Sexuality Among Adults with Congenital Deafblindness: A Cross-Sectional Survey Study Among Primary Carers

Research investigating the sexuality of individuals with physical or intellectual disabilities is increasing. However, little is known about the sexuality of people with congenital deafblindness (CDB). The aim of the current study was to create a profile of the sexuality of adults with CDB in Denmark. Data was collected from the primary carers of 95 adults with CDB by use of a survey with questions about sexual behavior, the object of sexual behavior, level of sexual frustration, and pedagogical support for sexual satisfaction. The data were analysed with regard to gender, age, severity of deafblindness, communication, activities of daily living (ADL), cognitive abilities, and carer characteristics. The results revealed that approximately half the number of participants showed sexual behavior while the other half did not. In the majority of cases, sexual behavior was self-stimulation, while, for the rest, sexual behavior was directed towards other people and/or objects. Around one out of ten participants was provided with pedagogical support to help satisfy their sexual needs. Sexual behavior was significantly associated with high scores for communication skills, ADL, and cognitive abilities. Further, high ADL and cognitive abilities were associated with the provision of pedagogical support for sexual satisfaction. Around one out of ten participants, all of whom were men, experienced sexual frustrations. The findings of the current study—the first quantitative study on sexuality among individuals with CDB—are comparable to the findings of studies among individuals with developmental disorders and underline the need for sexuality-related support for individuals with disabilities including those with CDB

Updated CPT-based p–y formulation for laterally loaded piles in cohesionless soil under static loading

The p–y method is currently the most popular design method to predict the response of piles to lateral load. The authors had previously used numerical methods to develop a cone penetration test (CPT)-based p–y formulation for piles in sand and this has subsequently been shown by independent verification to show considerable promise. This paper addresses some of the uncertainties associated with the original p–y formulation by examining the influence of pile bending stiffness, the presence of a water table, the cross-sectional shape of the pile and soil non-homogeneities. Numerical experiments are presented examining these four effects and lead to an updated proposal for a CPT-based p–y formulation. This formulation, which is consistent with the original proposal, is validated against three-dimensional finite-element calculations and data obtained from a full-scale offshore monopile foundation supporting a wind turbine

Numerical derivation of CPT-based p-y curves for piles in sand

The formulations for the lateral load-displacement (p-y) springs conventionally used for the analysis of laterally loaded piles have been based largely on the back-analysis of the performance of small-scale instrumented piles subjected to lateral load. Although such formulations have been employed with much success in industry, their applicability to large-diameter piles, such as those used to support offshore wind turbines, is uncertain and has necessitated further research in this area. Moreover, with the growth in popularity of in-situ cone penetration tests (CPTs), there are demands for a theoretically supported direct method that can enable the derivation of p-y curves from the CPT end resistance (q c). In this paper, a numerical derivation of CPT-based p-y curves applicable to both small- and large-diameter laterally loaded single piles in sand is presented. Three-dimensional finite-element analyses are performed using a non-linear elasto-plastic soil model to predict the response of single piles in sand subjected to lateral loads. The corresponding CPT q c profile is derived using the same soil constitutive model by way of the cavity expansion analogue. An extensive series of computations of the lateral pile response and CPT q c values is then employed to formulate a direct method of constructing p-y curves from CPT q c values. The proposed method is shown to be generally consistent with existing empirical correlations and to provide good predictions in relation to the measurements obtained during lateral load tests on instrumented piles in an independent case study

The Response of Driven Single Piles Subjected to Combined Loads

The behaviour of piles subjected to lateral load has generally been investigated experimentally using free-headed piles with a lateral load applied close to the pile head. In practice, however, there is some degree of restraint at the head of many piles and these are often subjected to a combination of lateral and vertical loads. The case history described in this paper involved full-scale field experiments comprising instrumented precast concrete piles subjected to a range of loading conditions including combined lateral and axial loading with partial rotational restraint at the pile head. The pile instrumentation, which included electrolevels and electrical resistance strain gauges, allowed accurate determination of the lateral soil reaction-lateral displacement (p-y) response adjacent to the test piles. This paper concentrates on the analysis and interpretation of the test data for the pile subjected to combined loading. These results are presented in conjunction with test data from an adjacent pile subjected to the same lateral load to allow the difference in behaviour to be evaluated

Adult midgut expressed sequence tags from the tsetse fly Glossina morsitans morsitans and expression analysis of putative immune response genes

