GI2T/REGAIN spectro-interferometry with a new infrared beam combiner

We have built an infrared beam combiner for the GI2T/REGAIN interferometer of the Observatoire de la Cote d'Azur. The beam combiner allows us to record spectrally dispersed Michelson interference fringes in the near-infrared J-, H- or K-bands. The beam combiner has the advantage that Michelson interferograms can simultaneously be recorded in about 128 different spectral channels. The tilt of the spectrally dispersed fringes is a measure of the instantaneous optical path difference. We present the optical design of the beam combiner and GI2T/REGAIN observations of the Mira star R Cas with this beam combiner in the spectral range of 2.00 micron - 2.18 micron (observations on 22 and 25 August 1999; variability phase 0.08; V-magnitude approx. 6; seven baselines between 12m and 24m; reference stars Vega and Beta Peg). The spectrograph of the beam combiner consists of an anamorphotic cylindrical lens system, an image plane slit, and a grism. A system of digital signal processors calculates the ensemble average power spectrum of the spectrally dispersed Michelson interferograms and the instantaneous optical path difference error in real time. From the observed R Cas visibilities at baselines 12.0m, 13.8m and 13.9m, a 2.1 micron uniform-disk diameter of 25.3mas +/-3.3mas was derived. The unusually high visibility values at baselines >16m show that the stellar surface of R Cas is more complex than previously assumed. The visibility values at baselines >16m can be explained by high-contrast surface structure on the stellar surface of R Cas or other types of unexpected center-to-limb variations. The R Cas observations were compared with theoretical Mira star models yielding a linear Rosseland radius of 276Rsun +/-66Rsun and an effective temperature of 2685K+/-238K for R Cas at phase 0.08.Comment: 10 pages, 6 figures, see also http://www.mpifr-bonn.mpg.de/div/speckle, SPIE conf 4006 "Interferometry in Optical Astronomy", in pres

A Comprehensive & Systematic Study of Coincidence Time Resolution and Light Yield Using Scintillators of Different Size and Wrapping

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Economic burden of vulvar and vaginal intraepithelial neoplasia: retrospective cost study at a German dysplasia centre

<p>Abstract</p> <p>Background</p> <p>Human papillomavirus is responsible for a variety of diseases including grade 2 and 3 vulvar and vaginal intraepithelial neoplasia. The aim of this study was to assess parts of the burden of the last diseases including treatment costs. The direct medical resource use and cost of surgery associated with neoplasia and related diagnostic procedures (statutory health insurance perspective) were estimated, as were the indirect costs (productivity losses) associated with surgical treatment and related gynaecology visits for diagnostic purposes.</p> <p>Methods</p> <p>Data from 1991-2008 were retrospectively collected from patient records of the outpatient unit of the Gynaecological Dysplasia Clinic, Heinrich Heine University, Dusseldorf, Germany. Two subgroups of patients were analysed descriptively: women undergoing one surgical procedure related to a diagnosis of vulvar and/or vaginal intraepithelial neoplasia, and women undergoing two or more surgical procedures. Target measures were per-capita medical resource consumption, direct medical cost and indirect cost.</p> <p>Results</p> <p>Of the 94 women analysed, 52 underwent one surgical intervention and 42 two or more interventions (mean of 3.0 interventions during the total period of analysis). Patients undergoing one surgical intervention accrued €881 in direct costs and €682 in indirect costs; patients undergoing more than one intervention accrued €2,605 in direct costs and €2,432 in indirect costs.</p> <p>Conclusions</p> <p>The economic burden on German statutory health insurance funds and society induced by surgical interventions and related diagnostic procedures for grade 2/3 vulvar and vaginal neoplasia should not be underrated. The cost burden is one part of the overall burden attributable to human papillomavirus infections.</p

Use of Surrogate end points in HTA

The different actors involved in health system decision-making and regulation have to deal with the question which are valid parameters to assess the health value of health technologies

Charge collection properties of TowerJazz 180 nm CMOS Pixel Sensors in dependence of pixel geometries and bias parameters, studied using a dedicated test-vehicle: the Investigator chip

This paper contains a compilation of parameters influencing the charge collection process extracted from a comprehensive study of partially depleted Monolithic Active Pixel Sensors with small (<25 um$^2$) collection electrodes fabricated in the TowerJazz 180 nm CMOS process. These results gave guidance for the optimisation of the diode implemented in ALPIDE, the chip used in the second generation Inner Tracking System of ALICE, and serve as reference for future simulation studies of similar devices. The studied parameters include: reverse substrate bias, epitaxial layer thickness, charge collection electrode size and the spacing of the electrode to surrounding in-pixel electronics. The results from pixels of 28 um pitch confirm that even in partially depleted circuits, charge collection can be fast (<10 ns), and quantify the influence of the parameters onto the signal sharing and amplitudes, highlighting the importance of a correct spacing between wells and of the impact of the reverse substrate bias

Incidence of anogenital warts in Germany: a population-based cohort study

<p>Abstract</p> <p>Background</p> <p>Human papilloma virus (HPV) types 6 and 11 account for 90 percent of anogenital warts (AGW). Assessment of a potential reduction of the incidence of AGW following introduction of HPV vaccines requires population-based incidence rates. The aim of this study was to estimate incidence rates of AGW in Germany, stratified by age, sex, and region. Additionally, the medical practitioner (gynaecologist, dermatologist, urologist etc.) who made the initial diagnosis of AGW was assessed.</p> <p>Methods</p> <p>Retrospective cohort study in a population aged 10 to 79 years in a population-based healthcare insurance database. The database included more than 14 million insurance members from all over Germany during the years 2004-2006. A case of AGW was considered incident if a disease-free period of twelve months preceded the diagnosis. To assess regional variation, analyses were performed by federal state.</p> <p>Results</p> <p>The estimated incidence rate was 169.5/100,000 person-years for the German population aged 10 to 79 years. Most cases occurred in the 15 to 40 years age group. The incidence rate was higher and showed a peak at younger ages in females than in males. The highest incidence rates for both sexes were observed in the city-states Berlin, Hamburg and Bremen. In females, initial diagnosis of AGW was most frequently made by a gynaecologist (71.7%), whereas in males, AGW were most frequently diagnosed by a dermatologist (44.8%) or urologist (25.1%).</p> <p>Conclusions</p> <p>Incidence of AGW in Germany is comparable with findings for other countries. As expected, most cases occurred in the younger age groups. The frequency of diagnoses of AGW differs between sexes and women and men receive treatment by doctors of different specialties.</p