Recommended reference figures for geophysics and geodesy

Specific reference figures are recommended for consistent use in geophysics and geodesy. The selection of appropriate reference figure for geophysical studies suggests a relationship between the Antarctic negative gravity anomaly and the great shrinkage of the Antarctic ice cap about 4-5 million years ago. The depression of the south polar regions relative to the north polar regions makes the Southern Hemisphere flatter than the Northern Hemisphere, thus producing the third harmonic (pear-shaped) contribution to the earth's figure

Submm-bright X-ray absorbed QSOs at z~2: insights into the co-evolution of AGN and star-formation

We have assembled a sample of 5 X-ray-absorbed and submm-luminous type 1 QSOs at $z \sim 2$ which are simultaneously growing their central black holes through accretion and forming stars copiously. We present here the analysis of their rest-frame UV to submm Spectral Energy Distributions (SEDs), including new Herschel data. Both AGN (direct and reprocessed) and Star Formation (SF) emission are needed to model their SEDs. From the SEDs and their UV-optical spectra we have estimated the masses of their black holes $M_{BH}\sim 10^{9}-10^{10}\,M_{\odot}$, their intrinsic AGN bolometric luminosities $L_{BOL}\sim(0.8 - 20)\times 10^{13} L_{\odot}$, Eddington ratios $L_{BOL}/L_{Edd}\sim 0.1 - 1.1$ and bolometric corrections $L_{BOL}/L_{X,2-10}\sim 30 - 500$. These values are common among optically and X-ray-selected type 1 QSOs (except for RX~J1249), except for the bolometric corrections, which are higher. These objects show very high far-infrared luminosities $L_{FIR}\sim$ (2 - 8)$\times10^{12}\,M_{\odot}$ and Star Formation Rates SFR$\sim 1000 M_{\odot}/$y. From their $L_{FIR}$ and the shape of their FIR-submm emission we have estimated star-forming dust masses of $M_{DUST}\sim 10^9\,M_\odot$. We have found evidence of a tentative correlation between the gas column densities of the ionized absorbers detected in X-ray (N$_{H_{ion}}$) and $SFR$. Our computed black hole masses are amongst the most massive known.Comment: Accepted for publication in MNRAS, December 22, 2014, 17 pages, 5 figure

Social Profile Of The Aged In An Urban Population

Research Problem: What is the socio-demographic profile of urban aged population in Aligarh city. Objectives: i) To describe the socio-demographic profile of the aged population in an urban area, ii) To describe the attitude of these people. Design:Cross-sectional study. Setting : Urban areas of Aligarh city. Participants : 3951 persons aged 60 years and above Study Variables: Socio-demographic characteristics, attitudes. Statistical Analysis : By proportions. Result: 15% of the total  stimated elderly population covering all 10 sectors of Aligarh city was studied. The majority ofthe elderly (72.4%) belonged to 60-70 years age group. Most of them (77.2%) were illiterate, 61.6% belonged to lower socio-economic classes (IV & V), 78.1 % lived in joint families. 39.6% of the aged felt that they were not being given due respect by family members. Nearly half of them had an indifferent or unhappy attitude towards life. Conclusion: The socio-demographic characteristics of the aged are important and must be kept in mind for developing programs to assist them in living as respectful senior citizens

Isolation of Acanthamoeba isolates belonging to T2, T3, T4 and T7 genotypes from environmental samples in Ankara, Turkey

Acanthamoeba keratitis is a blinding infection that is becoming increasingly important in human health. Early diagnosis is a prerequisite for successful treatment and requires identification of Acanthamoeba at the genotypic level. The genus Acanthamoeba consists of both pathogenic and non-pathogenic species and has been recently classified into 13 different genotypes, T1-T12 and T14. More importantly, 95% of Acanthamoeba isolates that produce keratitis belong to T4 genotypes. In this study, we attempted to determine whether predominance of T4 isolates in Acanthamoeba keratitis is due to greater virulence or greater prevalence. We isolated 18 Acanthamoeba isolates from environmental samples in Ankara, Turkey and determined their pathogenic potential by means osmotolerance, temperature tolerance and in vitro cytotoxicity assays using corneal epithelial cells. Ribosomal DNA sequencing revealed that 10 isolates belong to T2, 5 belong to T3, 2 belong to T4 and one belongs to T7 genotype. As expected, T3 and T4 isolates exhibited the most pathogenic traits and were osmotolerant, temperature tolerant and exhibited severe corneal epithelial cell cytotoxicity indicating their pathogenic potential. Overall these data indicate that high frequency of T4 isolates in keratitis cases may well be due to their greater virulence. This is the first report presenting environmental distribution of Acanthamoeba in Ankara, Turkey

A national register for surveillance of inherited disorders: beta thalassaemia in the United Kingdom

OBJECTIVE: To demonstrate the value of a national register for surveillance of services for an inherited disorder. METHODS: Data from the United Kingdom Thalassaemia Register and the United Kingdom Register of Prenatal Diagnosis for Haemoglobin Disorders were combined in a database; these registers include all fetuses known to have been diagnosed with beta thalassaemia major, beta thalassaemia intermedia, or haemoglobin E/beta thalassaemia in the United Kingdom. Data were extracted to show outcomes (selective abortion or live birth) of all fetuses and the status of those born with a disorder (alive, dead, successful bone marrow transplant, or lost to follow-up) by parents' region of residence and ethnicity. FINDINGS: At the end of 1999 the register included 1074 patients, 807 of whom were alive and residing in the United Kingdom. A successful bone marrow transplant has been performed for 117 out of 581 (20%) patients born since 1975. Residents of Pakistani origin are now the main group at risk in the United Kingdom, replacing residents of Cypriot origin. This has led to a marked shift in the need for services from the south-east of England to the Midlands and the north of England. Despite the acceptability of prenatal diagnosis, the proportion of affected births remains 50% higher than would be expected, reflecting a widespread failure to deliver timely screening and counselling to carriers. Even though effective treatment is available the annual number of deaths is rising, indicating that better tolerated treatments are needed. CONCLUSION: A national diagnosis register is a powerful instrument for monitoring the treatment and prevention of inherited disorders and for highlighting correctable shortcomings. In view of the increasing possibilities for genetic screening there is a strong case for central funding for such databases within modern health services

Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma

Asthma is a common medical problem in Pakistan. Allergic Bronchopulmonary Aspergillosis (ABPA), an immune mediated disease, is an unusual complication of bronchial asthma which can result in bronchiectasis, pulmonary fibrosis, respiratory failure and death. Early diagnosis is important so that with proper therapy permanent lung damage can be prevented. First described in 19521 , ABPA was thought to be a rare disorder, but with increased awareness amongst the physicians and better diagnostic techniques, äases are being recognized more frequently. The clinical features of ABPA (cough, fever, hemoptysis and lung infiltrates) are usually mistaken for pulmonary tuberculosis (TB). We present three cases in which failure to consider the diagnosis of ABPA resulted in repeated courses of anti-TB therapy and/or progressive lung damage and continued morbidit