11 research outputs found
Supplementary Material for: Accumulation of carbamylation-derived products in aneurysmal aorta
Introduction: Carbamylation is a nonenzymatic post-translational modification of proteins characterized by the binding of isocyanic acid to amino groups of proteins, which leads to the alteration of their properties. An increase of serum carbamylation-derived products, including homocitrulline (HCit), has been shown to be associated with the development of cardiovascular diseases.
Methods: HCit was quantified by LC-MS/MS within extracts of aneurysmal and control human aortas. A mouse model of aortic aneurysm (ApoE-/- mice perfused with angiotensin II and fed with sodium cyanate) was used to evaluate the role of carbamylation in aneurysm development.
Results: HCit quantification showed a greater heterogeneity of values in aneurysmal aortas in comparison with control ones. At the maximum diameter of dilation, HCit values were significantly higher (+94%, p<0.05) compared with less dilated areas. No differences was observed according to aneurysm size or when comparing ruptured and unruptured aneurysms. No significant effect of carbamylation on aneurysm development was observed using the animal model.
Conclusions: These results evidenced the accumulation of HCit within aneurysmal aortas but do not allow to conclude about the exact participation of protein carbamylation in the development of human abdominal aortic aneurysms
Receptor for advanced glycation end products : a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.
International audienc
High Throughput Identification and Quantification of Anabolic Steroid Esters by Atmospheric Solids Analysis Probe Mass Spectrometry for Efficient Screening of Drug Preparations
Religiosity and Depressive Episodes among African Migrant HIV-positive: The Mediation of Subjective Health
Recueil d'Airs sérieux et à boire de différents auteurs ; pour l'année 1713
Présentation musicale : [Partition