Epidemiology, prevention and control of oral diseases in pediatric subjects

Caries and periodontal diseases are a neglected epidemic by millions of Italians who suffer unnecessarily from them. Both diseases are preventable and the combination of high prevalence, high morbidity and relative inattention from the National Health Service (NHS), makes caries and periodontal disease a significant public health problem. In this perspective, the World Health Organization and the University of Milan have promoted a national epidemiological study aimed at a sample of 4, 6 and 12-years-old students from schools in the North, Central and South of Italy. The study provides for the administration of a questionnaire to parents and a dental examination carried out at school by dentists trained by the WHO. In our town the epidemiological study planning and the survey were carried out by professors of the School of Specialization in "Pediatric Dentistry" (Prof. G. Giuliana and Prof. G. Pizzo) supported by specialist dentists from the same School, calibrated according to the WHO methodology. The survey was carried out between 2017 and 2019 involving 2701 children attending schools in the 8 districts of the town. The parents were sent a letter which explained the nature of the survey and contained a pre-printed form for the issue of informed consent to participate in the survey with a questionnaire regarding the family nuclear, the oral hygiene and eating habits of the minor and the child's previous dental experiences. The ICDAS (International Caries Detection and Assessment System) was used to detect the prevalence of carious lesions. The dentist used for each child visited a dental mirror and the CPI (Community Periodontal Index) index for periodontal assessment. Preliminary results showed that 25.3% of 12-years-old students had gingival bleeding and 41.1% had tartar. The caries index (ICDAS) shows us that as early as 4 years, 20% of children have initial carious lesions, 37% have dentine caries and that 34.38% have highly destructive caries. At 12 years, 34.95% had initial carious lesions, 46% had cavities that already affected dentin and that 42.44% had highly destructive cavities. The exigence to implement a program of prevention / early treatment of caries/gingivitis in pediatric subjects living in Palermo, since the first months of child's life, was born from the data analysis. The project "Un sorriso per 54 tutti i bambini", carried out at the U.O. of "Pediatric Dentistry" of Policlinico Paolo Giaccone in Palermo, was therefore finalised in order to 1) improve efficiency and effectiveness in the promotion of the oral health of minors, through the creation of a preventive / assistance route of significant social health impact; 2) assess the effectiveness of the preventive methodologies adopte

Two-photon imaging of cell-specific fluorophores in transgenic mice – an exploratory tool to study mechanisms of white matter injury

Relatively little is known about specific pathways leading to structural and functional disruption of axons and glial cells in white matter. Because focal cerebral ischemia in humans damages both gray and white matter, an understanding of white matter injury is important in devising potential therapeutic approaches. We have developed a novel brain slice model from transgenic mice under control of cell-specific promoters to understand interactions between oligodendrocytes and axons under high resolution twophoton microscopy. Our data extends over previous findings the vulnerability of oligodendrocytes and axons both in culture and in slice preparations to glutamate toxicity during stroke and hypoglycemia. Conditions as different as stroke, trauma, perinatal brain injury, and multiple sclerosis may share common mechanisms of white matter injury.N/

A Scan-to-BIM Approach for the Management of Two Arab-Norman Churches in Palermo (Italy)

The paper shows the results of the research activities carried out by the Department of Engineering at the University of Palermo (Italy), which assessed the application of the Heritage Building Information Modelling (HBIM) methodology through a Scan-to-BIM approach to two local churches belonging to the medieval period. This project was motivated by a renewed interest from the city administrators towards the conservation of cultural heritage dating back to the Arab-Norman domination in Sicily since one of the two buildings was included in the UNESCO World Heritage Sites list in 2015. The morpho-typological style of the churches has been acquired by high-detailed 3D surveys, which provided the base for two HBIM models suited to render the peculiarity of these buildings at their best. The BIM environment allowed both the geometrical representation of all the architectural elements and their further enrichment with the integration of non-geometric data and semantic signification through a knowledge-based workflow. This process led to a hierarchical organization of two high-accuracy digital replicas and to the creation of a database containing all of the architectural items typical of the Arab-Norman style, aimed to share the awareness of its conservation and to match all of the Cultural Heritage requirements. In the future, the features in this database can be shared with other specialists as reference objects for further studies on cultural heritage sites in the UNESCO list

Separaxion anxiety in pediatric migraine without aura: A pilot study

Background: Separation anxiety (SA) can be defined as the fear reaction and protest manifested by children when the main caregivers move away from him/her or in front of unfamiliar person. SA near eight months may be considered as an important and normal phase of the correct and typical social neurodevelopment. Aims of the present pilot study is assessing the prevalence of separation anxiety in a population of patients with migraine without aura (MwA). Materials and methods: 119 children (69 males) suffering from MwA (mean age 1.78 ± 7:59) were consecutively recruited. The control population consisted of 231 (114 males) healthy subjects similar for age (7.64 ± 1:34; p = 0.768) and gender (p=0.987) The Screen for child anxiety related emotional disorders (SCARED) test was used to assess the prevalence of separation anxiety among MwA children. Results: Healthy individuals are on average less affected (mean 4.72 ± 0:32) of the Separation Anxiety Disorder respect of MwA children (mean 6.83 ± 0.97; p < 0.001) (Figure 1). Conclusion. MwA presents many psychiatric comorbidities and among ones separation anxiety may be considered in the clinical and therapeutic management of pediatric primary headache

