and NBD94(674-793), respectively. Using fluorescence correlation spectroscopy NBD94(444-547) has been identified to form the smallest nucleotide binding segment, sensitive for ATP and ADP, which became inhibited by 4-Chloro-7-nitrobenzofurazan. The shape of NBD94(444-547) in solution was calculated from small-angle X-ray scattering data, revealing an elongated molecule, comprised of two globular domains, connected by a spiral segment of about 73.1 A in length. The high quality of the constructs, forming the hinge-region, NBD94(566-663) and NBD94(674-793) enabled to determine the first crystallographic and solution structure, respectively. The crystal structure of NBD94(566-663) consists of two helices with 97.8 A and 48.6 A in length, linked by a loop. By comparison, the low resolution structure of NBD94(674-793) in solution represents a chair-like shape with three architectural segments.These structures give the first insight into how nucleotide binding impacts on the overall structure of RH and demonstrates the potential use of this region as a novel drug target

Necessities and ways of combating dissatisfactions at workplaces against the Job-Hopping Generation Y employees

The vital role of the private sector in the overall development of a country is crucial as proven by private tertiary industries. Despite its phenomenal success all over the world, private sectors are facing enormous challenges due to the frequent turnover of Generation Y (Gen Y). Such phenomena cause massive overt and covert losses. Gen Y workers are optimistic, practical and often have attrition tendencies at workplaces. Extensive literature indicates the turnover problem of Gen Y remains unresolved. Frustration acts as the most crucial factor contributing to frequent turnover. The employers state similar effects. Turnover studies have been performed in the Western sense, though turnover problems exist all over the world, which include a developing country like Bangladesh. Another problem is the turnover rate in the public sector is lower than in the private sector. Since each company strives to achieve the best output and lower turnover to avoid brain drain, they refrain from high turnover costs and maintaining competent staff. This quantitative study discovers that there is an urgent need to establish retention-friendly approaches to mitigate Gen Y frustration and retain them in the workplace. Gen Y retention approaches, management initiatives, soft HRM, work-life balance, and employee satisfaction are vital resources for Gen Y retention in the private sector