161 research outputs found
Quinoxaline-Based Inhibitors of Malarial Protease Pfsub1
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure-activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1
Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary structure-activity relationship to create in silico models for binding of these compounds into the active site of PfSUB1
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