139 research outputs found

    Efficacy and safety of Black cohosh (Actaea/Cimicifuga racemosa) in the treatment of vasomotor symptoms – review of clinical trials

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    Abstract The occurrence of vasomotor symptoms in women is directly related to deficiency of estrogen, which occurs as a result of natural or surgical menopause. Hot flushes may also be a major problem for patients with a history of breast cancer, as they may result directly from cancer treatment (oophorectomy, chemotherapy-induced ovarian failure or adjuvant tamoxifen citrate therapy). Despite the lack of reliable data regarding their efficacy and safety, in recent years the usage of herbs among menopausal women has increased dynamically all over the world. The following paper reviews professional literature about Black Cohosh (Actaea/Cimicifuga racemosa), either used alone or in combination with other medicinal herbs administered in management of vasomotor symptoms. Extracts of the rootstock of Black cohosh contain such potentially biologically active constituents as triterpene glycosides (actein, cimicifugoside, deoxyacetein), isoferulic acid and alkaloids (n-methylcytisine). The mechanism of its action remains unclear. Some authors suggest that Black Cohosh contains substances with selective estrogen receptor modulator (SERM) activity. Recent data has demonstrated that Black Cohosh may have an effect on dopaminergic and serotoninergic systems. Thirty-two papers formed the basis for this review. Openlabel, noncomparative studies, as well as treatment-controlled, randomized, open trials, have proven that Black Cohosh significantly reduced frequency or severity of hot flashes. The results of randomized, placebo-controlled, double-blind clinical trials were contradictory. Adverse symptoms have been rare (5,4%), mild and reversible. Most of them included gastrointestinal upsets, rashes, headaches, dizziness and mastalgia. Nevertheless, single cases of serious adverse events, including acute hepatocellular damage, have been reported, but without a clear causality relationship

    The expression of B7-H1 and B7-H4 molecules on immature myeloid and lymphoid dendritic cells in cord blood of healthy neonates.

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    The aim of our study was to estimate both B7-H1 and B7-H4 molecules on immature myeloid and lymphoid dendritic cells in umbilical cord blood of healthy neonates in comparison with peripheral blood of healthy adults. Thirty nine healthy full-term neonates from physiological single pregnancies and 27 healthy adults were included in the study. The expression of B7-H1 and B7-H4 was revealed using the immunofluorescence method. Statistical analysis was performed using a non-parametric test (Mann-Whitney U-Test). The percentages of BDCA-1+ dendritic cells with B7-H1 and B7-H4 expressions were significantly higher in peripheral blood of healthy adults (

    Transhumant pastoralism in Poland: Contemporary challenges

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    Since the mid-2000s, transhumant pastoralism and the production of artisanal sheep’s cheeses have experienced a revival in the Polish Carpathians. This revival has largely coincided with Poland’s accession to the European Union in 2004, leading to a re-valuation of extensive livestock production from an economic and environmental liability to a form of ‘High Nature Value’ farming. Supported by Common Agricultural Policy CAP European Union subsidies, Polish pastoralists have been re-classified from being producers of livestock and agricultural products to suppliers of environmental and ecosystem services. Despite these changes, however, they continue to face significant systemic challenges which are rooted in the marked decline of the communist-era pastoral economy in the late 1980s and a subsequent increasing competition for land and labour under market conditions. Based on anthropological fieldwork conducted in Poland’s Carpathian Highland region during the 2015, 2016, and 2017 pastoral seasons, this article provides insight into four sets of challenges deemed most important by working shepherds today: recruiting qualified labour, gaining access to pasture, gaining access to markets, and working within a Polish policy environment which fails to recognise the particular conditions and requirements of pastoral agriculture

    Reducing the development gaps between regions in Poland with the use of European Union funds

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    The paper evaluates the processes of regional income convergence in Poland. This new research approach involves an attempt to assess the process of convergence from the point of view of development gaps. Six key development gaps were considered in the region of Eastern Poland, which is a singular case, significantly different from other regions. A dynamic panel data model was applied to investigate the impact of EU funds on the progress made towards closing these development gaps. Among the analysed development gaps, only the structural gap was not reduced in the period 2004–2015. Studies have also revealed the different impact of structural funds on each category of development gaps (a positive impact on reducing the regional transport accessibility gap and the investment gap, but negative – on reducing the innovation gap). Research has suggested the need for a change in the structure of using EU funds in the period 2014–2020 to favour stronger support for entrepreneurship and the creation of new jobs. Greater stimulation of the economic structure of peripheral regions has been proposed as the prerequisite for the future reduction in the discrepancies between regions and for the intensification of convergence. First published online 2 April 201

    Governance capacity and regionalist dynamics

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    The debate on the effects of regionalism and European integration on European nation states has been prominent for more than a decade. Regionalization of EU states has not brought with it genuine regional autonomy and regionalism has not emerged as a bottom-up public demand in European regions. It is contended here that to determine the future of regional devolution, whether as a result of bottom-up or top-down processes, the factors at play must be contextualized. This paper examines some determinants of regional political capacity, as identified in the policy literature, in tandem with a number of determinants of economic prospects and the existence of an economic milieu. This is done in a comparative context across 12 regions of the EU. It is suggested that the potential for regionalist pressures to emerge is dependent on regional governance capacity and the relative economic weight of a region. © Taylor & Francis
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