3-[(1-Hy­droxy-1-phenyl­propan-2-yl)amino]-5,5-dimethyl­cyclo­hex-2-enone

The asymmetric unit of the title compound, C17H23NO2, consists of two crystallographically independent mol­ecules (A and B). The cyclo­hexene rings in both mol­ecules adopt an envelope conformation. In the crystal, independent mol­ecules, A and B, are each linked by inter­molecular bifurcated (N,O)—H⋯O hydrogen bonds, generating R 2 1(7) ring motifs and forming infinite chains along the b axis

Identifying common user behaviour in multilingual search logs

The LADS (Log Analysis for Digital Societies) task at CLEF aims at investigating user actions in a multilingual setting. We carried out an analysis of search logs with the objectives of investigating how users from different linguistic or cultural backgrounds behave in search, and how the discovery of patterns in user actions could be used for community identification. The findings confirm that users from a different background behave differently, and that there are identifiable patterns in the user actions. The findings suggest that there is scope for further investigation of how search logs can be exploited to personalise and improve cross-language search as well as improve the TEL search system

DCU-TCD@LogCLEF 2010: re-ranking document collections and query performance estimation

This paper describes the collaborative participation of Dublin City University and Trinity College Dublin in LogCLEF 2010. Two sets of experiments were conducted. First, different aspects of the TEL query logs were analysed after extracting user sessions of consecutive queries on a topic. The relation between the queries and their length (number of terms) and position (first query or further reformulations) was examined in a session with respect to query performance estimators such as query scope, IDF-based measures, simplified query clarity score, and average inverse document collection frequency. Results of this analysis suggest that only some estimator values show a correlation with query length or position in the TEL logs (e.g. similarity score between collection and query). Second, the relation between three attributes was investigated: the user's country (detected from IP address), the query language, and the interface language. The investigation aimed to explore the influence of the three attributes on the user's collection selection. Moreover, the investigation involved assigning different weights to the three attributes in a scoring function that was used to re-rank the collections displayed to the user according to the language and country. The results of the collection re-ranking show a significant improvement in Mean Average Precision (MAP) over the original collection ranking of TEL. The results also indicate that the query language and interface language have more in uence than the user's country on the collections selected by the users

INDUSTRIALIZATION OF MEDROXY PROGESTERONE ACETATE IN PROLONGED PARENTAL SUSPENSION (PART I)

Objective: Medroxy progesterone acetate (MPA) is structurally related to progesterone it is given by mouth or by intramuscular (IM) as a contraceptive in an aqueous suspension injection. It was reported that the MPA suspension was chemically and physically unstable due to a reaction between the different excipients. Evaluate the effect of different antioxidants as L-cysteine, ascorbic acid, sodium metabisulfate and D-L methionine (DLM) on the stability of MPA in suspension formula, as well as comparative studies was conducted to evaluate the most promising formula with the marketed product. On the other hand, the thermal and photo-stability study for the selected formula was done to determine the conditions of storage on the product formula.Methods: Four preparations were prepared by adding either DLM (0.15 gm %), ascorbic acid (0.03 gm %), sodium metabisulfate (SMBS) (0.25 gm) or combination of SMBS with ascorbic acid as an antioxidant, all ingredients we mixed together using (Heidolph) homogenizeResults: Indicate that, the formula contains 0.3 gm of polysorbate 80, PVP, paraben ester and 0.13 gm % phosphate buffer with DLM or ascorbic acid as an antioxidant revealed acceptable pH stability which was studied by FT-IR, X-ray diffraction and particle size analysis.Conclusion: Formula with DLM (F-DLM) showed good rheological behavior. Thermal degradation of the suspension formula with ascorbic acid (F-ascorbic acid) or DLM revealed acceptable shelf life for more than 4 years for F-DLM and about 2 years for the F-ascorbic acid while the two formulae exhibited dramatic photo degradation under UV lamp of the 3 month studyÂ

Sinteza, in vitro antitumorsko ispitivanje i radiosenzitirajuće vrednovanje novih derivata 4-[3-(supstituiranih)tioureido]-N-(kinoksalin-2-il)benzensulfonamida

