1,511 research outputs found
Facilitating access to voluntary and community services for patients with psychosocial problems: a before-after evaluation
Background: Patients with psychosocial problems may benefit from a variety of community, educational, recreational and voluntary sector resources, but GPs often under-refer to these through lack of knowledge and time. This study evaluated the acceptability and effectiveness of graduate primary care mental health workers (GPCMHWs) facilitating access to voluntary and community sector services for patients with psychosocial problems. Methods: Patients with psychosocial problems from 13 general practices in London were referred to a GPCMHW Community Link scheme providing information and support to access voluntary and community resources. Patient satisfaction, mental health and social outcomes, and use of primary care resources, were evaluated. Results: 108 patients consented to take part in the study. At three-month follow-up, 63 (58%) had made contact with a community service identified as suitable for their needs. Most were satisfied with the help provided by the GPCMHW in identifying and supporting access to a suitable service. There was a reduction in the number of patients with a probable mental health problem on the GHQ-12 from 83% to 52% (difference 31% (95% CI, 17% – 44%). Social adjustment improved and frequencies of primary care consultations and of prescription of psychotropic medications were reduced. Conclusion: Graduates with limited training in mental health and no prior knowledge of local community resources can help patients with psychosocial problems access voluntary and community services, and patients value such a scheme. There was some evidence of effectiveness in reducing psychosocial and mental health problems
The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK.
The oncogenic fusion protein RET/PTC3 (RP3) that is expressed in papillary thyroid carcinoma (PTC) and thyroid epithelia in Hashimoto\u27s thyroiditis activates nuclear factor-kappa B (NF-κB) and induces pro-inflammatory gene expression; however, the mechanism of this activation is unknown. To address this, we expressed RP3 in murine embryonic fibroblasts (MEFs) lacking key classical and noncanonical NF-κB signaling components. In wild-type MEFs, RP3 upregulated CCL2, CXCL1, granulocyte-macrophage colony-stimulating factor and tumor necrosis factor expression and activated classical but not noncanonical NF-κB. RP3-activated NF-κB in IκB kinase (IKK)β(-/-) MEFs but not IKKα- or NF-κB essential modulator (NEMO)-deficient cells and activation was inhibited by a peptide that blocks NEMO binding to the IKKs. RP3 increased the levels of NF-κB-inducing kinase (NIK) and did not activate NF-κB in NIK-deficient MEFs. Notably, NIK stabilization was not accompanied by TRAF3 degradation demonstrating that RP3 disrupts normal basal NIK regulation. Dominant-negative NIK blocked RP3-induced NF-κB activation and an RP3 signaling mutant (RP3(Y588F)) did not stabilize NIK. Finally, examination of PTC specimens revealed strong positive staining for NIK. We therefore conclude that RP3 activates classical NF-κB via NIK, NEMO and IKKα. Importantly, our findings reveal a novel mechanism for oncogene-induced NF-κB activation via stabilization of NIK
The 69 ms Radio Pulsar Near the Supernova Remnant RCW 103
We report the detection of the radio pulsar counterpart to the 69 ms X-ray
pulsar discovered near the supernova remnant RCW 103 (G332.4-0.4). Our
detection confirms that the pulsations arise from a rotation-powered neutron
star, which we name PSR J1617-5055. The observed barycentric period derivative
confirms that the pulsar has a characteristic age of only 8 kyr, the sixth
smallest of all known pulsars. The unusual apparent youth of the pulsar and its
proximity to a young remnant requires that an association be considered.