Behavioural disorders in children and adolescents: A conceptual review about the therapeutic alliance with family and school

Aim: In disruptive behavioral disorders, given the wide range of symptomatic manifestations and the complexity of the sociofamiliar contexts in which they develop, it is now proven that more visible and more stable results can be achieved over time through multimodal and multidimensional interventions. These are accomplished through the integration of psychotherapeutic interventions for the child and parents, counseling interventions for all the various practitioners who come into contact with the child in school, sports, and social settings, through the possibility of organizing multiple settings in patient can be followed by several health professionals such as child and adolescent neuropsychiatrist, neuropsychomotricist, occupation therapist, psychologist

Review about comorbidities of behavioural disorders in children and adolescents: The focus on attention-deficit/hyperactivity disorder

Disruptive behavior disorders (DBD) present high comorbidity rate mainly for opposite-defiant disorders that are frequent among children, adolescents and adults affected by with attention deficit and hyperactivity disorder (ADHD), probably as result of common temperamental risk factors such as attention, distraction, impulsivity. ADHD tend to manifest in about 50% of individuals diagnosed as disruptive behavioral disorders

Contenimento naturale di Bactrocera oleae (Rossi): clima o parassitoidi? Confronto tra Western Cape (Sud Africa) e Sicilia

Bactrocera oleae (Rossi), mosca delle olive, e\u300 presente anche in Sud Africa, ma finora non si sono avute notizie di infestazioni economicamente rilevanti negli oliveti. L\u2019accertata presenza di un maggior numero di braconidi parassitoidi della mosca delle olive rispetto alle aree mediterranee e\u300 stata ed e\u300 considerata da molti autori la principale causa di queste minori infestazioni, senza che pero\u300 siano stati eseguiti in Sud Africa adeguati studi sulle infestazioni da B. oleae e sui fattori cli- matici delle aree interessate. Analizzando recenti dati sui livelli d\u2019infestazione di B. oleae registrati su olivo coltivato e selvatico nel Western Cape e in Sicilia, appaiono simili in una normale annata fino a meta\u300 estate, ma sono nettamente differenti a fine estate-inizio autunno, quando in Sicilia il clima diviene piu\u300 umido. Da una puntuale analisi dei corrispondenti dati climatici registrati nelle due aree e\u300 infatti emersa una sostanziale differenza nel decorso piu\u300 caldo e secco degli ultimi tre mesi precedenti la raccolta nel Western Cape; questo periodo invece in Sicilia e\u300 caratterizzato da temperature piu\u300 fresche e un aumento dell\u2019umidita\u300 relativa che favorisce l\u2019impennata delle infestazioni di B. oleae. Nei quattro mesi presi in considerazione si rileva anche una significativa differenza nell\u2019escursione termica, maggiore nel Western Cape, dovuta a minime notturne piu\u300 basse. Da un confronto dei livelli di parassitizzazione di B. oleae del Western Cape (Sud Africa) e dell\u2019area costiera della Provincia di Trapani, recentemente registrati su olivo colti- vato e selvatico (Olea europaea subsp. cuspidata in Sud Africa, Olea europaea subsp. europaea var. sylvestris in Sicilia) non sono emerse sostanziali differenze quantitative, pur confer- mando che in Sud Africa i principali parassitoidi sono tre bra- conidi (Utetes africanus (Sze\u301pligeti), Psyttalia lounsburyi (Silvestri) e Bracon celer (Sze\u301pligeti)), con il primo preva- lente sull\u2019olivo selvatico e l\u2019ultimo sul coltivato, mentre in Sicilia il braconide parassitoide Psyttalia concolor (Sze\u301pligeti) prevale sia sull\u2019olivo selvatico che sul coltivato. Comunque in entrambe le aree la parassitizzazione su B. oleae non rag- giunge elevati ed efficaci livelli. Il clima, e non la parassitizzazione dovuta ai braconidi, appare il piu\u300 importante fattore di contenimento di B. oleae anche in Sud Africa. L\u2019introduzione di parassitoidi specifici della mosca delle olive e\u300 necessaria nelle aree colonizzate di recente dove essi mancano, ma i tentativi di fornir loro una maggiore dis- ponibilita\u300 di larve dell\u2019ospite mediante l\u2019impianto di cultivar d\u2019olivo a maturazione e permanenza dei frutti piu\u300 differen- ziata, potrebbe produrre risultati certamente piu\u300 negativi che positivi nei confronti della presenza e dei livelli d\u2019infesta- zione di B. oleae sull\u2019olivo coltivato, come avviene nelle aree pandacie dove cresce spontaneo l\u2019olivastro.Natural environmental control of Bactrocera oleae (Rossi): climate or parasitoids? A comparison between the Western Cape of South Africa and Sicily. Bactrocera oleae (Rossi), the olive fruit fly is considered not a continuosly serious pest of olive trees in the Western Cape of South Africa, in spite of the climate similar to Mediterranean areas. South African braconid parasitoids of B. oleae are more numerous than in Mediterranean areas, and until now their action has been considered the factor lowering the level of infestation due to the olive fruit fly, but no deep studies on its infestation levels and climatic factors influencing them were carried out in the past. Analyzing recent data on infestation levels collected in the Western Cape and Sicily, they appear similar in a regular mid- summer, differing at the end of summer-beginning of autumn, when in Sicily the climate becomes more humid than in the Western Cape. A comparison of climatic data regarding four years underlines that Somerset West and Franshhoek, in comparison with Trapani, have significantly lower minimum daily temperatures, a higher daily thermal excursion and a lower relative humidity in the last three months preceding harvesting. Parasitization rates on B. oleae of Western Cape and Sicily, recorded on both cultivated and wild olives (Olea europaea subsp. cuspidata in South Africa, Olea europaea subsp. europaea var. sylvestris in Sicily) are not substantially different, confirming that in South Africa three braconids, Utetes africanus (Sze\u301pligeti), Psyttalia lounsburyi (Silvestri) and Bracon celer (Sze\u301pligeti), are the main parasitoids, with the first one as leader in wild olives and the last one as leader in cultivated ones, while in Sicily the braconid Psyttalia concolor (Sze\u301pligeti) is the main parasitoid in both wild and cultivated olives. Nevertheless parasitism on B. oleae doesn\u2019t reach effective levels of control in bats ragions. The climate, instead of parasitization due to braconids, is the main environmental factor limiting the olive fruit fly infestations in the Western Cape of South Africa. The introduction of parasitoids specific to the olive fruit fly is necessary in new invaded areas where they lack, but the attempt of providing them a more available amount of host fruits along the year, planting olive trees bearing fruits up to spring, could bring serious problems as those typical of Mediterranean areas where the European wild olive naturally grows

