797 research outputs found
Model Order Reduction for Rotating Electrical Machines
The simulation of electric rotating machines is both computationally
expensive and memory intensive. To overcome these costs, model order reduction
techniques can be applied. The focus of this contribution is especially on
machines that contain non-symmetric components. These are usually introduced
during the mass production process and are modeled by small perturbations in
the geometry (e.g., eccentricity) or the material parameters. While model order
reduction for symmetric machines is clear and does not need special treatment,
the non-symmetric setting adds additional challenges. An adaptive strategy
based on proper orthogonal decomposition is developed to overcome these
difficulties. Equipped with an a posteriori error estimator the obtained
solution is certified. Numerical examples are presented to demonstrate the
effectiveness of the proposed method
The f_LT Response Function of D(e,e'p)n at Q^2=0.33(GeV/c)^2
The interference response function f_LT (R_LT) of the D(e,e'p)n reaction has
been determined at squared four-momentum transfer Q^2 = 0.33 (GeV/c)^2 and for
missing momenta up to p_miss= 0.29 (GeV/c). The results have been compared to
calculations that reproduce f_LT quite well but overestimate the cross sections
by 10 - 20% for missing momenta between 0.1 (GeV/c) and 0.2 (GeV/c) .Comment: 12 Pages, 10 figure
Consistent alpha-cluster description of the 12C (0^+_2) resonance
The near-threshold 12C (0^+_2) resonance provides unique possibility for fast
helium burning in stars, as predicted by Hoyle to explain the observed
abundance of elements in the Universe. Properties of this resonance are
calculated within the framework of the alpha-cluster model whose two-body and
three-body effective potentials are tuned to describe the alpha - alpha
scattering data, the energies of the 0^+_1 and 0^+_2 states, and the
0^+_1-state root-mean-square radius. The extremely small width of the 0^+_2
state, the 0_2^+ to 0_1^+ monopole transition matrix element, and transition
radius are found in remarkable agreement with the experimental data. The
0^+_2-state structure is described as a system of three alpha-particles
oscillating between the ground-state-like configuration and the elongated chain
configuration whose probability exceeds 0.9
Indications for the Nonexistence of Three-Neutron Resonances near the Physical Region
The pending question of the existence of three-neutron resonances near the
physical energy region is reconsidered. Finite rank neutron-neutron forces are
used in Faddeev equations, which are analytically continued into the unphysical
energy sheet below the positive real energy axis. The trajectories of the
three-neutron S-matrix poles in the states of total angular momenta and parity
J^\pi=1/2 +- and J^\pi= 3/2 +- are traced out as a function of artificial
enhancement factors of the neutron-neutron forces. The final positions of the
S-matrix poles removing the artificial factors are found in all cases to be far
away from the positive real energy axis, which provides a strong indication for
the nonexistence of nearby three-neutron resonances. The pole trajectories
close to the threshold E=0 are also predicted out of auxiliary generated
three-neutron bound state energies using the Pad\'e method and agree very well
with the directly calculated ones.Comment: 20 pages, 7 Postscript figures, fig.1 is corrected, uses relax.st
Measurement of Rlt and Atl in the 4He(e,e'p)3H Reaction at pmiss of 130-300 MeV/c
We have measured the 4He(e,e'p)3H reaction at missing momenta of 130-300
MeV/c using the three-spectrometer facility at the Mainz microtron MAMI. Data
were taken in perpendicular kinematics to allow us to determine the response
function Rlt and the asymmetry term Atl. The data are compared to both
relativistic and non-relativistic calculations.Comment: To be published in the European Physical Journal
High-precision Studies of the He(e,ep) Reaction at the Quasielastic Peak
Precision studies of the reaction He(e,ep) using the
three-spectrometer facility at the Mainz microtron MAMI are presented. All data
are for quasielastic kinematics at MeV/c. Absolute cross
sections were measured at three electron kinematics. For the measured missing
momenta range from 10 to 165 MeV/c, no strength is observed for missing
energies higher than 20 MeV. Distorted momentum distributions were extracted
for the two-body breakup and the continuum. The longitudinal and transverse
behavior was studied by measuring the cross section for three photon
polarizations. The longitudinal and transverse nature of the cross sections is
well described by a currently accepted and widely used prescription of the
off-shell electron-nucleon cross-section. The results are compared to modern
three-body calculations and to previous data.Comment: 4 pages, 3 figures. Submitted for publication in Phys. Rev. Let
What factors influence training opportunities for older workers? Three factorial surveys exploring the attitudes of HR professionals
The core research questions addressed in this paper are: what factors influence HR professionals in deciding whether to approve training proposals for older workers? What kind of training are they more likely to recommend for older employees and in which organizational contexts? We administered three factorial surveys to 66 HR professionals in Italy. Participants made specific training decisions based on profiles of hypothetical older workers. Multilevel analyses indicated that access to training decreases strongly with age, while highly-skilled older employees with low absenteeism rates are more likely to enjoy training opportunities. In addition, older workers displaying positive performance are more likely to receive training than older workers who perform poorly, suggesting that training late in working life may serve as a reward for good performance rather than as a means of enhancing productivity. The older the HR professional evaluating training proposals, the higher the probability that older workers will be recommended for training.
keywords: training; older workers; HR professionals; factorial survey; multilevel model
Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma
Background: The approval of immune checkpoint inhibitors in combination with specific diagnostic biomarkers presents new challenges to pathologists as tumor tissue needs to be tested for expression of programmed death-ligand 1 (PD-L1) for a variety of indications. As there is currently no requirement to use companion diagnostic assays for PD-L1 testing in Germany different clones are used in daily routine. While the correlation of staining results has been tested in various entities, there is no data for head and neck squamous cell carcinomas (HNSCC) so far.
Methods: We tested five different PD-L1 clones (SP263, SP142, E1L3N, 22-8, 22C3) on primary HNSCC tumor tissue of 75 patients in the form of tissue microarrays. Stainings of both immune and tumor cells were then assessed and quantified by pathologists to simulate real-world routine diagnostics. The results were analyzed descriptively and the resulting staining pattern across patients was further investigated by principal component analysis and non-negative matrix factorization clustering.
Results: Percentages of positive immune and tumor cells varied greatly. Both the resulting combined positive score as well as the eligibility for certain checkpoint inhibitor regimens was therefore strongly dependent on the choice of the antibody. No relevant co-clustering and low similarity of relative staining patterns across patients was found for the different antibodies.
Conclusions: Performance of different diagnostic anti PD-L1 antibody clones in HNSCC is less robust and interchangeable compared to reported data from other tumor entities. Determination of PD-L1 expression is critical for therapeutic decision making and may be aided by back-to-back testing of different PD-L1 clones
- …