V&V and more in Nuclear Thermal-Hydraulics

1) OUTLINE OF CURRENT/ADVANCED V&V DOMAIN OF SIMULATION FOR SYS TH CODES Precision Objectives Qualitative and Quantitative Accuracy Evaluation CONSIDERATION OF 116 TH PHENOMENA SCALING PART OF V&V – RECENT FINDINGS INDEPENDENT ASSESSMENT & ASSESSMENT OF ASSESSMENT 2) THE MOTIVATION FOR V&V&C 3) THE DEFINITION OF ‘C’ = CONSISTENCY 4) THE ROADMAP FOR V&V&

Specialists Meeting on Transient Thermal-hydraulics in Water Cooled Nuclear Reactors (SM-TH)

Design of an international Specialists Conference in nuclear Thermal-hydraulics proposed to be held in Madrid in 2020 within the framework of OECD/NEA/CSNI activitie

Coupling of Thermal-Hydraulics and I&C for Licensing Analyses

The BEPU (Best Estimate Plus Uncertainty) approach constitutes a valuable and, under some circumstances, an unavoidable tool to demonstrate the safety of NPP (Nuclear Power Plants). Within the licensing process of the Atucha II PHWR (Pressurized Heavy Water Reactor) the BEPU approach has been followed for issuing the Chapter 15 of the FSAR (Final Safety Analysis Report). Namely, the BEPU approach replaced the classical conservative approach. The selection of PIE (Postulated Initiating Events) and, the analysis of each PIE by best estimate models supported by uncertainty evaluation constitute key elements for BEPU. An outline of the BEPU approach is included in the paper, which, otherwise focuses on the simulation needs for Instrumentation and Control (I & C). Sample results from the analysis of PIE are included in the paper. It is demonstrated that the simulation of I&C is necessary to evaluate the safety of the concerned NPP; furthermore, the simulation shall be part of the accident analysis in Chapter 15 of FSA

Recent Applications of RELAP5-3D at GRNSPG

CNA2 : FSAR activities Standard Consolidated Reference Experimental Database MASLWR benchmark OECD benchmarks CHF calculation in low mass flux condition Turbulence effects in Relap5-3

Prospective For Nuclear Thermal Hydraulic Created By Ongoing And New Networks

International audienceThis paper introduces the FONESYS, SILENCE and CONUSAF projects run by some of the leading organizations working in the nuclear sector.The FONESYS members are developers of some of the major System Thermal-Hydraulic (SYS-TH) codes adopted worldwide, whereas the SILENCE members own and operate important thermal-hydraulic experimental facilities. The two networks work in a cooperative manner and have at least one meeting per year where top-level experts in the areas of thermal-hydraulic code development and experimentation are gathered.The FONESYS members address various topics such as hyperbolicity and numerics in SYS-TH codes, 3-field modeling, transport of interfacial area, 3D modeling, scaling of thermal-hydraulic phenomena, two-phase critical flow (TPCF), critical heat flux (CHF), and others. As part of the working modalities, some numerical benchmarks were proposed and successfully conducted by the network, addressing some of the most relevant topics selected by the FONESYS members.On the other hand, SILENCE addresses topics such as identification of current measurement needs and main gaps for further SYS-TH and CFD codes development and validation, definition of similar tests and counterpart tests in Integral Tests Facilities (including containment thermal-hydraulics) to be possibly conducted on Members' test facilities, scaling issue, and other subjects. Furthermore, SILENCE organized a Specialists Workshop on Advanced Instrumentation and Measurement Techniques for Nuclear Reactor Thermal-Hydraulics (SWINTH) which was held in Italy on June 2016. A second edition of the Workshop, namely SWINTH-2019, will be held in Italy in 2019 under the umbrella of the OECD/NEA/CSNI/WGAMA.Recently a new initiative is being taken by launching an international consortium of nuclear thermal-hydraulics code users, the CONUSAF. The main idea is to enhance the interactions between the users of computational tools in nuclear TH, noticeably including SYS-TH and CFD codes, the code developers and the experimentalists. The proposed initiative is expected to have a positive impact on the entire ecosystem by pursuing the assessment of the current code limitations and capabilities, analyzing and addressing issues raised by the users and promoting common RandD efforts on topics of high relevance

Viral load, tissue distribution and histopathological lesions in goats naturally and experimentally infected with the Small Ruminant Lentivirus Genotype E (subtype E1 Roccaverano strain)

