Parametric resonance of a two-dimensional electron gas under bichromatic irradiation

In an ultrahigh mobility 2D electron gas, even a weak nonparabolicity of the electron dispersion, by violating Kohn's theorem, can have a drastic effect on dc magnetotransport under ac drive. We study theoretically the manifestation of this effect in the dc response to the combined action of two driving ac-fields (bichromatic irradiation). Compared to the case of monochromatic irradiation, which is currently intensively studied both experimentally and theoretically, the presence of a second microwave source provides additional insight into the properties of an ac-driven 2D electron gas. In particular, we find that nonparabolicity, being the simplest cause for a violation of Kohn's theorem, gives rise to new qualitative effects specific to bichromatic irradiation. Namely, when the frequencies $\omega_1$ and $\omega_2$ are well away from the cyclotron frequency, $\omega_c$, our simple classical considerations demonstrate that the system becomes parametrically unstable with respect to fluctuations with frequency $(\omega_1+\omega_2)/2$. As an additional effect of nonparabolicity, this parametric instability can manifest itself in the dc properties of the system. This happens when $\omega_1$, $\omega_2$ and $\omega_c$ are related as 3:1:2, respectively. Even for weak detuning between $\omega_1$ and $\omega_2$, the effect of the bichromatic irradiation on the dc response in the presence of nonparabolicity can differ dramatically from the monochromatic case. In particular, the equations of motion can acquire multistable solutions. As a result, the diagonal dc-conductivity can assume several stable negative values at the same magnetic field.Comment: 11 pages, 10 figure

Preparation and Crystal Structure of Diaqua(μ-5,5'-bistetrazolato-κ4N1,N2,N5,N6)copper(II)

The crystal structure of the coordination polymer diaqua(μ-5,5'-bistetrazolato-κ4N1,N2,N5,N6)copper(II) was determined by X-ray diffraction. The copper atoms are connected to chains over the bridging 5,5'-bistetrazolato ligand. The energetic properties of the compound were investigated, such as thermal behavior and sensitivities (shock, friction, electrical spark)

An exploratory case study on the perceived effectiveness of co-teaching and a need for professional development

Co-teaching is an instructional method used to educate many special education and at-risk youth. This study explored the perceived knowledge of and effectiveness with co-teaching through the perceptions of co-teachers and administrators at a large suburban high school. This study also explored the perceived effectiveness of co-teachers in Gately & Gately\u27s eight components of effective co-teaching (2001). Four dyads completed the Co-teaching Rating Scale and a questionnaire. They also engaged in classroom observations and a focus group. Data from these data sources along with a focus group that included administrators from the high school generated a picture of co-teaching and of the co-teacher perceptions of their effectiveness. This study explored the perceptions of co-teaching through co-teachers and administrators and challenges co-teachers perceive as barriers to their effectiveness. This case study resulted in recommendations to improve co-teaching practices

Geometric characterization of nodal domains: the area-to-perimeter ratio

In an attempt to characterize the distribution of forms and shapes of nodal domains in wave functions, we define a geometric parameter - the ratio $\rho$ between the area of a domain and its perimeter, measured in units of the wavelength $1/\sqrt{E}$. We show that the distribution function $P(\rho)$ can distinguish between domains in which the classical dynamics is regular or chaotic. For separable surfaces, we compute the limiting distribution, and show that it is supported by an interval, which is independent of the properties of the surface. In systems which are chaotic, or in random-waves, the area-to-perimeter distribution has substantially different features which we study numerically. We compare the features of the distribution for chaotic wave functions with the predictions of the percolation model to find agreement, but only for nodal domains which are big with respect to the wavelength scale. This work is also closely related to, and provides a new point of view on isoperimetric inequalities.Comment: 22 pages, 11 figure

The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells

BACKGROUND: Dendritic cells (DC) are the most potent antigen-presenting cells (APC) with the unique ability to activate naïve T cells and to initiate and maintain primary immune responses. Immunosuppressive and anti-inflammatory stimuli on DC such as the cytokine IL-10 suppress the activity of the transcription factor NF-κB what results in downregulation of costimulatory molecules, MHC and cytokine production. Glycoprotein NMB (GPNMB) is a transmembrane protein, which acts as a coinhibitory molecule strongly inhibiting T cell responses if present on APC. Interestingly, its expression on human monocyte-derived dendritic cells (moDC) is dramatically upregulated upon treatment with IL-10 but also by the BCR-ABL tyrosine kinase inhibitors (TKI) imatinib, nilotinib or dasatinib used for the treatment of chronic myeloid leukemia (CML). However, the molecular mechanisms responsible for GPNMB overexpression are yet unknown. RESULTS: The immunosuppressive cytokine IL-10 and the BCR-ABL TKI imatinib or nilotinib, that were examined here, concordantly inhibit the PI3K/Akt signaling pathway, thereby activating the downstream serine/threonine protein kinase GSK3ß, and subsequently the microphthalmia-associated transcription factor (MITF) that is phosphorylated and translocated into the nucleus. Treatment of moDC with a small molecule inhibitor of MITF activity reduced the expression of GPNMB at the level of mRNA and protein, indicating that GPNMB expression is in fact facilitated by MITF activation. In line with these findings, PI3K/Akt inhibition was found to result in GPNMB overexpression accompanied by reduced stimulatory capacity of moDC in mixed lymphocyte reactions (MLR) with allogeneic T cells that could be restored by addition of the GPNMB T cell ligand syndecan-4 (SD-4). CONCLUSIONS: In summary, imatinib, nilotinib or IL-10 congruently inhibit the PI3K/Akt signaling pathway thereby activating MITF in moDC, resulting in a tolerogenic phenotype. These findings extend current knowledge on the molecular mechanisms balancing activating and inhibitory signals in human DC and may facilitate the targeted manipulation of T cell responses in the context of DC-based immunotherapeutic interventions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12964-015-0099-5) contains supplementary material, which is available to authorized users

