APTAMER: A REVIEW ON IT’S IN VITRO SELECTION AND DRUG DELIVERY SYSTEM

In recent year, Aptamer has been one of the key tools in the field of advanced drug delivery systems. Aptamer are oligonucleotides or peptides that bind to a specific target molecule. In this review we summarize the major differences between the antibody and an Aptamer along with the different methodology of the In vitro selection of the Aptamer by using SELEX (Systematic evolution of ligands by exponential enrichment) technique. SELEX is a technique which has a based biosensor and some of the novel drug delivery system. The article referred in this review was referred from the above said source was in the range of 1990-2020 y. Primary contents is searched from science direct, springer nature, scopus indexed journals. The resources are downloaded from google scholar, peer-reviewed published literature from scientific journals and books

Tractography passes the test: Results from the diffusion-simulated connectivity (disco) challenge.

Estimating structural connectivity from diffusion-weighted magnetic resonance imaging is a challenging task, partly due to the presence of false-positive connections and the misestimation of connection weights. Building on previous efforts, the MICCAI-CDMRI Diffusion-Simulated Connectivity (DiSCo) challenge was carried out to evaluate state-of-the-art connectivity methods using novel large-scale numerical phantoms. The diffusion signal for the phantoms was obtained from Monte Carlo simulations. The results of the challenge suggest that methods selected by the 14 teams participating in the challenge can provide high correlations between estimated and ground-truth connectivity weights, in complex numerical environments. Additionally, the methods used by the participating teams were able to accurately identify the binary connectivity of the numerical dataset. However, specific false positive and false negative connections were consistently estimated across all methods. Although the challenge dataset doesn't capture the complexity of a real brain, it provided unique data with known macrostructure and microstructure ground-truth properties to facilitate the development of connectivity estimation methods

Bridging the Information Divide among Engineering College Libraries in Tamil Nadu, India: A Network Design

The pattern of engineering education and research is changing in response to new methods, techniques, and applications of technology. Engineering colleges are in constant need of information about developments in science and technology. In today\u27s environment, it is impossible for any library to stand alone. No library can singlehandedly obtain all the material that is needed or requested. Engineering libraries must share resources and organize cooperative services. Advances in information technology offer methods of networking and resource sharing among the geographically dispersed and remotely located library and information centres. This paper discusses ways that engineering colleges can share resources in the networked information environment, as well as proposing a network design called Tamil Nadu Engineering College Libraries Network (TECLIBNET)

Optimal sizing and cost analysis of hybrid power system for a stand-alone application in Coimbatore region: a case study

This paper presents the optimal sizing of PV/Wind/Fuel Cell/Battery Hybrid Energy System for energizing a Small Scale Industrial Application or a village domestic load of 200 kW. HOMER software is used for simulation of the complete system. The solar radiation data and wind speed data used in this paper are for the place of Coimbatore, Tamil Nadu, India which is located 11.0183° N longitude and 76.9725° E latitude. The optimized sizes of components of Hybrid Power System (HPS) are found based on Levelised Cost of Energy (LCE) and total Net Present Cost (NPC). The results are presented and compared for five different combinations of HPS components. Suggestions are also presented to choose the low cost system which produces energy at low LCE

Power Quality Improvement by Direct Power Control of Active Front End Rectifier

339-342Active fronts End Rectifiers (AFE) are used as a powerful tool for Harmonic Mitigation. This paper proposes a new development of Direct Power Control (DPC) in AFE Rectifier technologies that are utilized to mitigate harmonics in utility power lines. In this paper, Voltage Oriented Control (VOC) based Direct Power control (DPC) of three phases PWM Rectifier with reduced input harmonics and improved power factor is presented. In the proposed Direct Power Control based on Voltage Oriented Control scheme, instantaneous active and reactive powers provided by harmonic component of input currents are directly controlled using predefined switching table with 12 switching states. A complete simulation model is developed using MATLAB/Simulink in order to test the performance of VOC based DPC of PWM rectifier and compared with SVPWM based AFE Rectifier. Results show effective harmonic compensation at front end for DPC based PWM rectifier and the current THD is 3.3% which is well below the IEEE standards. Also almost unity power factor is achieved with significant power ripple reduction and more sinusoidal grid current can be observed in DPC