Sediment-hosted gas hydrates : new insights on natural and synthetic systems

In the public's imagination, hydrates are seen as either a potential new source of energy to be exploited as the world uses up its reserves of oil and gas or as a major environmental hazard. Scientists, however, have expressed great uncertainty as to the global volume of hydrates and have reached little agreement on how they might be exploited. Both of these uncertainties can be reduced by a better understanding of how hydrates are held within sediments. There are conflicting ideas as to whether hydrates are disseminated within selected lithologies or trapped within fractures comparable to mineral lodes. To resolve this, hydrates have to be examined at all scales ranging from using seismics to microscopic studies. Their position within sediments also influences the stability of methane hydrate in responding to pressure and temperature and how the released gas might transfer to the ocean, atmosphere, or to a transport mechanism for recovery. These results also run parallel with the studies of carbon dioxide hydrate, which is being considered as a potential sequestion medium

Mapping hydrate stability zones offshore Scotland

One practical method to reduce environmentally damaging greenhouse gas emissions is through the geological storage of carbon dioxide. Deep, warm storage of carbon dioxide is currently taking place at Sleipner, North Sea and Weyburn, Canada. It is, however, also possible to store carbon dioxide as a liquid and hydrate in cool, sub-seabed sediments. Offshore north and west of Scotland seafloor pressures and temperatures are suitable for hydrate formation. In addition to the possibility of natural methane hydrate being present in this region, conditions may also be favourable for carbon dioxide storage as a liquid and hydrate. A computer program has been developed to calculate the depth to the base of the carbon dioxide and methane hydrate stability zones in two offshore regions: the Faeroe–Shetland Channel and the northern Rockall Trough. Results predict that methane hydrate remains stable to a maximum depth of 650 m below the seabed in the Faeroe–Shetland Channel, and 600 m below the seabed in the northern Rockall Trough; the carbon dioxide hydrate stability zone extends below the seabed to a depth of 345 and 280 m, respectively. No physical evidence for the existence of natural hydrate in these regions has been confirmed. Suitable conditions for carbon dioxide storage as a liquid and hydrate exist, and should this storage method be developed further, a more refined program and greater offshore investigations to improve data sets would be necessary to scope the full potential

Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?

A depletion of natural killer (hTK) cells seems to play a role in the course of systemic lupus erythematosus (SLE) whereas the possible involvement in this disease of T cell receptor (TCR) gamma/delta positive T cells is still debated. The aim of this study was to evaluate the peripheral blood mononuclear cells (PBMCs) that express NK surface markers CD16 and CD56 or gamma/delta TCR antigen in 58 SLE patients, investigating the possible role of these cell subsets involved in non-MHC-restricted cytotoxicity and their relationship with the main clinical and laboratory parameters. SLE patients had, with respect to controls, considerably decreased values of NK cells (P < 0.0004 in percentage and P < 0.00004 as absolute number), of non-MHC-restricted T cytotoxic lymphocytes (P < 0.007 and P < 0.0015, respectively) and of T cells expressing gamma/delta TCR (P < 0.02 and P < 0.004, respectively). The absolute numbers of these cell subsets positively correlated to each other (P < 0.009). gamma/delta T cells inversely correlated with higher ESR values, both percentually (P < 0.006; r = -0.367) and in absolute number (P < 0.009; r = -0.350). Moreover, the percentage values of this cell subset inversely correlated with higher levels of CRP (P < 0.05; r = -0.256) while SLE patients with anti-SSB/La antibodies had lower values of T lymphocytes bearing gamma/delta TCR, both as percentage (P < 0.008) and as absolute number (P < 0.02). Our study indicates that non-MHC-restricted cytotoxicity, shared by NK, NK-like and gamma/delta T cells, may be down-regulated in SLE patients, owing to a significant reduction of these PBMC subsets. These specific cell subset impairments seem to affect only some aspects of the disease, suggesting a weakening of the regulatory properties of these cells in the control of different immunological and inflammatory features of SLE, that could be of importance in its clinical expression