Composite nanoclay-hydroxyapatite-polymer fiber scaffolds for bone tissue engineering manufactured using pressurized gyration

A novel fabrication of polymer composite fibers using polycaprolactone (PCL), montmorillonite nanoclay (MMT-Clay), and nano-hydroxyapatite-clay (HAP MMT-Clay) is reported for bone tissue engineering applications. Using a pressurized gyration (PG) setup, polycaprolactone (PCL) fibers incorporated with in situ mineralized HAP MMT-Clay and MMT-Clay were investigated. Using the novel fabrication method, we were able to successfully manufacture HAP-nanoclay-PCL fibers. Further, 3D scaffolds made using the prepared fibers were able to enhance bone growth, cell viability, and proliferation. The results demonstrated that the polymer fiber scaffolds are biocompatible, and the cells were able to thrive and differentiate on the fiber scaffolds. A significant increase in cell viability, osteogenic differentiation, ECM formation, and collagen formation was observed with PCL HAP MMT-Clay fibers scaffolds compared to the behaviors in PCL fibers. Further, the intracellular ALP levels increased with PCL HAP MMT-Clay fiber scaffold, indicating enhanced osteogenic differentiation of MSCs. This work shows a promising outlook for the future of manufacturable composite nanoclay polymer fibers incorporated as scaffolds for bone tissue engineering applications

All Sky Survey Mission Observing Scenario Strategy

This paper develops a general observing strategy for missions performing all-sky surveys, where a single spacecraft maps the celestial sphere subject to realistic constraints. The strategy is flexible such that targeted observations and variable coverage requirements can be achieved. This paper focuses on missions operating in Low Earth Orbit, where the thermal and stray-light constraints due to the Sun, Earth, and Moon result in interacting and dynamic constraints. The approach is applicable to broader mission classes, such as those that operate in different orbits or that survey the Earth. First, the instrument and spacecraft configuration is optimized to enable visibility of the targeted observations throughout the year. Second, a constraint-based high-level strategy is presented for scheduling throughout the year subject to a simplified subset of the constraints. Third, a heuristic-based scheduling algorithm is developed to assign the all-sky observations over short planning horizons. The constraint-based approach guarantees solution feasibility. The approach is applied to the proposed SPHEREx mission, which includes coverage of the North and South Celestial Poles, Galactic plane, and a uniform coverage all-sky survey, and the ability to achieve science requirements demonstrated and visualized. Visualizations demonstrate the how the all-sky survey achieves its objectives

Impingement of coaxial jet on convex element for confined and unconfined flow

Jet impingement is most effective and active method for cooling and heating of any surface or system. The ability of jet impingement is greatly influenced by nozzle configuration and other dimensional and non-dimensional parameters. Impinging coaxial swirl jet generates interesting flow filed on any test surface and influences both pressure and heat distribution on impinging surfaces. In present study, an experimental investigation is carried to analyze the effects of turbulent coaxial swirl jet on the pressure distribution (PC & PCO) on convex element. For better and acceptable results, the desirable parameters are identified from previous research works. The present experimental result highlights the independency of pressure coefficient (PC) for jet-Reynolds number (Re=70000 to 45000), effect of circumferential angle (θ) or inclination of test element, effect of jet exit to test element distance (Z/dh) and effect of confinement on PC & PCO pattern on a convex test element. The higher pressure coefficient value are obtained at lower Z/dh = 1 & at θ = 15° to 12°and significant drop in the values are seen with increase in the Z/dh & θ. At θ = 20° to 30° the value of PC & PCO reaches to negative magnitude. The use of confinement tube enhancementthe pressure distribution (PC & PCO) by 61% to 64% is seen for the same flow conditions

An approach to Kaarya Karana Vaada in context to Prakruti Sama Samveta and Vikruti Vishama Samvetha

Ayurveda is an ancient science based on different schools of philosophies. As it is an applied science so it has the scientific background. The fundamental principles of Ayurveda are laid down after undergoing experimentation from time to time. This is the reason that these principles are still applicable and holds good even in present era. One such basic principle is Kaarya Karana Vaada (cause and effect theory). Kaarya Karana Vaada consists of two basic philosophy, Satkaaryavaada (theory of existence) and Asatkaaryavaada (theory of non existence). The principles of diagnosis and management of disease according to Ayurveda is based on this Kaarya Karana sidhantha. It helps in understanding the concepts of prakruti Sama Samavetha and vikruti Vishama Samavetha , the two principles explained in Ayurveda to understand the concept of diagnosis , treatment and health management