Conceptual design of elliptical cavities for intensity and position sensitive beam measurements in storage rings

Position sensitive beam monitors are indispensable for the beam diagnostics in storage rings. Apart from their applications in the measurements of beam parameters, they can be used in non-destructive in-ring decay studies of radioactive ion beams as well as enhancing precision in the isochronous mass measurement technique. In this work, we introduce a novel approach based on cavities with elliptical cross-section, in order to compensate for existing limitations in ion storage rings. The design is aimed primarily for future heavy ion storage rings of the FAIR project. The conceptual design is discussed together with simulation results.Comment: Added definition of Uv and Pdiss in the introduction section. Added Mode numbering in table 1 and figure 1 for more clarity. Corrected one wrong figure reference. Other minor typo correction

Nonreciprocity induces resonances in two-field Cahn-Hilliard model

We consider a non-reciprocically coupled two-field Cahn-Hilliard system that has been shown to allow for oscillatory behaviour, a suppression of coarsening as well as the existence of localised states. Here, after introducing the model we first briefly review the linear stability of homogeneous states and show that all instability thresholds are identical to the ones for a corresponding Turing system (i.e., a two-species reaction-diffusion system). Next, we discuss possible interactions of linear modes and analyse the specific case of a ``Hopf-Turing'' resonance by discussing corresponding amplitude equations in a weakly nonlinear approach. The thereby obtained states are finally compared with fully nonlinear simulations for a specific conserved amended FitzHugh-Nagumo system. We conclude by a discussion of the limitations of the weakly nonlinear approach

Analysis of the serotonergic system in a mouse model of Rett syndrome reveals unusual upregulation of serotonin receptor 5b

Mutations in the transcription factor methyl-CpG-binding-protein 2 (MeCP2) cause a delayed-onset neurodevelopmental disorder known as Rett syndrome (RTT). Although alteration in serotonin levels have been reported in RTT patients, the molecular mechanisms underlying these defects are not well understood. Therefore, we chose to investigate the serotonergic system in hippocampus and brainstem of male Mecp2(-/y) knock-out mice in the B6.129P2(C)-Mecp2(tm1.1Bird) mouse model of RTT. The serotonergic system in mouse is comprised of 16 genes, whose mRNA expression profile was analyzed by quantitative RT-PCR. Mecp2(-/y) mice are an established animal model for RTT displaying most of the cognitive and physical impairments of human patients and the selected areas receive significant modulation through serotonin. Using anatomically and functional characterized areas, we found region-specific differential expression between wild type and Mecp2(-/y) mice at post-natal day 40. In brainstem, we found five genes to be dysregulated, while in hippocampus, two genes were dysregulated. The one gene dysregulated in both brain regions was dopamine decarboxylase, but of special interest is the serotonin receptor 5b (5-ht(5b)), which showed 75-fold dysregulation in brainstem of Mecp2(-/y) mice. This dysregulation was not due to upregulation, but due to failure of down-regulation in Mecp2(-/y) mice during development. Detailed analysis of 5-ht(5b) revealed a receptor that localizes to endosomes and interacts with G(αi) proteins

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes

Sulforhodamine 101 (SR101) is widely used for astrocyte identification, though the labeling mechanism remains unknown and the efficacy of labeling in different brain regions is heterogeneous. By combining region-specific isolation of astrocytes followed by transcriptome analysis, two-photon excitation microscopy, and mouse genetics, we identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-013-0645-0) contains supplementary material, which is available to authorized users

Q-band EPR cryoprobe

Following the success of cryogenic EPR signal preamplification at X-band, we present a Q-band EPR cryoprobe compatible with a standard EPR resonator. The probehead is equipped with a cryogenic ultra low-noise microwave amplifier and its protection circuit that are placed close to the sample in the same cryostat. Our cryoprobe maintains the same sample access and tuning which is typical in Q-band EPR, as well as supports high-power pulsed experiments on typical samples. The performance of our setup is benchmarked against that of existing commercial and home-built Q-band spectrometers, using CW EPR and pulsed EPR/ENDOR experiments to reveal a significant sensitivity improvement which reduces the measurement time by a factor of about 40× at 6 K temperature at reduced power levels