Paradox as invitation to act in problematic change situations

It has been argued that organizational life typically contains paradoxical situations such as efforts to manage change which nonetheless seem to reinforce inertia. Four logical options for coping with paradox have been explicated, three of which seek resolution and one of which ‘keeps the paradox open’. The purpose of this article is to explore the potential for managerial action where the paradox is held open through the use of theory on ‘serious playfulness’. Our argument is that paradoxes, as intrinsic features in organizational life, cannot always be resolved through cognitive processes. What may be possible, however, is that such paradoxes are transformed, or ‘moved on’ through action and as a result the overall change effort need not be stalled by the existence of embedded paradoxes

Expanding the reflexive space: resilient young adults, institutional cultures, and cognitive schemas

For many U.S. young adults, being resilient to stressful events hinges on making meaning of such events and thereby minimizing their negative emotional impact. Yet why are some better able to do this than others? In this study, which uses an innovative outlier sampling strategy and linked survey and interview data, we argue that one important factor is connection to institutional cultures associated with higher education, religion/spirituality, and the military. Such cultures provide material for the development of cognitive schemas that can be adopted and applied to their stressful experiences, which include narratives of social progress, divine providence, and self‐discipline. Using a metaphor adapted from the pragmatist philosopher Charles Sanders Peirce, we argue the resulting schemas have the effect of “expanding the space” of reflexive thought, providing new cognitive material for interpreting stress and supporting resilience. Finally, we argue this framing improves in several ways on the concept of meaning making often used in stress process research.Accepted manuscrip

Application of BRED technology to construct recombinant D29 reporter phage expressing EGFP

Bacteriophage Recombineering of Electroporated DNA (BRED) has been described for construction of gene deletion and point mutations in mycobacteriophages. Using BRED, we inserted a Phsp60-egfp cassette (1143 bp) into the mycobacteriophage D29 genome to construct a new reporter phage, which was used for detection of mycobacterial cells. The cassette was successfully inserted and recombinant mycobacteriophage purified. DNA sequencing of the cassette did not show any mutations even after several phage generations. Mycobacterium smegmatis mc2155 cells were infected with D29::Phsp60-egfp (MOI of 10) and evaluated for EGFP expression by microscopy. Fluorescence was observed at around 2 h after infection, but dissipated in later times because of cell lysis. We attempted to construct a lysis-defective mutant by deleting the lysA gene, although we were unable to purify the mutant to homogeneity even with complementation. These observations demonstrate the ability of BRED to insert c. 1 kbp-sized DNA segments into mycobacteriophage genomes as a strategy for constructing new diagnostic reporter phages.Fil: Silva, Joas L. da. Universidade de Sao Paulo; BrasilFil: Piuri, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Broussard, Gregory. University Of Pittsburgh; Estados UnidosFil: Marinelli, Laura J.. University Of Pittsburgh; Estados UnidosFil: Bastos, Gisele M.. Universidade de Sao Paulo; BrasilFil: Hirata, Rosario D. C.. Universidade de Sao Paulo; BrasilFil: Hatfull, Graham F.. University Of Pittsburgh; Estados UnidosFil: Hirata, Mario H.. Universidade de Sao Paulo; Brasi

Dominant cognitive frames and the innovative power of social networks

In this paper, we illustrate the link between social network structures, dominant cognitive frames on network purpose and the innovative power of a network, through a mixed-method comparative analysis of two Knowledge Translation Networks (KTNs)in the English National Health Service (NHS). Our findings illustrate several challenges for networked forms of organization linked to different manifestations of social networks (centralized/decentralized) and dominant cognitive frames (polarizing/loosely clustered). Our paper contributes a better understanding of how dominant frames on network purpose emerge alongside the development of network structure itself, and explores how this interplay between dominant frames and social networks impacts upon the collaborative work that supports the networks’ innovative power