Although the respective ages and distances are consistent within substantial
uncertainties, the large inferred pulsar transverse velocity is difficult to
explain given the observed pulsar velocity distribution, the absence of
evidence for a pulsar wind nebula, and the symmetry of the remnant. Rather, we
argue that the objects are likely superposed on the sky; this is reasonable
given the complex area. Without an association, the question of where is the
supernova remnant left behind following the birth of PSR J1617-5055 remains
open. We also discuss a possible association between PSR J1617-5055 and the
gamma-ray source 2CG 333+01. Though an association is energetically plausible,
it is unlikely given that EGRET did not detect 2CG 333+01.Comment: 18 pages, 2 encapsulated Postscript figures, uses AAS LaTeX style
files. Accepted for publication in The Astrophysical Journal Letter
Null Geodesics in Five Dimensional Manifolds
We analyze a class of 5D non-compact warped-product spaces characterized by
metrics that depend on the extra coordinate via a conformal factor. Our model
is closely related to the so-called canonical coordinate gauge of Mashhoon et
al. We confirm that if the 5D manifold in our model is Ricci-flat, then there
is an induced cosmological constant in the 4D sub-manifold. We derive the
general form of the 5D Killing vectors and relate them to the 4D Killing
vectors of the embedded spacetime. We then study the 5D null geodesic paths and
show that the 4D part of the motion can be timelike -- that is, massless
particles in 5D can be massive in 4D. We find that if the null trajectories are
affinely parameterized in 5D, then the particle is subject to an anomalous
acceleration or fifth force. However, this force may be removed by
reparameterization, which brings the correct definition of the proper time into
question. Physical properties of the geodesics -- such as rest mass variations
induced by a variable cosmological ``constant'', constants of the motion and 5D
time-dilation effects -- are discussed and are shown to be open to experimental
or observational investigation.Comment: 19 pages, REVTeX, in press in Gen. Rel. Gra
Typical equilibrium state of an embedded quantum system
We consider an arbitrary quantum system coupled non perturbatively to a large
arbitrary and fully quantum environment. In [G. Ithier and F. Benaych-Georges,
Phys. Rev. A 96, 012108 (2017)] the typicality of the dynamics of such an
embedded quantum system was established for several classes of random
interactions. In other words, the time evolution of its quantum state does not
depend on the microscopic details of the interaction. Focusing at the long time
regime, we use this property to calculate analytically a new partition function
characterizing the stationary state and involving the overlaps between
eigenvectors of a bare and a dressed Hamiltonian. This partition function
provides a new thermodynamical ensemble which includes the microcanonical and
canonical ensembles as particular cases. We check our predictions with
numerical simulations.Comment: 1 figure, 5 pages. This article supersedes the part on the
equilibrium state in arXiv:1510.0435
Identification of the Mass Donor Star's Spectrum in SS 433
We present spectroscopy of the microquasar SS 433 obtained near primary
eclipse and disk precessional phase Psi = 0.0, when the accretion disk is
expected to be most ``face-on''. The likelihood of observing the spectrum of
the mass donor is maximized at this combination of orbital and precessional
phases since the donor is in the foreground and above the extended disk
believed to be present in the system. The spectra were obtained over four
different runs centered on these special phases. The blue spectra show clear
evidence of absorption features consistent with a classification of A3-7 I. The
behavior of the observed lines indicates an origin in the mass donor. The
observed radial velocity variations are in anti-phase to the disk, the
absorption lines strengthen at mid-eclipse when the donor star is expected to
contribute its maximum percentage of the total flux, and the line widths are
consistent with lines created in an A supergiant photosphere. We discuss and
cast doubt on the possibility that these lines represent a shell spectrum
rather than the mass donor itself. We re-evaluate the mass ratio of the system
and derive masses of 10.9 +/- 3.1 Msun and 2.9 +/- 0.7 Msun for the mass donor
and compact object plus disk, respectively. We suggest that the compact object
is a low mass black hole.
In addition, we review the behavior of the observed emission lines from both
the disk/wind and high velocity jets.Comment: submitted to ApJ, 24 pages, 7 figure
Formation of a disk-structure and jets in the symbiotic prototype Z And during its 2006-2010 active phase
We present an analysis of spectrophotometric observations of the latest cycle
of activity of the symbiotic binary Z And from 2006 to 2010. We estimate the
temperature of the hot component of Z And to be \approx 150000 - 170000 K at
minimum brightness, decreasing to \approx 90000 K at the brightness maximum.
Our estimate of the electron density in the gaseous nebula is
N_{e}=10^{10}-10^{12} cm^{-3} in the region of formation of lines of neutral
helium and 10^6-10^7 cm^{-3} in the region of formation of the [OIII] and
[NeIII] nebular lines. A trend for the gas density derived from helium lines to
increase and the gas density derived from [OIII] and [NeIII] lines to
simultaneously decrease with increasing brightness of the system was observed.