Small Ruminant Lentivirus (SRLV) subtype E1, also known as Roccaverano strain, is considered a low pathogenic virus on the basis of natural genetic deletions, in vitro properties and on-farm observations. In order to gain more knowledge on this atypical lentivirus we investigated the in vivo tropism of Roccaverano strain in both, experimentally and naturally infected goats. Antibody responses were monitored as well as tissue distribution and viral load, evaluated by real time PCR on single spliced (gag/env) and multiple spliced (rev) RNA targets respectively, that were compared to histopathological lesions. Lymph nodes, spleen, alveolar macrophages and mammary gland turned out to be the main tissue reservoirs of genotype E1-provirus. Moreover, mammary gland and/or mammary lymph nodes acted as active replication sites in dairy goats, supporting the lactogenic transmission of this virus. Notably, a direct association between viral load and concomitant infection or inflammatory processes was evident within organs such as spleen, lung and testis. Our results validate the low pathogenicity designation of SRLV genotype E1 in vivo, and confirm the monocyte-macrophage cell lineage as the main virus reservoir of this genotype. Accordingly, SRLV genotype E displays a tropism towards all tissues characterized by an abundant presence of these cells, either for their own anatomical structure or for an occasional infectious/inflammatory status.This work was co-funded by the Italian Ministry of Instruction, University and Research PRIN 2008 (no. 20084CSFLT), by Piedmont Region, “Ricerca Sanitaria Finalizzata” 2008 and 2009, and by University of Turin, “Fondi ricerca locale (ex-60%)” 2009. The Authors acknowledge Mr. R. Maritano, CISRA for his valuable contribution in animal management, and Mr. D. Arnulfo and R. Vanni for their competent work and assistance during animal autopsies. R. Reina was supported by Spanish Ministry of Science and Innovation ‘Ramón y Cajal’ contract (AGL2013-49137-C3-1R).Peer reviewe

Critical flow prediction by system codes – Recent analyses made within the FONESYS network

A benchmark activity on Two-Phase Critical Flow (TPCF) prediction was conducted in the framework of the Forum & Network of System Thermal-Hydraulics Nuclear Reactor Thermal-Hydraulics (FONESYS). FONESYS is a network among code developers who share the common objective to strengthen current technology. The aim of the FONESYS Network is to highlight the capabilities and the robustness as well as the limitations of current SYSTH codes to predict the main phenomena during transient scenarios in nuclear reactors for safety issues. Six separate effect test facilities, more than 90 tests, both in steady and transient conditions, were considered for the activity. Moreover, two ideal tests were designed for code to code comparison in clearly defined conditions. Overall eight System Thermal-Hydraulic (SYS-TH) codes were adopted, mostly by the developers themselves, ensuring the minimization of the user effect. Results from selected tests were also compared against Delayed Equilibrium Model, not yet implemented in industrial version of SYS-TH codes. Generally, the results of the benchmark show an improvement of the capability of SYS-TH codes to predict TPCF in the last three decades. However, predicting break flowrate remains a major source of uncertainty in accidental transient simulations of Water-Cooled Nuclear Reactors (WCNR). A set of possible actions is proposed to go beyond the current limitations of choked flow models. More detailed guidelines for using 0-D choked flow models is possible by using the experience gained by the benchmark results as well as all available validation results. Progress in understanding and 1-D modelling of flashing and choked flow might be achieved by a deeper physical analysis leading to more mechanistic models based on specific flow regime maps for high speed flow. Also the use of advanced 3-D numerical tools may help to understand and predict the complex 3-D geometrical effect

Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study

<p>Abstract</p> <p>Background</p> <p>Increased serum levels of homocysteine and uric acid have each been associated with cardiovascular risk. We analyzed whether homocysteine and uric acid were associated with glomerular filtration rate (GFR) and albuminuria independently of each other. We also investigated the association of <it>MTHFR </it>polymorphisms related to homocysteine with albuminuria to get further insight into causality.</p> <p>Methods</p> <p>This was a cross-sectional population-based study in Caucasians (<it>n </it>= 5913). Hyperhomocysteinemia was defined as total serum homocysteine ≥ 15 μmol/L. Albuminuria was defined as urinary albumin-to-creatinine ratio > 30 mg/g.</p> <p>Results</p> <p>Uric acid was associated positively with homocysteine (r = 0.246 in men and r = 0.287 in women, <it>P </it>< 0.001). The prevalence of albuminuria increased across increasing homocysteine categories (from 6.4% to 17.3% in subjects with normal GFR and from 3.5% to 14.5% in those with reduced GFR, <it>P </it>for trend < 0.005). Hyperhomocysteinemia (OR = 2.22, 95% confidence interval: 1.60-3.08, <it>P </it>< 0.001) and elevated serum uric acid (OR = 1.27, 1.08-1.50, per 100 μmol/L, <it>P </it>= 0.004) were significantly associated with albuminuria, independently of hypertension and type 2 diabetes. The 2-fold higher risk of albuminuria associated with hyperhomocysteinemia was similar to the risk associated with hypertension or diabetes. <it>MTHFR </it>alleles related to higher homocysteine were associated with increased risk of albuminuria.</p> <p>Conclusions</p> <p>In the general adult population, elevated serum homocysteine and uric acid were associated with albuminuria independently of each other and of renal function.</p