Sulfonamides and quinoxaline derivatives possess many types of biological activities and have been recently reported to show substantial antitumor activity. This paper reports the synthesis of novel thioureidosulfaquinoxaline derivatives. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against a human liver cell line (HEPG2) and showed higher activity than the reference drug doxorubicin. 4-(3-(4-Ethylbenzoate)thioureido)-N-(quinoxalin-2-yl)benzenesulfonamide (9) (IC50 = 15.6 µmol L1), N-(pyridin-2-yl)-4-(3-(4-(N-quinoxalin-2-yl-sulfamoyl)phenyl)thioureido)benzene-sulfonamide (10) (IC50 = 26.8 µmol L1) and N-(quinoxalin-2-yl)-4-(3-(4-(N-thiazol-2-ylsulfamoyl)phenyl)thioureido)benzenesulfonamide (11) (IC50 = 24.4 µmol L1) were the most potent compared to doxorubicin (IC50 = 71.8 µmol L1). The most potent compounds 9, 10 and 11 were evaluated as radiosensitizing agents by subjecting the compounds to γ-irradiation (8 kGy).Derivati sulfonamida i kinoksalina imaju raznoliko biološko djelovanje, između ostalog i antitumorsko djelovanje. U radu je opisana sinteza novih derivata tioureido sulfakinoksalina. Svim novim spojevima ispitano je antitumorsko djelovanje in vitro na humanoj staničnoj liniji jetre (HEPG 2). Svi ispitani spojevi pokazuju jači učinak nego referentni lijek doksorubicin. Najjači učinak imali su 4-(3-(4-etilbenzoat)tioureido)-N-(kinoksalin-2-il)benzen-sulfonamid (9) (IC50 = 15,6 µmol L1), N-(piridin-2-il)-4-(3-(4-(N-kinoksalin-2-il-sulfamoil)fenil)tioureido)-benzen-sulfonamid (10) (IC50 = 26,8 µmol L1) i N-(kinoksalin-2-il)-4-(3-(4-(N-tiazol-2-ilsulfamoil)fenil)tioureido)benzen-sulfonamid (11) (IC50 = 24,4 µmol L1), dok je IC50 vrijednost bila 71,8 µmol L1. Najaktivniji spojevi 9, 10 i 11 evaluirani su kao radziosenzitirajuća sredstva nakon izlaganja spojeva γ-zračenju (8 kGy)

Absolute configuration of (1S,2S)-3-methyl-2-phenyl-2,3-dihydro­thia­zolo[2,3-b]quinazolin-5-one

The absolute structure of the molecule in the crystal of the title compound, C17H14N2OS, was determined by the refinement of the Flack parameter to 0.0 (2) based on 1011 Friedel pairs. The quinazoline ring is essentially planar, with a maximum deviation of 0.037 (2) Å. The thia­zole ring is distorted from planarity [maximum deviation = 0.168 (2) Å] and adopts a slightly twisted envelope conformation, with the C atom as the flap atom. The central thia­zole ring makes dihedral angles of 7.01 (8) and 76.80 (10)° with the quinazoline and phenyl rings, respectively. The corresponding angle between the quinazoline and phenyl rings is 3.74 (9)°. In the crystal, there are no classical hydrogen bonds but stabilization is provided by weak C—H⋯π inter­actions, involving the centroids of the phenyl rings

Multilingual adaptive search for digital libraries

This paper describes a framework for Adaptive Multilingual Information Retrieval (AMIR) which allows multilingual resource discovery and delivery using on-the-fly machine translation of documents and queries. Result documents are presented to the user in a contextualised manner. Challenges and affordances of both Adaptive and Multilingual IR, with a particular focus on Digital Libraries, are detailed. The framework components are motivated by a series of results from experiments on query logs and documents from The European Library. We conclude that factoring adaptivity and multilinguality aspects into the search process can enhance the user’s experience with online Digital Libraries

(E)-4-Amino-N-(1,2-dihydro­pyridin-2-yl­idene)benzene­sulfonamide nitro­methane monosolvate

In the title solvate, C11H11N3O2S·CH3NO2, the dihedral angle between the benzene ring and the N-containing ring is 85.94 (11)°, and an approximate V shape arises for the sulfonamide mol­ecule. In the crystal, N—H⋯O and N—H⋯N hydrogen bonds and weak C—H⋯O inter­actions link the sulfonamide mol­ecules into a three-dimensional network. The nitro­methane solvent mol­ecules are located in the inter­stitial sites in the sulfonamide network

The Effect of Corporate Cultural Factors on the Data Warehousing Success: An Empirical Investigation

This study is aimed at identifying the impact of corporate cultural factors on successful development of data warehousing in the United Arab Emirates. The theoretical framework of the study is formulated based on analysis of related literature coupled with the information gained from interviewing data warehousing experts. Five hundred and eighty data warehouse users in 34 companies were surveyed to obtain their perceptions of the extent that each of 132 items had actually contributed to their firms’ DW success at different phases of development. Rigorous multivariate statistical analysis procedure has been followed to design and construct an overall model of DW success. The model has proven that all its independent variables have significant influence on the DW overall success and that corporate cultural factors have dominant impact on this success throughout the different phases of DW development

EFFECT OF ADDITIVES ON IN-VITRO RELEASE OF ORODISPERSIBLE DOSAGE FORM

Objective: The aim of this investigation was to prepare orodispersible tablets of meloxicam using various concentrations of superdisintegrants like Ac-DI-Sol, crospovidone, sodium starch glycolate by the direct compression method. Methods: Nine formulae of Meloxicam orodispersible tablets were prepared. These tablets were evaluated for their drug content, weight variation, friability, hardness, wetting time, In-vitro disintegration time and drug release.Results: All the formulation exhibited hardness between 4.21–4.55 kg/cm2. The tablets were disintegrating within 8.3 to 21.9 sec. Dissolution studies revealed that formula containing 7.5 % sodium starch glycolate showed 100% of drug release, at the end of six minutes. Among the formulated tablets, formula F9 containing 7.5 % sodium starch glycolate showed superior organoleptic properties along with excellent In-vitro disintegration time and drug release as compared to other formulae. The concentration of superdisintegrants had an effect on disintegration time and In-vitro drug dissolution whereas hardness and friability of resulting tablets were found to be independent of disintegrant concentration. It was concluded that the superdisintegrants addition technique is a useful method for preparing orodispersible tablets by the direct compression method.Â