Организация работ по защите от коррозии линейной части магистрального газопровода с применением статистических методов

Объектом исследования является магистральный газопровод с диаметром 1220 мм и толщиной стенки 9,5 мм. Цель работы - выбор оптимальных параметров работы станции катодной защиты с применением статистических методов для обеспечения надежной эксплуатации газопровода. В данной исследовательской работе рассмотрены методы оптимизации параметров катодной станции. В результате исследования был применен статистический метод контрольных карт Шухарта и расчет электрохимических параметров трубопровода с подбором оборудования.The subject of the research is a gas main line with a diameter of 1220 mm and a wall thickness of 9.5 mm. The objective of the work is to choose the optimal parameters of the cathode protection station using statistical methods to ensure the reliable operation of the gas pipeline. In this research work methods optimization parameters of cathode station are considered. The research applied the statistical method of Shewhart control chart and the calculation of electrochemical parameters of the pipeline with the selection of equipment

Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4 proteins. Recent studies show that AT/RTs comprise three molecular subgroups, namely AT/RT-TYR, AT/RT-MYC and AT/RT-SHH. The subgroups show distinct expression patterns of genes involved in ciliogenesis, however, little is known about the functional roles of primary cilia in the biology of AT/RT. Here, we show that primary cilia are present across all AT/RT subgroups with specific enrichment in AT/RT-TYR patient samples. Furthermore, we demonstrate that primary ciliogenesis contributes to AT/RT biology in vitro and in vivo. Specifically, we observed a significant decrease in proliferation and clonogenicity following disruption of primary ciliogenesis in AT/RT cell line models. Additionally, apoptosis was significantly increased via the induction of STAT1 and DR5 signaling, as detected by proteogenomic profiling. In a Drosophila model of SMARCB1 deficiency, concomitant knockdown of several cilia-associated genes resulted in a substantial shift of the lethal phenotype with more than 20% of flies reaching adulthood. We also found significantly extended survival in an orthotopic xenograft mouse model of AT/RT upon disruption of primary ciliogenesis. Taken together, our findings indicate that primary ciliogenesis or its downstream signaling contributes to the aggressiveness of AT/RT and, therefore, may constitute a novel therapeutic target

“It’s not something I chose you know”: making sense of pedophiles’ sexual interest in children and the impact on their psychosexual identity

Sexual interest in children is one of the most strongly predictive of the known risk factors for sexual reconviction. It is an important aspect of risk assessment to identify the presence of such interest, and an important task for treatment providers to address such a sexual interest where it is present. It has been argued that understanding pedophiles’ deviant sexual interest in children can enhance risk assessment, management, and treatment planning. This research study aims to explore the phenomenology of deviant sexual interest in children, the impact it has on pedophilic offenders’ identities, and their views on the treatability of that interest. The study used semistructured interviews and repertory grids to make sense of participants’ experiences. The results revealed three superordinate themes: “‘living’ with a deviant sexual interest,” “relational sexual self,” and “possible and feared sexual self.” The analysis unpacks these themes and repertory grid analysis is used to explore a subset of participants’ identities in more detail. The results reveal that there needs to be an acceptance from both client and therapist that their sexual interest in children may never go away. Through this acceptance, clients could work on enhancing sexual self-regulation, recognizing their triggers, and so managing their sexual thoughts, feelings, and behavior. Implications for treatment are also discussed