BACKGROUND: Tsetse flies transmit African trypanosomiasis leading to half a million cases annually. Trypanosomiasis in animals (nagana) remains a massive brake on African agricultural development. While trypanosome biology is widely studied, knowledge of tsetse flies is very limited, particularly at the molecular level. This is a serious impediment to investigations of tsetse-trypanosome interactions. We have undertaken an expressed sequence tag (EST) project on the adult tsetse midgut, the major organ system for establishment and early development of trypanosomes. RESULTS: A total of 21,427 ESTs were produced from the midgut of adult Glossina morsitans morsitans and grouped into 8,876 clusters or singletons potentially representing unique genes. Putative functions were ascribed to 4,035 of these by homology. Of these, a remarkable 3,884 had their most significant matches in the Drosophila protein database. We selected 68 genes with putative immune-related functions, macroarrayed them and determined their expression profiles following bacterial or trypanosome challenge. In both infections many genes are downregulated, suggesting a malaise response in the midgut. Trypanosome and bacterial challenge result in upregulation of different genes, suggesting that different recognition pathways are involved in the two responses. The most notable block of genes upregulated in response to trypanosome challenge are a series of Toll and Imd genes and a series of genes involved in oxidative stress responses. CONCLUSIONS: The project increases the number of known Glossina genes by two orders of magnitude. Identification of putative immunity genes and their preliminary characterization provides a resource for the experimental dissection of tsetse-trypanosome interactions

Mass Drug Administration and beyond: how can we strengthen health systems to deliver complex interventions to eliminate neglected tropical diseases?

Achieving the 2020 goals for Neglected Tropical Diseases (NTDs) requires scale-up of Mass Drug Administration (MDA) which will require long-term commitment of national and global financing partners, strengthening national capacity and, at the community level, systems to monitor and evaluate activities and impact. For some settings and diseases, MDA is not appropriate and alternative interventions are required. Operational research is necessary to identify how existing MDA networks can deliver this more complex range of interventions equitably. The final stages of the different global programmes to eliminate NTDs require eliminating foci of transmission which are likely to persist in complex and remote rural settings. Operational research is required to identify how current tools and practices might be adapted to locate and eliminate these hard-to-reach foci. Chronic disabilities caused by NTDs will persist after transmission of pathogens ceases. Development and delivery of sustainable services to reduce the NTD-related disability is an urgent public health priority. LSTM and its partners are world leaders in developing and delivering interventions to control vector-borne NTDs and malaria, particularly in hard-to-reach settings in Africa. Our experience, partnerships and research capacity allows us to serve as a hub for developing, supporting, monitoring and evaluating global programmes to eliminate NTDs

Bearing Capacity and Load-Displacement Behavior of Rigid Pads on Soft, Sensitive, Clay

The paper describes tests on rigid square pads at the UK national soft clay research site at Bothkennar, Scotland. The work was performed as a low cost adjunct to the instrumented pile research described by Lehane and Jardine (1992). Its aims were to investigate (i} bearing capacity, (ii) load-displacement response to short and long term loading, (iii) the applicability of relevant theories and (iv) relationships between soil properties determined in-situ and those measured in high quality laboratory tests

Verification of numerically derived CPT based p-y curves for piles in sand

This paper examines the potential of a numerically derived CPT-based formulation for p-y curves in sand (Suryasentana & Lehane 2014) to predict the response observed in lateral load tests conducted on six piles in four different sand deposits. A summary of the methodology employed in the derivation of this formulation is first described before presenting information related to each of the case histories examined. The lateral load displacement data measured in these case histories are shown to compare well with predictions obtained using the p-y formulation. This agreement should encourage further refinement of the formulation and ultimately the direct use of CPT qc profiles for the analysis of laterally loaded piles in sand

International Glossina Genome Initiative 2004-2014: a driver for post-genomic era research on the African continent

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub- Saharan Africa and includes at least 50% of the population of theDemocratic Republic of the Congo [1]. Trypanosoma brucei gambiense accounts for more than 98% of the infections in central and West Africa, the remaining infections being from Trypanosoma brucei rhodesiense in East Africa [2]. The parasites are transmitted to the hosts through the bite of an infected tsetse fly. Disease control is challenging as there are no vaccines, and effective, easily delivered drugs are still lacking. Treatment invariably involves lengthy hospitalization, with both medical and socioeconomic consequences.Web of Scienc

Development of a Novel Biological Intervertebral Disc Scaffold

Back pain is a major public health issue in our society, and is strongly correlated with the degeneration of intervertebral discs (IVDs). Current therapies are conservative or surgical, and no attempt to regenerate the IVD. The first goal of our project is to create a fully decellularized bovine caudal IVD to be used as a scaffold on which to seed adult human stem cells in an attempt to engineer a healthy, replacement IVD for patients suffering from IVD degeneration and lower back pain. The goal of decellularization is to eliminate DNA content while retaining glycosaminoglycan (GAG) content. Eliminating DNA content will prevent a foreign body response by the host\u27s immune system once the IVD is implanted. GAG is responsible for forming interfibrillar bridges with collagen fibrils and thus assisting in resisting compressive and tensile forces. By retaining GAG content in our decellularized IVDs we will maintain structural integrity of the extracellular matrix. The IVDs closest to the base of the bovine tail were targeted, because they are similar in size and biochemistry to the human IVD. We use a mix of conventional methods including freeze thaw, sonication and agitation in a solution of sodium dodecyl sulfate (SDS) and ethylene diamine tetraacetic acid (EDTA). After decellularization, half of each IVD was placed in a tissue cassette and put formalin in preparation for histological analysis, and the other half was frozen prior to biochemical analysis (DMMB and PicoGreen assay). Our results thus far are promising in eliminating DNA content but show we have a large room for improvement in retaining GAG content