Our estimates show that the ratios of the theoretical and observed fluxes in
the [OIII] and [NeIII] lines agree best when the O/Ne ratio is similar to its
value for planetary nebulae. The model spectral energy distribution showed
that, in addition to a cool component and gaseous nebula, a relatively cool
pseudophotosphere (5250-11 500 K) is present in the system. The simultaneous
presence of a relatively cool pseudophotosphere and high-ionization spectral
lines is probably related to a disk-like structure of the pseudophotosphere.
The pseudophotosphere formed very rapidly, over several weeks, during a period
of increasing brightness of Z And. We infer that in 2009, as in 2006, the
activity of the system was accompanied by a collimated bipolar ejection of
matter. In contrast to the situation in 2006, the jets were detected even
before the system reached its maximum brightness. Moreover, components with
velocities close to 1200 km/s disappeared at the maximum, while those with
velocities close to 1800 km/s appeared.Comment: 18 pages, 19 figures, Accepted for publication in Astronomy Report
Pattern of Disease after Murine Hepatitis Virus Strain 3 Infection Correlates with Macrophage Activation and Not Viral Replication
Murine hepatitis virus strain (MHV-3) produces a strain-dependent pattern of disease which has been used as a model for fulminant viral hepatitis. This study was undertaken to examine whether there was a correlation between macrophage activation and susceptibility or resistance to MHV-3 infection. Peritoneal macrophages were isolated from resistant A/J and susceptible BALB/cJ mice and, following stimulation with MHV-3 or lipopolysaccharide (LPS), analyzed for transcription of mRNA and production of interleukin-1 (IL-1), tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), mouse fibrinogen-like protein (musfiblp), tissue factor (TF), leukotriene B4, and prostaglandin E2 (PGE2). Macrophages from BALB/cJ mice produced greater amounts of IL-1, TNF-alpha, TGF-beta, leukotriene B4, and musfiblp following MHV-3 infection than macrophages from resistant A/J mice, whereas in response to LPS, equivalent amounts of IL-1, TNF-alpha, TGF-beta, and TF were produced by macrophages from both strains of mice. Levels of mRNA of IL-1, TNF-alpha, and musfiblp were greater and more persistent in BALB/cJ than in A/J macrophages, whereas the levels and kinetics of IL-1, TNF-alpha, and TF mRNA following LPS stimulation were identical in macrophages from both strains of mice. Levels of production of PGE2 by MHV-3-stimulated macrophages from resistant and susceptible mice were equivalent; however, the time course for induction of PGE2, differed, but the total quantity of PGE2 produced was insufficient to inhibit induction of musfiblp, a procoagulant known to correlate with development of fulminant hepatic necrosis in susceptible mice. These results demonstrate marked differences in production of inflammatory mediators to MHV-3 infection in macrophages from resistant A/J and susceptible BALB/cJ mice, which may explain the marked hepatic necrosis and fibrin deposition and account for the lethality of MHV-3 in susceptible mice
Recommended from our members
Corrosion of structural materials by lead-based reactor coolants.
Advanced nuclear reactor design has, in recent years, focused increasingly on the use of heavy-liquid-metal coolants, such as lead and lead-bismuth eutectic. Similarly, programs on accelerator-based transmutation systems have also considered the use of such coolants. Russian experience with heavy-metal coolants for nuclear reactors has lent credence to the validity of this approach. Of significant concern is the compatibility of structural materials with these coolants. We have used a thermal convection-based test method to allow exposure of candidate materials to molten lead and lead-bismuth flowing under a temperature gradient. The gradient was deemed essential in evaluating the behavior of the test materials in that should preferential dissolution of components of the test material occur we would expect dissolution in the hotter regions and deposition in the colder regions, thus promoting material transport. Results from the interactions of a Si-rich mild steel alloy, AISI S5, and a ferritic-martensitic stainless steel, HT-9, with the molten lead-bismuth are presented
- …