226 research outputs found
Enteroviral Infections in the First Three Months of Life
Enteroviruses (EVs) are an important source of infection in the paediatric age, with most cases concerning the neonatal age and early infancy. Molecular epidemiology is crucial to understand the circulation of main serotypes in a specific area and period due to their extreme epidemiological variability. The diagnosis of EVs infection currently relies on the detection of EVs RNA in biological samples (usually cerebrospinal fluid and plasma, but also throat swabs and feces) through a poly-merase chain reaction assay. Although EVs infections usually have a benign course, they sometimes become life threatening, especially when symptoms develop in the first few days of life. Mortality is primarily associated with myocarditis, acute hepatitis, and multi-organ failure. Neurodevelopmental sequelae have been reported following severe infections with central nervous system involvement. Unfortunately, at present, the treatment of EVs infections is mainly supportive. The use of specific antiviral agents in severe neonatal infections has been reported in single cases or studies includ-ing few neonates. Therefore, further studies are needed to confirm the efficacy of these drugs in clinical practice
Sudden Unexpected Postnatal Collapse and Therapeutic Hypothermia: Whatâs Going On?
Sudden unexpected postnatal collapse (SUPC) is a rare event, potentially associated with catastrophic consequences. Since the beginning of the 2000s, therapeutic hypothermia (TH) has been proposed as a treatment for asphyxiated neonates after SUPC. However, only a few studies have reported the outcome of SUPC after TH. The current study presents the long-term neurodevelopmental outcome of four cases of SUPC treated with TH in a single Italian center. Furthermore, we reviewed the previous literature concerning 49 cases of SUPC treated with TH. Among 53 total cases (of whom four occurred in our center), 15 (28.3%) died before discharge from the NICU. A neurodevelopmental follow-up was available only for 21 (55.3%) out of the 38 surviving cases, and seven infants developed neurodevelopmental sequelae. TH should be considered in neonates with asphyxia after SUPC. However, SUPC is a rare event, and there is a lack of comparative clinical data to establish the risk/benefit of TH after SUPC with different degrees of asphyxia. Analysis of large cohorts of newborns with SUPC, whether treated with TH or untreated, are needed in order to better identify infants who should undergo TH
Lifecycle Management in the Smart City Context: Smart Parking Use-Case
Lifecycle management enables enterprises to manage their products, services and product-service bundles. IoT and CPS have made products and services smarter by closing the loop of data across different phases of lifecycle. Similarly, CPS and IoT empower cities with real-time data streams from heterogeneous objects. Yet, cities are smarter and more powerful when relevant data can be exchanged between different systems across different domains. From engineering perspective, smart city can be seen as a System of Systems composed of interrelated/ interdependent smart systems and objects. To better integrate people, processes, and systems in the smart city ecosystem, this paper discusses the use of Lifecycle Management in the smart city context. Considering the differences between ordinary and smart service systems, this paper seeks better understanding of lifecycle aspects in the smart city context. For better understanding, some of the discussed lifecycle aspects are demonstrated in a smart parking use-case
Preliminary results on the long term operation of RPCs with eco-friendly gas mixtures under irradiation at the CERN Gamma Irradiation Facility
Since 2019 a collaboration between researchers from various institutes and
experiments (i.e. ATLAS, CMS, ALICE, LHCb/SHiP and the CERN EP-DT group), has
been operating several RPCs with diverse electronics, gas gap thicknesses and
detector layouts at the CERN Gamma Irradiation Facility (GIF++). The studies
aim at assessing the performance of RPCs when filled with new eco-friendly gas
mixtures in avalanche mode and in view of evaluating possible ageing effects
after long high background irradiation periods, e.g. High-Luminosity LHC phase.
This challenging research is also part of a task of the European AidaInnova
project.
A promising eco-friendly gas identified for RPC operation is the
tetrafluoruropropene (CHF, commercially known as HFO-1234ze)
that has been studied at the CERN GIF++ in combination with different
percentages of CO. Between the end of 2021 and 2022 several beam tests have
been carried out to establish the performance of RPCs operated with such
mixtures before starting the irradiation campaign for the ageing study.
Results of these tests for different RPCs layouts and different gas mixtures,
under increasing background rates are presented here, together with the
preliminary outcome of the detector ageing tests
Social Media, Gender and the Mediatisation of War: Exploring the German Armed Forcesâ Visual Representation of the Afghanistan Operation on Facebook
Studies on the mediatisation of war point to attempts of governments to regulate the visual perspective of their involvements in armed conflict â the most notable example being the practice of âembedded reportingâ in Iraq and Afghanistan. This paper focuses on a different strategy of visual meaning-making, namely, the publication of images on social media by armed forces themselves. Specifically, we argue that the mediatisation of war literature could profit from an increased engagement with feminist research, both within Critical Security/Critical Military Studies and within Science and Technology Studies that highlight the close connection between masculinity, technology and control. The article examines the German military mission in Afghanistan as represented on the German armed forcesâ official Facebook page. Germany constitutes an interesting, and largely neglected, case for the growing literature on the mediatisation of war: its strong antimilitarist political culture makes the representation of war particularly delicate. The paper examines specific representational patterns of Germanyâs involvement in Afghanistan and discusses the implications which arise from what is placed inside the frame of visibility and what remains out of its view
Product Lifecycle Management Approach for Sustainability
Organised by: Cranfield UniversityStarting from the framework of Product Lifecycle Management (PLM), sustainability should be provided by
continuous sharing of information among the different product lifecycle phases. A PLM system provides
lifecycle knowledge generated by PLM systems through product lifecycle activities. The paper aims at
presenting how PLM systems represent a very important foundation for achieving a more sustainable
paradigm for life, a more sustainable development, engineering, manufacturing, use and disposal of
products.Mori Seiki â The Machine Tool Compan
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