Application of design for environment principles combined with LCA methodology on automotive product process development: The case study of a crossmember

none4noThe existing Community regulation pushes the carmakers to design eco-sustainability of the vehicle over its life cycle to limit the consequences of the current state and the expected growth of the sector. In this sense, one of the primary aim is reducing raw materials consumption and emissions through the adoption of innovative materials and technologies. This implies the need for the carmakers to integrate Design for Environment (DfE) principles at the early Research and Development (R&D) stage. The article presents a concreate example of integration of DfE and LCA methodology application in the R&D process of a vehicle component produced by Magneti Marelli. The study allowed drawing a balance between the advantages of a lightweight solution with respect to the standard one both from performance and environmental point of view.openMaltese, S.; Delogu, M.; Zanchi, L.*; Bonoli, A.Maltese, S.; Delogu, M.; Zanchi, L.*; Bonoli, A

Environmental assessment of light weighting solutions for automotive components: results, trade‐off and challenges from real case studies

In the last few decades, the automotive industry is facing the most deal with sustainability programs due to the increase of legislate limits on CO2 emissions and vehicle recyclability rate. Consequently, decisions on products design and development go together with environmental considerations, by starting to look for the employment of lighter materials, thus reducing vehicle mass weight and therefore fuel consumption and CO2 emissions during the dominant operation stage of a vehicle’s life cycle. To tackle this problem many of today automotive components are made of alternative materials like plastics, polymer composites, lighter metals which should lead to weight reduction with the same mechanical performances. Magneti Marelli® designs and produces hi-tech systems and components for the automotive sector representing a significant contribution on vehicle mass weight with a roughly 15% portion of incidence. So, in accordance to the environmental regulations, the Company has started to get involved into sustainability programs by focusing attention on the environmental impact of its products. In particular since 2012 Magneti Marelli has included in its mission the “improvement of environmental and energy performances of products and relatives processes during their whole life cycle, through innovative methodologies that assess the potential impacts in a quantitative way”, in this way highlighting the importance of meeting the increasing stakeholders’ expectations and their requests for transparency in results’ communication. This work addresses the main outcomes stemmed from the several LCA studies carried out over different components in terms of materials and technologies production allowing a wider environmental conscious related to the usage of different materials and manufacturing processes. Results showed that the materials employed offer the major contribution on the total impact especially for raw materials extraction and production and for the vehicle use phase, with a further substantial difference connected to the use of virgin instead of recycled materials. The main discussed points will be: i) the trade-off between production phase and use phase impacts; ii) End-of-Life analysis at component level beside the ISO 22628:2002 for the whole vehicle; iii) critical analysis and selection of environmental indicators significant for the automotive sector. Keywords Automotive sector, Life Cycle Assessment, vehicle component, Sustainable Manufacturing, Design for Environment, composites, light weightin