Real-Time Expert System for Control of Electrophysical Complex

This work is the continuation of research in the field of a real-time expert system (RTES) prototype for control electrophysical complex (EC) [1,2]. The work was realized with the Gensym’s G2 (USA), development environment for creating and deploying intelligent realtime application. The main goal was the modernization of the previous RTES version by adding new subsystems in the scope of the existing features. This became possible thanks to the new technologies of dynamic expert system. In particular the problem-oriented G2-based product such as G2 Diagnostic Assistant (GDA) was used. It must be noticed that RTES is oriented to wide range of specialists in the EC’s area. All of them have different experience not onl

Evaluation of a web-based asthma self-management system: a randomised controlled pilot trial

Background Asthma is the most common chronic condition of childhood and disproportionately affects inner-city minority children. Low rates of asthma preventer medication adherence is a major contributor to poor asthma control in these patients. Web-based methods have potential to improve patient knowledge and medication adherence by providing interactive patient education, monitoring of symptoms and medication use, and by facilitation of communication and teamwork among patients and health care providers. Few studies have evaluated web-based asthma support environments using all of these potentially beneficial interventions. The multidimensional website created for this study, BostonBreathes, was designed to intervene on multiple levels, and was evaluated in a pilot trial. Methods An interactive, engaging website for children with asthma was developed to promote adherence to asthma medications, provide a platform for teamwork between caregivers and patients, and to provide primary care providers with up-to-date symptom information and data on medication use. Fifty-eight (58) children primarily from inner city Boston with persistent-level asthma were randomised to either usual care or use of BostonBreathes. Subjects completed asthma education activities, and reported their symptoms and medication use. Primary care providers used a separate interface to monitor their patients’ website use, their reported symptoms and medication use, and were able to communicate online via a discussion board with their patients and with an asthma specialist. Results After 6-months, reported wheezing improved significantly in both intervention and control groups, and there were significant improvements in the intervention group only in night-time awakening and parental loss of sleep, but there were no significant differences between intervention and control groups in these measures. Emergency room or acute visits to a physician for asthma did not significantly change in either group. Among the subgroup of subjects with low controller medication adherence at baseline, adherence improved significantly only in the intervention group. Knowledge of the purpose of controller medicine increased significantly in the intervention group, a statistically significant improvement over the control group. Conclusions This pilot study suggests that a multidimensional web-based educational, monitoring, and communication platform may have positive influences on pediatric patients’ asthma-related knowledge and use of asthma preventer medications

Fano Resonance Between Mie and Bragg Scattering in Photonic Crystals

We report the observation of a Fano resonance between continuum Mie scattering and a narrow Bragg band in synthetic opal photonic crystals. The resonance leads to a transmission spectrum exhibiting a Bragg dip with an asymmetric profile, which can be tunably reversed to a Bragg rise. The Fano asymmetry parameter is linked with the dielectric contrast between the permittivity of the filler and the specific value determined by the opal matrix. The existence of the Fano resonance is directly related to disorder due to non-uniformity of a-SiO2 opal spheres. Proposed theoretical "quasi-3D" model produces results in excellent agreement with the experimental data

Nonlinear interaction of light with Bose-Einstein condensate: new methods to generate subpoissonian light

We consider $\Lambda$-type model of the Bose-Einstein condensate of sodium atoms interacting with the light. Coefficients of the Kerr-nonlinearity in the condensate can achieve large and negative values providing the possibility for effective control of group velocity and dispersion of the probe pulse. We find a regime when the observation of the "slow" and "fast" light propagating without absorption becomes achievable due to strong nonlinearity. An effective two-level quantum model of the system is derived and studied based on the su(2) polynomial deformation approach. We propose an efficient way for generation of subpoissonian fields in the Bose-Einstein condensate at time-scales much shorter than the characteristic decay time in the system. We show that the quantum properties of the probe pulse can be controlled in BEC by the classical coupling field.Comment: 13 pages, 6 figures, 1 tabl

Geant4 simulation of production and interaction of muons

A set of models for Monte Carlo simulation of production and interaction of high energy muons is developed in the framework of the Geant4 toolkit. It describes the following physics processes: ionization of high energy muons with radiative corrections, bremsstrahlung, electron-positron pair production, muon induced nuclear reactions, gamma annihilation into muon pair, positron annihilation into muon pair, and into pion pair. These processes are essential for the LHC experiments, for the understanding of the background in underground detectors, for the simulation of effects related with high-energy muons in cosmic ray experiments and for the estimation of backgrounds in future colliders. The applicability area of the models extends to 1 PeV. The major use-cases are discussed

Quantum integrable multi atom matter-radiation models with and without rotating wave approximation

New integrable multi-atom matter-radiation models with and without rotating wave approximation (RWA) are constructed and exactly solved through algebraic Bethe ansatz. The models with RWA are generated through ancestor model approach in an unified way. The rational case yields the standard type of matter-radiaton models, while the trigonometric case corresponds to their q-deformations. The models without RWA are obtained from the elliptic case at the Gaudin and high spin limit.Comment: 9 pages, no figure, talk presented in int. conf. NEEDS04 (Gallipoli, Italy, July 2004

The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion

Bromodomain and extraterminal domain (BET) proteins have emerged as therapeutic targets in multiple cancers, including the most common primary adult brain tumor glioblastoma (GBM). Although several BET inhibitors have entered clinical trials, few are brain penetrant. We have generated UM-002, a novel brain penetrant BET inhibitor that reduces GBM cell proliferation in vitro and in a human cerebral brain organoid model. Since UM-002 is more potent than other BET inhibitors, it could potentially be developed for GBM treatment. Furthermore, UM-002 treatment reduces the expression of cell-cycle related genes in vivo and reduces the expression of invasion related genes within the non-proliferative cells present in tumors as measured by single cell RNA-sequencing. These studies suggest that BET inhibition alters the transcriptional landscape of GBM tumors, which has implications for designing combination therapies. Importantly, they also provide an integrated dataset that combines in vitro and ex vivo studies with in vivo single-cell RNA-sequencing to characterize a novel BET inhibitor in GBM

Exact solutions for a family of spin-boson systems

We obtain the exact solutions for a family of spin-boson systems. This is achieved through application of the representation theory for polynomial deformations of the $su(2)$ Lie algebra. We demonstrate that the family of Hamiltonians includes, as special cases, known physical models which are the two-site Bose-Hubbard model, the Lipkin-Meshkov-Glick model, the molecular asymmetric rigid rotor, the Tavis-Cummings model, and a two-mode generalisation of the Tavis-Cummings model.Comment: LaTex 15 pages. To appear in Nonlinearit

An algebraic approach to the Tavis-Cummings problem

An algebraic method is introduced for an analytical solution of the eigenvalue problem of the Tavis-Cummings (TC) Hamiltonian, based on polynomially deformed su(2), i.e. su_n(2), algebras. In this method the eigenvalue problem is solved in terms of a specific perturbation theory, developed here up to third order. Generalization to the N-atom case of the Rabi frequency and dressed states is also provided. A remarkable enhancement of spontaneous emission of N atoms in a resonator is found to result from collective effects.Comment: 13 pages, 7 figure