56 research outputs found
Integrating environmental, entomological, animal, and human data to model the Leishmania infantum transmission risk in a newly endemic area in Northern Italy
Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6–9 Years of age : a cross-sectional analysis within the C8 health project
Background: Exposure to some perfluoroalkyl substances (PFAS), such as perfluorohexane sulfonate
(PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid
(PFNA), may alter levels of sex hormones and insulin-like growth factor-1 (IGF-1) in animals. Human
studies on this topic are scarce and none have been conducted in young children.
Objectives: To investigate the relationship between levels of PFAS and estradiol, total testosterone and
IGF-1 in 2,292 children (aged 6-9 years) from the C8 Health Project living near a chemical plant in the
Mid-Ohio Valley (USA) with local contamination from PFOA.
Methods: Serum samples were collected in 2005-2006 and analyzed for PFAS, sex hormones and
IGF-1. Results from regression models were expressed as the adjusted percentage difference (95% CI)
per sex-specific interquartile range (IQR) increment of each PFAS serum concentration. Analyses by
PFAS quartiles were also conducted.
Results: Median concentrations of PFHxS, PFOA, PFOS, and PFNA were 8, 35, 22, and 1.7 ng/mL in
boys and 7, 30, 21, and 1.7 ng/mL in girls. In boys, PFOA concentrations were significantly associated
with testosterone levels (-4.9% [-8.7, -0.8%]); PFOS with estradiol (-4.0% [-7.7, -0.1%]), testosterone
(-5.8% [-9.4, -2.0%]), and IGF-1 (-5.9% [-8.3, -3.3%]); and PFNA with IGF-1 (-3.5% [-6.0, -1.0%]). In
girls, significant associations were found between PFOS and testosterone (-6.6% [-10.1, -2.8%]) and
IGF-1 (-5.6% [-8.2, -2.9%]); and PFNA and IGF-1 (-3.8% [-6.4, -1.2%]). In both sexes, the magnitudes
of the associations decreased monotonically across quartiles for testosterone and PFOS, and for IGF-1
and both PFOS and PFNA.
Conclusions: To our knowledge, this is the first study suggesting that PFAS are associated with lowe
Establishing climatic constraints shaping the distribution of alien plant species along the elevation gradient in the Alps
Sviluppo di una piattaforma di indagine genetica applicabile alla scelta della terapia farmacologica e studio delle varianti alleliche del citocromo P450 nella popolazione sarda
Sviluppo di una piattaforma di indagine genetica: Scelta della terapia psicofarmacologica e studio delle varianti del Citocromo P450 nei sardi
Papilio hospiton isolate ND1PHS02 NADH dehydrogenase subunit 1 (ND1) gene, partial cds; mitochondrial
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